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Items: 1 to 20 of 112

1.
3.

Gremlin is a downstream profibrotic mediator of transforming growth factor-beta in cultured renal cells.

Rodrigues-Diez R, Lavoz C, Carvajal G, Rayego-Mateos S, Rodrigues Diez RR, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M.

Nephron Exp Nephrol. 2012;122(1-2):62-74. doi: 10.1159/000346575. Epub 2013 Mar 14.

PMID:
23548835
4.

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma.

Lakos G, Takagawa S, Chen SJ, Ferreira AM, Han G, Masuda K, Wang XJ, DiPietro LA, Varga J.

Am J Pathol. 2004 Jul;165(1):203-17.

5.

TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.

Ma B, Kang Q, Qin L, Cui L, Pei C.

Biochem Biophys Res Commun. 2014 May 16;447(4):689-95. doi: 10.1016/j.bbrc.2014.04.068. Epub 2014 Apr 19.

PMID:
24755068
6.

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M.

J Biol Chem. 2007 Apr 6;282(14):10405-13. Epub 2007 Feb 15.

7.

EphrinB2 Regulates Cardiac Fibrosis Through Modulating the Interaction of Stat3 and TGF-β/Smad3 Signaling.

Su SA, Yang D, Wu Y, Xie Y, Zhu W, Cai Z, Shen J, Fu Z, Wang Y, Jia L, Wang Y, Wang JA, Xiang M.

Circ Res. 2017 Sep 1;121(6):617-627. doi: 10.1161/CIRCRESAHA.117.311045. Epub 2017 Jul 25.

PMID:
28743805
8.

Prevention of early postnatal hyperalimentation protects against activation of transforming growth factor-β/bone morphogenetic protein and interleukin-6 signaling in rat lungs after intrauterine growth restriction.

Alcázar MA, Dinger K, Rother E, Östreicher I, Vohlen C, Plank C, Dötsch J.

J Nutr. 2014 Dec;144(12):1943-51. doi: 10.3945/jn.114.197657. Epub 2014 Oct 1.

9.
10.

JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells.

Liu RY, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang HT.

Int J Oncol. 2014 May;44(5):1643-51. doi: 10.3892/ijo.2014.2310. Epub 2014 Feb 21.

PMID:
24573038
11.

Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation.

Liu Y, Liu H, Meyer C, Li J, Nadalin S, Königsrainer A, Weng H, Dooley S, ten Dijke P.

J Biol Chem. 2013 Oct 18;288(42):30708-19. doi: 10.1074/jbc.M113.478685. Epub 2013 Sep 4.

12.

Gremlin aggravates hyperglycemia-induced podocyte injury by a TGFβ/smad dependent signaling pathway.

Li G, Li Y, Liu S, Shi Y, Chi Y, Liu G, Shan T.

J Cell Biochem. 2013 Sep;114(9):2101-13. doi: 10.1002/jcb.24559.

PMID:
23553804
13.

Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):321-9. Epub 2007 Nov 1.

14.

Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition.

Lee JW, Zoumalan RA, Valenzuela CD, Nguyen PD, Tutela JP, Roman BR, Warren SM, Saadeh PB.

Otolaryngol Head Neck Surg. 2010 Oct;143(4):525-30. doi: 10.1016/j.otohns.2010.06.912.

PMID:
20869563
15.

CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity.

Luzina IG, Tsymbalyuk N, Choi J, Hasday JD, Atamas SP.

J Cell Physiol. 2006 Jan;206(1):221-8.

PMID:
16021625
16.

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.

Tomcik M, Palumbo-Zerr K, Zerr P, Sumova B, Avouac J, Dees C, Distler A, Becvar R, Distler O, Schett G, Senolt L, Distler JH.

Ann Rheum Dis. 2016 Mar;75(3):609-16. doi: 10.1136/annrheumdis-2014-206234. Epub 2015 Jan 20.

PMID:
25603829
17.

MicroRNA-27b targets gremlin 1 to modulate fibrotic responses in pulmonary cells.

Graham JR, Williams CM, Yang Z.

J Cell Biochem. 2014 Sep;115(9):1539-48. doi: 10.1002/jcb.24809.

PMID:
24633904
18.

Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptional modulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor β (TGF-β1) signaling axis.

Mascareno E, Galatioto J, Rozenberg I, Salciccioli L, Kamran H, Lazar JM, Liu F, Pedrazzini T, Siddiqui MA.

J Biol Chem. 2012 Apr 13;287(16):13084-93. doi: 10.1074/jbc.M111.288944. Epub 2012 Feb 3.

19.
20.

Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model.

Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K.

J Cell Physiol. 2005 May;203(2):447-56.

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