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Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.

Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ.

Biochemistry. 2014 Mar 18;53(10):1697-713. doi: 10.1021/bi4016082. Epub 2014 Mar 7.


Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains.

Ananthanarayanan B, Stahelin RV, Digman MA, Cho W.

J Biol Chem. 2003 Nov 21;278(47):46886-94. Epub 2003 Sep 3.


Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta.

Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Rafter JD, Melowic HR, Cho W.

J Biol Chem. 2004 Jul 9;279(28):29501-12. Epub 2004 Apr 22.


The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

Stahelin RV, Wang J, Blatner NR, Rafter JD, Murray D, Cho W.

J Biol Chem. 2005 Oct 28;280(43):36452-63. Epub 2005 Aug 3.


Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.

Corbin JA, Evans JH, Landgraf KE, Falke JJ.

Biochemistry. 2007 Apr 10;46(14):4322-36. Epub 2007 Mar 17.


Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.

Landgraf KE, Malmberg NJ, Falke JJ.

Biochemistry. 2008 Aug 12;47(32):8301-16. doi: 10.1021/bi800711t. Epub 2008 Jul 9.


Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.

Scott AM, Antal CE, Newton AC.

J Biol Chem. 2013 Jun 7;288(23):16905-15. doi: 10.1074/jbc.M113.467456. Epub 2013 Apr 15.


Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.

Li J, Ziemba BP, Falke JJ, Voth GA.

J Am Chem Soc. 2014 Aug 20;136(33):11757-66. doi: 10.1021/ja505369r. Epub 2014 Aug 11.


Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα.

McCary CA, Yoon Y, Panagabko C, Cho W, Atkinson J, Cook-Mills JM.

Biochem J. 2012 Jan 1;441(1):189-98. doi: 10.1042/BJ20111318.


Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon.

Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Melowic HR, Rafter JD, Cho W.

J Biol Chem. 2005 May 20;280(20):19784-93. Epub 2005 Mar 15.


PKCalpha: a versatile key for decoding the cellular calcium toolkit.

Reither G, Schaefer M, Lipp P.

J Cell Biol. 2006 Aug 14;174(4):521-33. Epub 2006 Aug 7.


Molecular mechanisms of PKCalpha localization and activation by arachidonic acid. The C2 domain also plays a role.

López-Nicolás R, López-Andreo MJ, Marín-Vicente C, Gómez-Fernández JC, Corbalán-García S.

J Mol Biol. 2006 Apr 7;357(4):1105-20. Epub 2006 Jan 25.


A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production.

Dries DR, Gallegos LL, Newton AC.

J Biol Chem. 2007 Jan 12;282(2):826-30. Epub 2006 Oct 27.


Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.

Lai CL, Landgraf KE, Voth GA, Falke JJ.

J Mol Biol. 2010 Sep 17;402(2):301-10. doi: 10.1016/j.jmb.2010.07.037. Epub 2010 Jul 24.


Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.

Evans JH, Murray D, Leslie CC, Falke JJ.

Mol Biol Cell. 2006 Jan;17(1):56-66. Epub 2005 Oct 19.

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