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Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.

Hiraga S, Alvino GM, Chang F, Lian HY, Sridhar A, Kubota T, Brewer BJ, Weinreich M, Raghuraman MK, Donaldson AD.

Genes Dev. 2014 Feb 15;28(4):372-83. doi: 10.1101/gad.231258.113.


Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity.

Davé A, Cooley C, Garg M, Bianchi A.

Cell Rep. 2014 Apr 10;7(1):53-61. doi: 10.1016/j.celrep.2014.02.019. Epub 2014 Mar 20.


Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.

Mattarocci S, Shyian M, Lemmens L, Damay P, Altintas DM, Shi T, Bartholomew CR, Thomä NH, Hardy CF, Shore D.

Cell Rep. 2014 Apr 10;7(1):62-9. doi: 10.1016/j.celrep.2014.03.010. Epub 2014 Mar 27.


Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.

Alver RC, Chadha GS, Gillespie PJ, Blow JJ.

Cell Rep. 2017 Mar 7;18(10):2508-2520. doi: 10.1016/j.celrep.2017.02.042.


Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

Ramer MD, Suman ES, Richter H, Stanger K, Spranger M, Bieberstein N, Duncker BP.

J Biol Chem. 2013 May 24;288(21):14926-35. doi: 10.1074/jbc.M112.392910. Epub 2013 Apr 2.


Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.

Hiraga SI, Ly T, Garzón J, Hořejší Z, Ohkubo YN, Endo A, Obuse C, Boulton SJ, Lamond AI, Donaldson AD.

EMBO Rep. 2017 Mar;18(3):403-419. doi: 10.15252/embr.201641983. Epub 2017 Jan 11.


Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.

Sheu YJ, Kinney JB, Lengronne A, Pasero P, Stillman B.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1899-908. doi: 10.1073/pnas.1404063111. Epub 2014 Apr 16.


The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4.

Sheu YJ, Stillman B.

Nature. 2010 Jan 7;463(7277):113-7. doi: 10.1038/nature08647.


The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.

Bruck I, Kaplan DL.

J Biol Chem. 2015 Jan 9;290(2):1210-21. doi: 10.1074/jbc.M114.608232. Epub 2014 Dec 3. Retraction in: J Biol Chem. 2017 Jun 16;292(24):10320.


Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.

Hoang ML, Leon RP, Pessoa-Brandao L, Hunt S, Raghuraman MK, Fangman WL, Brewer BJ, Sclafani RA.

Mol Cell Biol. 2007 Nov;27(21):7594-602. Epub 2007 Aug 27.


Mechanisms Governing DDK Regulation of the Initiation of DNA Replication.

Larasati, Duncker BP.

Genes (Basel). 2016 Dec 22;8(1). pii: E3. doi: 10.3390/genes8010003. Review.


Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication.

Shyian M, Mattarocci S, Albert B, Hafner L, Lezaja A, Costanzo M, Boone C, Shore D.

PLoS Genet. 2016 Nov 7;12(11):e1006414. doi: 10.1371/journal.pgen.1006414. eCollection 2016 Nov.


At short telomeres Tel1 directs early replication and phosphorylates Rif1.

Sridhar A, Kedziora S, Donaldson AD.

PLoS Genet. 2014 Oct 16;10(10):e1004691. doi: 10.1371/journal.pgen.1004691. eCollection 2014 Oct.


Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes.

Sreesankar E, Senthilkumar R, Bharathi V, Mishra RK, Mishra K.

BMC Genomics. 2012 Jun 19;13:255. doi: 10.1186/1471-2164-13-255.


Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

Bruck I, Kaplan DL.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11223-8. doi: 10.1073/pnas.1509608112. Epub 2015 Aug 24.


Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation.

Deegan TD, Yeeles JT, Diffley JF.

EMBO J. 2016 May 2;35(9):961-73. doi: 10.15252/embj.201593552. Epub 2016 Feb 24.


Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.

Francis LI, Randell JC, Takara TJ, Uchima L, Bell SP.

Genes Dev. 2009 Mar 1;23(5):643-54. doi: 10.1101/gad.1759609.


A novel checkpoint and RPA inhibitory pathway regulated by Rif1.

Xue Y, Rushton MD, Maringele L.

PLoS Genet. 2011 Dec;7(12):e1002417. doi: 10.1371/journal.pgen.1002417. Epub 2011 Dec 15.


A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.

Bruck I, Dhingra N, Kaplan DL.

J Biol Chem. 2017 Feb 24;292(8):3062-3073. doi: 10.1074/jbc.M116.772368. Epub 2017 Jan 12.

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