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Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids.

Chaves JA, Sanchez-López C, Gomes MP, Sisnande T, Macedo B, de Oliveira VE, Braga CA, Rangel LP, Silva JL, Quintanar L, Cordeiro Y.

J Biol Inorg Chem. 2014 Aug;19(6):839-51. doi: 10.1007/s00775-014-1115-8. Epub 2014 Feb 21.


Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.

Jones CE, Abdelraheim SR, Brown DR, Viles JH.

J Biol Chem. 2004 Jul 30;279(31):32018-27. Epub 2004 May 15.


Deconvoluting the Cu2+ binding modes of full-length prion protein.

Klewpatinond M, Davies P, Bowen S, Brown DR, Viles JH.

J Biol Chem. 2008 Jan 25;283(4):1870-81. Epub 2007 Nov 26.


The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.

Giachin G, Mai PT, Tran TH, Salzano G, Benetti F, Migliorati V, Arcovito A, Della Longa S, Mancini G, D'Angelo P, Legname G.

Sci Rep. 2015 Oct 20;5:15253. doi: 10.1038/srep15253.


Both Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH.

Shearer J, Soh P, Lentz S.

J Inorg Biochem. 2008 Dec;102(12):2103-13. doi: 10.1016/j.jinorgbio.2008.07.016. Epub 2008 Aug 6.


Cross-talk between the octarepeat domain and the fifth binding site of prion protein driven by the interaction of copper(II) with the N-terminus.

Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E.

Chemistry. 2015 Mar 2;21(10):4071-84. doi: 10.1002/chem.201405502. Epub 2015 Feb 3.


Copper binding to the prion protein: structural implications of four identical cooperative binding sites.

Viles JH, Cohen FE, Prusiner SB, Goodin DB, Wright PE, Dyson HJ.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2042-7.


Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

Bocharova OV, Breydo L, Salnikov VV, Baskakov IV.

Biochemistry. 2005 May 10;44(18):6776-87.


Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.

Redecke L, Meyer-Klaucke W, Koker M, Clos J, Georgieva D, Genov N, Echner H, Kalbacher H, Perbandt M, Bredehorst R, Voelter W, Betzel C.

J Biol Chem. 2005 Apr 8;280(14):13987-92. Epub 2005 Jan 30.


Copper and the structural biology of the prion protein.

Viles JH, Klewpatinond M, Nadal RC.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1288-92. doi: 10.1042/BST0361288. Review.


Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein.

Remelli M, Valensin D, Toso L, Gralka E, Guerrini R, Marzola E, Kozłowski H.

Metallomics. 2012 Aug;4(8):794-806. doi: 10.1039/c2mt20060k. Epub 2012 Jul 13.


Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein.

Younan ND, Klewpatinond M, Davies P, Ruban AV, Brown DR, Viles JH.

J Mol Biol. 2011 Jul 15;410(3):369-82. doi: 10.1016/j.jmb.2011.05.013. Epub 2011 May 17.


The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions.

Leliveld SR, Dame RT, Wuite GJ, Stitz L, Korth C.

J Biol Chem. 2006 Feb 10;281(6):3268-75. Epub 2005 Dec 13.


New insights into metal interactions with the prion protein: EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion protein.

McDonald A, Pushie MJ, Millhauser GL, George GN.

J Phys Chem B. 2013 Nov 7;117(44):13822-41. doi: 10.1021/jp408239h. Epub 2013 Oct 30.


Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry.

Whittal RM, Ball HL, Cohen FE, Burlingame AL, Prusiner SB, Baldwin MA.

Protein Sci. 2000 Feb;9(2):332-43.


Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.

Thakur AK, Srivastava AK, Srinivas V, Chary KV, Rao CM.

J Biol Chem. 2011 Nov 4;286(44):38533-45. doi: 10.1074/jbc.M111.265645. Epub 2011 Sep 7.


Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein.

Valensin D, Padula EM, Hecel A, Luczkowski M, Kozlowski H.

J Inorg Biochem. 2016 Feb;155:26-35. doi: 10.1016/j.jinorgbio.2015.11.015. Epub 2015 Nov 11.


Copper coordination in the full-length, recombinant prion protein.

Burns CS, Aronoff-Spencer E, Legname G, Prusiner SB, Antholine WE, Gerfen GJ, Peisach J, Millhauser GL.

Biochemistry. 2003 Jun 10;42(22):6794-803.

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