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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP.

Immunity. 2014 Mar 20;40(3):329-41. doi: 10.1016/j.immuni.2014.01.010. Epub 2014 Feb 20. Review.


STING is a direct innate immune sensor of cyclic di-GMP.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE.

Nature. 2011 Sep 25;478(7370):515-8. doi: 10.1038/nature10429.


The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.

Immunity. 2014 Dec 18;41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28.


STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.

Ishikawa H, Ma Z, Barber GN.

Nature. 2009 Oct 8;461(7265):788-92. doi: 10.1038/nature08476. Epub 2009 Sep 23.


Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.

Abe T, Barber GN.

J Virol. 2014 May;88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5.


The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.

Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB, Wang YY.

Cell Host Microbe. 2014 Oct 8;16(4):450-61. doi: 10.1016/j.chom.2014.09.006.


Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING.

Chin KH, Tu ZL, Su YC, Yu YJ, Chen HC, Lo YC, Chen CP, Barber GN, Chuah ML, Liang ZX, Chou SH.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):352-66. doi: 10.1107/S0907444912047269. Epub 2013 Feb 16. Erratum in: Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1191.


Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING.

Panchanathan R, Liu H, Xin D, Choubey D.

Innate Immun. 2014 Oct;20(7):751-9. doi: 10.1177/1753425913507097. Epub 2013 Oct 16.


Binding of bacterial secondary messenger molecule c di-GMP is a STING operation.

Shaw N, Ouyang S, Liu ZJ.

Protein Cell. 2013 Feb;4(2):117-29. doi: 10.1007/s13238-012-2071-0. Epub 2012 Dec 20. Review.


The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.


NLRC3 puts the brakes on STING.

Mangan MS, Latz E.

Immunity. 2014 Mar 20;40(3):305-6. doi: 10.1016/j.immuni.2014.02.007.


The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.


NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.

Cell Host Microbe. 2016 Apr 13;19(4):515-28. doi: 10.1016/j.chom.2016.03.001.


Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.


Mechanisms and pathways of innate immune activation and regulation in health and cancer.

Cui J, Chen Y, Wang HY, Wang RF.

Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640. Review.


Crystallization studies of the murine c-di-GMP sensor protein STING.

Su YC, Tu ZL, Yang CY, Chin KH, Chuah ML, Liang ZX, Chou SH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):906-10. doi: 10.1107/S1744309112024372. Epub 2012 Jul 31.


Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding.

Ouyang S, Song X, Wang Y, Ru H, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G, Liu ZJ.

Immunity. 2012 Jun 29;36(6):1073-86. doi: 10.1016/j.immuni.2012.03.019. Epub 2012 May 10.


Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

Yi G, Brendel VP, Shu C, Li P, Palanathan S, Cheng Kao C.

PLoS One. 2013 Oct 21;8(10):e77846. doi: 10.1371/journal.pone.0077846. eCollection 2013 Oct 21.


S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ES, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-22. doi: 10.1038/ni.3433. Epub 2016 Apr 4.


Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.

Sun L, Xing Y, Chen X, Zheng Y, Yang Y, Nichols DB, Clementz MA, Banach BS, Li K, Baker SC, Chen Z.

PLoS One. 2012;7(2):e30802. doi: 10.1371/journal.pone.0030802. Epub 2012 Feb 1.

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