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Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling.

Xiao TT, Wang YY, Zhang Y, Bai CH, Shen XC.

PLoS One. 2014 Feb 13;9(2):e88856. doi: 10.1371/journal.pone.0088856. eCollection 2014.


Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes.

Xiao T, Zhang Y, Wang Y, Xu Y, Yu Z, Shen X.

Food Chem Toxicol. 2013 Mar;53:364-70. doi: 10.1016/j.fct.2012.12.022. Epub 2012 Dec 22.


Oxymatrine protects against sepsis-induced myocardial injury via inhibition of the TNF-α/p38-MAPK/caspase-3 signaling pathway.

Zhang M, Wang X, Bai B, Zhang R, Li Y, Wang Y.

Mol Med Rep. 2016 Jul;14(1):551-9. doi: 10.3892/mmr.2016.5250. Epub 2016 May 11.


Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.

Han X, Liu C, Zhang K, Guo M, Shen Z, Liu Y, Zuo Z, Cao M, Li Y.

Toxicol Lett. 2018 Mar 15;285:60-73. doi: 10.1016/j.toxlet.2017.12.022. Epub 2017 Dec 28.


Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro.

Ding ZJ, Chen X, Tang XX, Wang X, Song YL, Chen XD, Mi WJ, Wang J, Lin Y, Chen FQ, Qiu JH.

PLoS One. 2015 Apr 15;10(4):e0123130. doi: 10.1371/journal.pone.0123130. eCollection 2015.


Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J.

J Neurosci. 2007 Aug 29;27(35):9278-93.


Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway.

Wang W, Peng Y, Wang Y, Zhao X, Yuan Z.

Clin Exp Pharmacol Physiol. 2009 Sep;36(9):899-903. doi: 10.1111/j.1440-1681.2009.05167.x. Epub 2009 Mar 2.


Phosphatidylinositol Induces Caspase-Independent Apoptosis of Malignant Pleural Mesothelioma Cells by Accumulating AIF in the Nucleus.

Kanemura S, Tsuchiya A, Kanno T, Nakano T, Nishizaki T.

Cell Physiol Biochem. 2015;36(3):1037-48. doi: 10.1159/000430277. Epub 2015 Jun 18.


Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats.

Ozaki T, Ishiguro S, Hirano S, Baba A, Yamashita T, Tomita H, Nakazawa M.

PLoS One. 2013 Aug 9;8(8):e71650. doi: 10.1371/journal.pone.0071650. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/7a8aaf1d-e968-4b39-abb0-867d6078b2af.


Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study.

Fu L, Xu Y, Tu L, Huang H, Zhang Y, Chen Y, Tao L, Shen X.

BMC Complement Altern Med. 2016 Jul 26;16:241. doi: 10.1186/s12906-016-1231-9.


Protective paracrine effect of mesenchymal stem cells on cardiomyocytes.

Xiang MX, He AN, Wang JA, Gui C.

J Zhejiang Univ Sci B. 2009 Aug;10(8):619-24. doi: 10.1631/jzus.B0920153.


Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells.

Miyake K, Bekisz J, Zhao T, Clark CR, Zoon KC.

Biochim Biophys Acta. 2012 Aug;1823(8):1378-88. doi: 10.1016/j.bbamcr.2012.05.031. Epub 2012 Jun 7.


Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro.

Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1063-9. Epub 2003 Nov 13.


Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage.

Chae SU, Ha KC, Piao CS, Chae SW, Chae HJ.

Arch Pharm Res. 2007 Oct;30(10):1225-35.


Transglutaminase 2 promotes both caspase-dependent and caspase-independent apoptotic cell death via the calpain/Bax protein signaling pathway.

Yoo JO, Lim YC, Kim YM, Ha KS.

J Biol Chem. 2012 Apr 27;287(18):14377-88. doi: 10.1074/jbc.M111.326074. Epub 2012 Mar 14.


Apoptosis-inducing factor and calpain upregulation in glutamate-induced injury of rat spiral ganglion neurons.

Ding ZJ, Chen X, Tang XX, Wang X, Song YL, Chen XD, Wang J, Wang RF, Mi WJ, Chen FQ, Qiu JH.

Mol Med Rep. 2015 Aug;12(2):1685-92. doi: 10.3892/mmr.2015.3626. Epub 2015 Apr 16.


Myofibrillogenesis regulator-1 attenuated hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes.

Tao TQ, Wang XR, Liu M, Xu FF, Liu XH.

Apoptosis. 2015 Mar;20(3):285-97. doi: 10.1007/s10495-014-1081-1.


Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.

De Silva DS, Wilson RM, Hutchinson C, Ip PC, Garcia AG, Lancel S, Ito M, Pimentel DR, Sam F.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1983-93. doi: 10.1152/ajpheart.00002.2009. Epub 2009 Apr 24.

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