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The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

Sahni S, Bae DH, Lane DJ, Kovacevic Z, Kalinowski DS, Jansson PJ, Richardson DR.

J Biol Chem. 2014 Apr 4;289(14):9692-709. doi: 10.1074/jbc.M113.529511. Epub 2014 Feb 15.


Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

Merlot AM, Shafie NH, Yu Y, Richardson V, Jansson PJ, Sahni S, Lane DJ, Kovacevic Z, Kalinowski DS, Richardson DR.

Biochem Pharmacol. 2016 Jun 1;109:27-47. doi: 10.1016/j.bcp.2016.04.001. Epub 2016 Apr 6.


The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).

Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z, Richardson DR.

J Biol Chem. 2012 May 18;287(21):17016-28. doi: 10.1074/jbc.M112.350470. Epub 2012 Mar 27.


Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.

Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR.

Mol Pharmacol. 2013 Feb;83(2):454-69. doi: 10.1124/mol.112.083097. Epub 2012 Nov 27.


The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.

Kovacevic Z, Menezes SV, Sahni S, Kalinowski DS, Bae DH, Lane DJ, Richardson DR.

J Biol Chem. 2016 Jan 15;291(3):1029-52. doi: 10.1074/jbc.M115.689653. Epub 2015 Nov 3.


Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

Fang BA, Kovačević Ž, Park KC, Kalinowski DS, Jansson PJ, Lane DJ, Sahni S, Richardson DR.

Biochim Biophys Acta. 2014 Jan;1845(1):1-19. doi: 10.1016/j.bbcan.2013.11.002. Epub 2013 Nov 21. Review.


Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

Wangpu X, Lu J, Xi R, Yue F, Sahni S, Park KC, Menezes S, Huang ML, Zheng M, Kovacevic Z, Richardson DR.

Mol Pharmacol. 2016 May;89(5):521-40. doi: 10.1124/mol.115.103044. Epub 2016 Feb 19.


Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.

Dixon KM, Lui GY, Kovacevic Z, Zhang D, Yao M, Chen Z, Dong Q, Assinder SJ, Richardson DR.

Br J Cancer. 2013 Feb 5;108(2):409-19. doi: 10.1038/bjc.2012.582. Epub 2013 Jan 3.


Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).

Xi R, Pun IH, Menezes SV, Fouani L, Kalinowski DS, Huang ML, Zhang X, Richardson DR, Kovacevic Z.

Mol Pharmacol. 2017 May;91(5):499-517. doi: 10.1124/mol.116.107870. Epub 2017 Mar 8.


The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.

Kovacevic Z, Chikhani S, Lui GY, Sivagurunathan S, Richardson DR.

Antioxid Redox Signal. 2013 Mar 10;18(8):874-87. doi: 10.1089/ars.2011.4273. Epub 2012 May 8.


Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells.

Jiang Q, Li F, Shi K, Wu P, An J, Yang Y, Xu C.

Cell Death Dis. 2014 May 29;5:e1270. doi: 10.1038/cddis.2014.200.


Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2α pathway.

Lv S, Sun EC, Xu QY, Zhang JK, Wu DL.

Biochem Biophys Res Commun. 2015 Oct 23;466(3):406-12. doi: 10.1016/j.bbrc.2015.09.039. Epub 2015 Sep 10.


The Iron Chelator, Dp44mT, Effectively Inhibits Human Oral Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo.

Lee JC, Chiang KC, Feng TH, Chen YJ, Chuang ST, Tsui KH, Chung LC, Juang HH.

Int J Mol Sci. 2016 Aug 31;17(9). pii: E1435. doi: 10.3390/ijms17091435.


The role of NDRG1 in the pathology and potential treatment of human cancers.

Bae DH, Jansson PJ, Huang ML, Kovacevic Z, Kalinowski D, Lee CS, Sahni S, Richardson DR.

J Clin Pathol. 2013 Nov;66(11):911-7. doi: 10.1136/jclinpath-2013-201692. Epub 2013 Jun 8. Review.


Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells.

Jung IR, Choi SE, Jung JG, Lee SA, Han SJ, Kim HJ, Kim DJ, Lee KW, Kang Y.

Mol Cell Endocrinol. 2015 May 15;407:74-84. doi: 10.1016/j.mce.2015.03.007. Epub 2015 Mar 14.


RGS19 converts iron deprivation stress into a growth-inhibitory signal.

Hwang J, Kim HS, Kang BS, Kim DH, Ryoo ZY, Choi SU, Lee S.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):168-75. doi: 10.1016/j.bbrc.2015.06.109. Epub 2015 Jun 23.


α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.

Hasanain M, Bhattacharjee A, Pandey P, Ashraf R, Singh N, Sharma S, Vishwakarma AL, Datta D, Mitra K, Sarkar J.

Cell Death Dis. 2015 Aug 27;6:e1860. doi: 10.1038/cddis.2015.219.


ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T.

Cell Death Differ. 2007 Feb;14(2):230-9. Epub 2006 Jun 23.

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