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Items: 1 to 20 of 237

1.

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP.

Immunity. 2014 Mar 20;40(3):329-41. doi: 10.1016/j.immuni.2014.01.010. Epub 2014 Feb 20. Review.

2.

STING is a direct innate immune sensor of cyclic di-GMP.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE.

Nature. 2011 Sep 25;478(7370):515-8. doi: 10.1038/nature10429.

3.

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.

Immunity. 2014 Dec 18;41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28.

4.

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.

Ishikawa H, Ma Z, Barber GN.

Nature. 2009 Oct 8;461(7265):788-92. doi: 10.1038/nature08476. Epub 2009 Sep 23.

5.

Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.

Abe T, Barber GN.

J Virol. 2014 May;88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5.

6.

The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.

Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB, Wang YY.

Cell Host Microbe. 2014 Oct 8;16(4):450-61. doi: 10.1016/j.chom.2014.09.006.

7.

The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production.

Tocker AM, Durocher E, Jacob KD, Trieschman KE, Talento SM, Rechnitzer AA, Roberts DM, Davis BK.

J Immunol. 2017 Oct 15;199(8):2896-2909. doi: 10.4049/jimmunol.1601370. Epub 2017 Sep 1.

8.

Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING.

Chin KH, Tu ZL, Su YC, Yu YJ, Chen HC, Lo YC, Chen CP, Barber GN, Chuah ML, Liang ZX, Chou SH.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):352-66. doi: 10.1107/S0907444912047269. Epub 2013 Feb 16. Erratum in: Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1191.

PMID:
23519410
9.

Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING.

Panchanathan R, Liu H, Xin D, Choubey D.

Innate Immun. 2014 Oct;20(7):751-9. doi: 10.1177/1753425913507097. Epub 2013 Oct 16.

PMID:
24131791
10.

Binding of bacterial secondary messenger molecule c di-GMP is a STING operation.

Shaw N, Ouyang S, Liu ZJ.

Protein Cell. 2013 Feb;4(2):117-29. doi: 10.1007/s13238-012-2071-0. Epub 2012 Dec 20. Review.

11.

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.

12.

NLRC3 puts the brakes on STING.

Mangan MS, Latz E.

Immunity. 2014 Mar 20;40(3):305-6. doi: 10.1016/j.immuni.2014.02.007.

13.

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.

14.

RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection.

Liu Y, Goulet ML, Sze A, Hadj SB, Belgnaoui SM, Lababidi RR, Zheng C, Fritz JH, Olagnier D, Lin R.

J Virol. 2016 Sep 29;90(20):9406-19. doi: 10.1128/JVI.00748-16. Print 2016 Oct 15.

15.

Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1.

Deschamps T, Kalamvoki M.

J Virol. 2017 Jul 27;91(16). pii: e00535-17. doi: 10.1128/JVI.00535-17. Print 2017 Aug 15.

16.

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41.

Su C, Zheng C.

J Virol. 2017 Feb 28;91(6). pii: e02414-16. doi: 10.1128/JVI.02414-16. Print 2017 Mar 15.

17.

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.

Cell Host Microbe. 2016 Apr 13;19(4):515-528. doi: 10.1016/j.chom.2016.03.001.

18.

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.

19.

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.

Luo WW, Li S, Li C, Lian H, Yang Q, Zhong B, Shu HB.

Nat Immunol. 2016 Sep;17(9):1057-66. doi: 10.1038/ni.3510. Epub 2016 Jul 18.

PMID:
27428826
20.

A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin.

Royer DJ, Carr DJ.

Mucosal Immunol. 2016 Jul;9(4):1065-75. doi: 10.1038/mi.2015.124. Epub 2015 Dec 2.

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