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Items: 1 to 20 of 253

1.

Pretreatment with the γ-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling.

Wang M, Ma X, Wang J, Wang L, Wang Y.

Int J Oncol. 2014 Apr;44(4):1401-9. doi: 10.3892/ijo.2014.2301. Epub 2014 Feb 14.

PMID:
24535252
2.

Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780.

Wang M, Wu L, Wang L, Xin X.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):144-9. doi: 10.1016/j.bbrc.2010.01.103. Epub 2010 Feb 1.

PMID:
20117093
3.

Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752.

Chen X, Gong L, Ou R, Zheng Z, Chen J, Xie F, Huang X, Qiu J, Zhang W, Jiang Q, Yang Y, Zhu H, Shi Z, Yan X.

Gynecol Oncol. 2016 Mar;140(3):537-44. doi: 10.1016/j.ygyno.2015.12.011. Epub 2015 Dec 15.

PMID:
26704638
4.

DAPT enhances the apoptosis of human tongue carcinoma cells.

Grottkau BE, Chen XR, Friedrich CC, Yang XM, Jing W, Wu Y, Cai XX, Liu YR, Huang YD, Lin YF.

Int J Oral Sci. 2009 Jun;1(2):81-9. doi: 10.4248/ijos.08025.

5.

Effects of N-[N-(3, 5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) on cell proliferation and apoptosis in Ishikawa endometrial cancer cells.

Mori M, Miyamoto T, Yakushiji H, Ohno S, Miyake Y, Sakaguchi T, Hattori M, Hongo A, Nakaizumi A, Ueda M, Ohno E.

Hum Cell. 2012 Mar;25(1):9-15. doi: 10.1007/s13577-011-0038-8. Epub 2011 Dec 22.

PMID:
22189483
6.

The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway.

Zhang H, Ye Y, Bai Z, Wang S.

Dig Dis Sci. 2008 Aug;53(8):2195-203. doi: 10.1007/s10620-007-0139-0. Epub 2008 Mar 5.

PMID:
18320325
7.

MAML1 regulates cell viability via the NF-κB pathway in cervical cancer cell lines.

Kuncharin Y, Sangphech N, Kueanjinda P, Bhattarakosol P, Palaga T.

Exp Cell Res. 2011 Aug 1;317(13):1830-40. doi: 10.1016/j.yexcr.2011.05.005. Epub 2011 May 24.

PMID:
21640102
8.

[Notch signaling pathway blocked by gamma-secretase inhibitor and its effect on the growth and apoptosis of SKOV3 cells].

Lu YL, Xie C.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;45(4):578-81, 611. Chinese.

PMID:
25286679
9.

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway.

Liu M, Qi Z, Liu B, Ren Y, Li H, Yang G, Zhang Q.

Oncotarget. 2015 Sep 22;6(28):25281-94. doi: 10.18632/oncotarget.4634.

10.

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression.

Ma S, Tan W, Du B, Liu W, Li W, Che D, Zhang G.

Mol Med Rep. 2016 Apr;13(4):3342-8. doi: 10.3892/mmr.2016.4897. Epub 2016 Feb 16.

PMID:
26935490
11.

[Combined inhibition of PI3K and MEK has synergistic inhibitory effect on the proliferation of cisplatin-resistant ovarian cancer cells].

Liu Y, Chen X, Luo Z.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun;30(6):592-6. Chinese.

PMID:
24909280
12.

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.

Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Rivera BK, Kálai T, Hideg K, Kuppusamy P.

Cancer Biol Ther. 2011 Nov 1;12(9):837-45. doi: 10.4161/cbt.12.9.17713. Epub 2011 Nov 1.

PMID:
21885917
13.

Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition.

Yang Y, Duan W, Liang Z, Yi W, Yan J, Wang N, Li Y, Chen W, Yu S, Jin Z, Yi D.

Cell Signal. 2013 Mar;25(3):615-29. doi: 10.1016/j.cellsig.2012.11.025. Epub 2012 Dec 5.

PMID:
23219912
14.

γ-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway.

Li JY, Li RJ, Wang HD.

Acta Pharmacol Sin. 2014 Jun;35(6):825-31. doi: 10.1038/aps.2013.195. Epub 2014 May 5.

15.
16.

Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species.

Yang YI, Kim JH, Lee KT, Choi JH.

Gynecol Oncol. 2011 Dec;123(3):588-96. doi: 10.1016/j.ygyno.2011.08.031. Epub 2011 Sep 25.

PMID:
21945308
17.

Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer.

Su F, Zhu S, Ruan J, Muftuoglu Y, Zhang L, Yuan Q.

Oncotarget. 2016 Jan 26;7(4):4142-54. doi: 10.18632/oncotarget.6769.

18.

Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy.

Liu J, Mao Z, Huang J, Xie S, Liu T, Mao Z.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. doi: 10.1016/j.bbrc.2014.01.164. Epub 2014 Feb 3.

PMID:
24502949
19.

Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma.

Guo Z, Jin X, Jia H.

J Exp Clin Cancer Res. 2013 May 9;32:26. doi: 10.1186/1756-9966-32-26.

20.

Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells.

Han B, Liu SH, Guo WD, Zhang B, Wang JP, Cao YK, Liu J.

World J Gastroenterol. 2015 Sep 7;21(33):9727-35. doi: 10.3748/wjg.v21.i33.9727.

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