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Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism.

Cheng PW, Ho WY, Su YT, Lu PJ, Chen BZ, Cheng WH, Lu WH, Sun GC, Yeh TC, Hsiao M, Tseng CJ.

Br J Pharmacol. 2014 Jun;171(11):2739-50. doi: 10.1111/bph.12648.


Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension.

Cheng PW, Lee HC, Lu PJ, Chen HH, Lai CC, Sun GC, Yeh TC, Hsiao M, Lin YT, Liu CP, Tseng CJ.

Sci Rep. 2016 May 3;6:25342. doi: 10.1038/srep25342.


Resveratrol Regulates Blood Pressure by Enhancing AMPK Signaling to Downregulate a Rac1-Derived NADPH Oxidase in the Central Nervous System.

Yeh TC, Shin CS, Chen HH, Lai CC, Sun GC, Tseng CJ, Cheng PW.

J Appl Physiol (1985). 2018 Mar 1. doi: 10.1152/japplphysiol.00686.2017. [Epub ahead of print]


Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.

Nozoe M, Hirooka Y, Koga Y, Sagara Y, Kishi T, Engelhardt JF, Sunagawa K.

Hypertension. 2007 Jul;50(1):62-8. Epub 2007 May 21.


Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling.

Yeh TC, Liu CP, Cheng WH, Chen BR, Lu PJ, Cheng PW, Ho WY, Sun GC, Liou JC, Tseng CJ.

Hypertension. 2014 Mar;63(3):535-41. doi: 10.1161/HYPERTENSIONAHA.113.02272. Epub 2013 Dec 23.


Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK.

Guo S, Yao Q, Ke Z, Chen H, Wu J, Liu C.

Mol Cell Endocrinol. 2015 Sep 5;412:85-94. doi: 10.1016/j.mce.2015.05.034. Epub 2015 Jun 6.


Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure.

Cheng WH, Lu PJ, Ho WY, Tung CS, Cheng PW, Hsiao M, Tseng CJ.

Circ Res. 2010 Mar 5;106(4):788-95. doi: 10.1161/CIRCRESAHA.109.208439. Epub 2010 Jan 7.


Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling.

Ou HC, Lee WJ, Wu CM, Chen JF, Sheu WH.

J Vasc Surg. 2012 Apr;55(4):1104-15. doi: 10.1016/j.jvs.2011.10.011. Epub 2012 Jan 14.


Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro.

Guo R, Li W, Liu B, Li S, Zhang B, Xu Y.

Med Sci Monit Basic Res. 2014 Jun 27;20:82-92. doi: 10.12659/MSMBR.890858.


Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.

Wu KL, Chao YM, Tsay SJ, Chen CH, Chan SH, Dovinova I, Chan JY.

Hypertension. 2014 Oct;64(4):815-24. doi: 10.1161/HYPERTENSIONAHA.114.03777. Epub 2014 Jun 23.


Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats.

Bhatt SR, Lokhandwala MF, Banday AA.

Eur J Pharmacol. 2011 Sep 30;667(1-3):258-64. doi: 10.1016/j.ejphar.2011.05.026. Epub 2011 May 27.


AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

Wang S, Zhang M, Liang B, Xu J, Xie Z, Liu C, Viollet B, Yan D, Zou MH.

Circ Res. 2010 Apr 2;106(6):1117-28. doi: 10.1161/CIRCRESAHA.109.212530. Epub 2010 Feb 18.


Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome.

Ihm SH, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.

Atherosclerosis. 2012 Oct;224(2):377-83. doi: 10.1016/j.atherosclerosis.2012.07.006. Epub 2012 Jul 15.


Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.

Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK.

Pharmacol Res. 2012 Sep;66(3):260-8. doi: 10.1016/j.phrs.2012.05.003. Epub 2012 May 22.


Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice.

Harrison CB, Drummond GR, Sobey CG, Selemidis S.

Clin Exp Pharmacol Physiol. 2010 Apr;37(4):429-34. doi: 10.1111/j.1440-1681.2009.05317.x. Epub 2009 Oct 16.


Resveratrol attenuates oxidative stress induced by balloon injury in the rat carotid artery through actions on the ERK1/2 and NF-kappa B pathway.

Zhang J, Chen J, Yang J, Xu CW, Pu P, Ding JW, Jiang H.

Cell Physiol Biochem. 2013;31(2-3):230-41. doi: 10.1159/000343364. Epub 2013 Feb 14.


Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway.

He T, Xiong J, Nie L, Yu Y, Guan X, Xu X, Xiao T, Yang K, Liu L, Zhang D, Huang Y, Zhang J, Wang J, Sharma K, Zhao J.

J Mol Med (Berl). 2016 Dec;94(12):1359-1371. Epub 2016 Aug 4.


Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats.

Arrick DM, Sun H, Patel KP, Mayhan WG.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H696-703. doi: 10.1152/ajpheart.00312.2011. Epub 2011 Jun 10.

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