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N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury.

Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X.

J Neurosci. 2014 Feb 19;34(8):2967-78. doi: 10.1523/JNEUROSCI.1948-13.2014.


Poloxamer 188 Attenuates Cerebral Hypoxia/Ischemia Injury in Parallel with Preventing Mitochondrial Membrane Permeabilization and Autophagic Activation.

Luo C, Li Q, Gao Y, Shen X, Ma L, Wu Q, Wang Z, Zhang M, Zhao Z, Chen X, Tao L.

J Mol Neurosci. 2015 Aug;56(4):988-98. doi: 10.1007/s12031-015-0568-8. Epub 2015 May 13.


Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury.

Wang M, Li YJ, Ding Y, Zhang HN, Sun T, Zhang K, Yang L, Guo YY, Liu SB, Zhao MG, Wu YM.

Mol Neurobiol. 2016 Mar;53(2):932-43. doi: 10.1007/s12035-014-9062-5. Epub 2015 Jan 7.


Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury.

Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS, Friedlander RM.

Stroke. 2009 May;40(5):1877-85. doi: 10.1161/STROKEAHA.108.540765. Epub 2009 Mar 19.


Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury.

Zhang WH, Wang H, Wang X, Narayanan MV, Stavrovskaya IG, Kristal BS, Friedlander RM.

Stroke. 2008 Feb;39(2):455-62. doi: 10.1161/STROKEAHA.107.496810. Epub 2008 Jan 3.


N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide.

Jiang J, Yu S, Jiang Z, Liang C, Yu W, Li J, Du X, Wang H, Gao X, Wang X.

Oxid Med Cell Longev. 2014;2014:310504. doi: 10.1155/2014/310504. Epub 2014 Jun 12.


Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways.

Sohn EJ, Shin MJ, Eum WS, Kim DW, Yong JI, Ryu EJ, Park JH, Cho SB, Cha HJ, Kim SJ, Yeo HJ, Yeo EJ, Choi YJ, Im SK, Kweon HY, Kim DS, Yu YH, Cho SW, Park M, Park J, Cho YJ, Choi SY.

Int J Mol Med. 2016 Jul;38(1):225-35. doi: 10.3892/ijmm.2016.2596. Epub 2016 May 19.


Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.

Qin AP, Liu CF, Qin YY, Hong LZ, Xu M, Yang L, Liu J, Qin ZH, Zhang HL.

Autophagy. 2010 Aug;6(6):738-53. Epub 2010 Aug 3.


Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism.

Adembri C, Venturi L, Tani A, Chiarugi A, Gramigni E, Cozzi A, Pancani T, De Gaudio RA, Pellegrini-Giampietro DE.

Anesthesiology. 2006 Jan;104(1):80-9.


Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.

Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY.

Autophagy. 2012 Jan;8(1):77-87. doi: 10.4161/auto.8.1.18274. Epub 2012 Jan 1.


A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.

Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL.

Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19.


Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice.

Ding K, Xu J, Wang H, Zhang L, Wu Y, Li T.

Neurochem Int. 2015 Dec;91:46-54. doi: 10.1016/j.neuint.2015.10.008. Epub 2015 Oct 23.


Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways.

Meng X, Wang M, Wang X, Sun G, Ye J, Xu H, Sun X.

Free Radic Res. 2014 Jul;48(7):823-38. doi: 10.3109/10715762.2014.911853. Epub 2014 May 7.


Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway.

Gao Y, Signore AP, Yin W, Cao G, Yin XM, Sun F, Luo Y, Graham SH, Chen J.

J Cereb Blood Flow Metab. 2005 Jun;25(6):694-712.


Dipyrone inhibits neuronal cell death and diminishes hypoxic/ischemic brain injury.

Zhang Y, Wang X, Baranov SV, Zhu S, Huang Z, Fellows-Mayle W, Jiang J, Day AL, Kristal BS, Friedlander RM.

Neurosurgery. 2011 Oct;69(4):942-56. doi: 10.1227/NEU.0b013e318222afb2.


Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia.

Mehta SL, Kumari S, Mendelev N, Li PA.

BMC Neurosci. 2012 Jul 9;13:79. doi: 10.1186/1471-2202-13-79.


Protection against Experimental Stroke by Ganglioside GM1 Is Associated with the Inhibition of Autophagy.

Li L, Tian J, Long MK, Chen Y, Lu J, Zhou C, Wang T.

PLoS One. 2016 Jan 11;11(1):e0144219. doi: 10.1371/journal.pone.0144219. eCollection 2016.


An active component of Achyranthes bidentata polypeptides provides neuroprotection through inhibition of mitochondrial-dependent apoptotic pathway in cultured neurons and in animal models of cerebral ischemia.

Yu S, Wang C, Cheng Q, Xu H, Zhang S, Li L, Zhang Q, Gu X, Ding F.

PLoS One. 2014 Oct 15;9(10):e109923. doi: 10.1371/journal.pone.0109923. eCollection 2014.


Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.

Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF.

FASEB J. 2004 May;18(7):869-71. Epub 2004 Mar 19.


N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.

Iuvone PM, Boatright JH, Tosini G, Ye K.

Adv Exp Med Biol. 2014;801:765-71. doi: 10.1007/978-1-4614-3209-8_96.

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