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LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process.

Qin Y, Zhu W, Xu W, Zhang B, Shi S, Ji S, Liu J, Long J, Liu C, Liu L, Xu J, Yu X.

Cancer Lett. 2014 Jun 1;347(2):225-32. doi: 10.1016/j.canlet.2014.02.013.


Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.

Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, Nakao M.

Cancer Res. 2015 Apr 1;75(7):1445-56. doi: 10.1158/0008-5472.CAN-14-1560.


Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology.

Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, Kirfel J.

Carcinogenesis. 2010 Mar;31(3):512-20. doi: 10.1093/carcin/bgp324.


Effects of the silencing of hypoxia-inducible Factor-1 alpha on metastasis of pancreatic cancer.

Wei H, Li F, Fu P, Liu X.

Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):436-46.


Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties.

Wang J, Lu F, Ren Q, Sun H, Xu Z, Lan R, Liu Y, Ward D, Quan J, Ye T, Zhang H.

Cancer Res. 2011 Dec 1;71(23):7238-49. doi: 10.1158/0008-5472.CAN-11-0896.


Hypoxia-inducible factor-1 up-regulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions.

Fan P, Zhang JJ, Wang B, Wu HQ, Zhou SX, Wang CY, Zhang JH, Tian Y, Wu HS.

Pancreatology. 2012 Mar-Apr;12(2):170-8. doi: 10.1016/j.pan.2012.02.015.


LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.

Ding J, Zhang ZM, Xia Y, Liao GQ, Pan Y, Liu S, Zhang Y, Yan ZS.

Br J Cancer. 2013 Aug 20;109(4):994-1003. doi: 10.1038/bjc.2013.364.


High expression of lysine-specific demethylase 1 correlates with poor prognosis of patients with esophageal squamous cell carcinoma.

Yu Y, Wang B, Zhang K, Lei Z, Guo Y, Xiao H, Wang J, Fan L, Lan C, Wei Y, Ma Q, Lin L, Mao C, Yang X, Chen X, Li Y, Bai Y, Chen D.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):192-8. doi: 10.1016/j.bbrc.2013.05.123.


Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis.

Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X.

Mol Cancer. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187.


Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene.

Zhu Q, Liu C, Ge Z, Fang X, Zhang X, Strååt K, Björkholm M, Xu D.

PLoS One. 2008 Jan 16;3(1):e1446. doi: 10.1371/journal.pone.0001446.


Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.

Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura Ki, Hosokawa M, Asaka M.

Cancer Res. 2001 Sep 1;61(17):6548-54.


Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R.

Nature. 2010 Apr 1;464(7289):792-6. doi: 10.1038/nature08839.


Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer.

Lv T, Yuan D, Miao X, Lv Y, Zhan P, Shen X, Song Y.

PLoS One. 2012;7(4):e35065. doi: 10.1371/journal.pone.0035065.


Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.

Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, Versteeg R, Ora I, Pajtler K, Klein-Hitpass L, Kuhfittig-Kulle S, Metzger E, Schüle R, Eggert A, Buettner R, Kirfel J.

Cancer Res. 2009 Mar 1;69(5):2065-71. doi: 10.1158/0008-5472.CAN-08-1735.


Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].

Huang Z, Li S, Song W, Li X, Li Q, Zhang Z, Han Y, Zhang X, Miao S, Du R, Wang L.

PLoS One. 2013 Jul 26;8(7):e70077. doi: 10.1371/journal.pone.0070077. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/d090733e-1f34-43c5-a06a-255456946303.


The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells.

Lan W, Zhang D, Jiang J.

Med Hypotheses. 2013 Nov;81(5):823-5. doi: 10.1016/j.mehy.2013.09.005.


Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L: -ascorbate on pancreatic tumors in athymic mice.

Chen C, Sun J, Liu G, Chen J.

Pathol Oncol Res. 2009 Mar;15(1):109-14. doi: 10.1007/s12253-008-9063-7.

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