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Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.

Gu M, Ouyang C, Lin W, Zhang T, Cao X, Xia Z, Wang X.

J Immunol. 2014 Mar 15;192(6):2846-56. doi: 10.4049/jimmunol.1302537. Epub 2014 Feb 17. Erratum in: J Immunol. 2015 Aug 1;195(3):1331-2.


Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation.

Zhang P, Liu X, Li Y, Zhu X, Zhan Z, Meng J, Li N, Cao X.

J Immunol. 2013 Feb 15;190(4):1685-94. doi: 10.4049/jimmunol.1202384. Epub 2013 Jan 7.


Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.

Gu M, Zhang T, lin W, Liu Z, Lai R, Xia D, Huang H, Wang X.

Cell Signal. 2014 Dec;26(12):2930-9. doi: 10.1016/j.cellsig.2014.09.007. Epub 2014 Sep 17.


S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway.

Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E, Lee KY.

Mol Cell Biol. 2014 Feb;34(3):510-21. doi: 10.1128/MCB.01225-13. Epub 2013 Nov 25.


Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation.

Wang C, Liu X, Liu Y, Zhang Q, Yao Z, Huang B, Zhang P, Li N, Cao X.

J Biol Chem. 2013 Aug 23;288(34):24600-8. doi: 10.1074/jbc.M113.473397. Epub 2013 Jul 15.


CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.

Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X.

Blood. 2008 Dec 15;112(13):4961-70. doi: 10.1182/blood-2008-03-144022. Epub 2008 Sep 25.


Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages.

Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X.

J Immunol. 2010 Jun 1;184(11):6447-56. doi: 10.4049/jimmunol.0901750. Epub 2010 Apr 30.


Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX).

Ouyang C, Nie L, Gu M, Wu A, Han X, Wang X, Shao J, Xia Z.

J Biol Chem. 2014 Aug 29;289(35):24226-37. doi: 10.1074/jbc.M114.559963. Epub 2014 Jul 15.


Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE.

J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16.


Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.

Xu H, An H, Hou J, Han C, Wang P, Yu Y, Cao X.

Mol Immunol. 2008 Aug;45(13):3545-52. doi: 10.1016/j.molimm.2008.05.006. Epub 2008 Jun 20.


WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

Gao D, Wang R, Li B, Yang Y, Zhai Z, Chen DY.

Cell Mol Life Sci. 2009 Aug;66(15):2573-84. doi: 10.1007/s00018-009-0059-6. Epub 2009 Jun 12.


Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation.

Zhang Q, Wang C, Liu Z, Liu X, Han C, Cao X, Li N.

J Biol Chem. 2012 Feb 24;287(9):6208-17. doi: 10.1074/jbc.M111.310375. Epub 2011 Dec 28.


Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.


Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands.

Arsenault RJ, Kogut MH, He H.

Cell Signal. 2013 Nov;25(11):2246-54. doi: 10.1016/j.cellsig.2013.07.014. Epub 2013 Jul 19.


Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.

Shi L, Zhang Z, Fang S, Xu J, Liu J, Shen J, Fang F, Luo L, Yin Z.

Mol Immunol. 2009 Feb;46(4):541-50. doi: 10.1016/j.molimm.2008.07.019. Epub 2008 Oct 31.


Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling.

Moon G, Kim J, Min Y, Wi SM, Shim JH, Chun E, Lee KY.

Cell Signal. 2015 Dec;27(12):2524-33. doi: 10.1016/j.cellsig.2015.09.018. Epub 2015 Sep 30.


High glucose induced-macrophage activation through TGF-β-activated kinase 1 signaling pathway.

Xu X, Qi X, Shao Y, Li Y, Fu X, Feng S, Wu Y.

Inflamm Res. 2016 Aug;65(8):655-64. doi: 10.1007/s00011-016-0948-8. Epub 2016 May 6.


Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts.

Geurts J, van den Brand BT, Wolf A, Abdollahi-Roodsaz S, Arntz OJ, Kracht M, van den Berg WB, van de Loo FA.

Rheumatology (Oxford). 2011 Jul;50(7):1216-25. doi: 10.1093/rheumatology/ker021. Epub 2011 Feb 18.


SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X.

Immunity. 2006 Dec;25(6):919-28. Epub 2006 Dec 7.


AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals.

Kim SY, Jeong S, Jung E, Baik KH, Chang MH, Kim SA, Shim JH, Chun E, Lee KY.

Cell Death Dis. 2012 Jul 26;3:e357. doi: 10.1038/cddis.2012.95.

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