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Items: 1 to 20 of 105

1.

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR.

J Clin Invest. 2014 Mar;124(3):1057-68. doi: 10.1172/JCI71863. Epub 2014 Feb 17.

2.

Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.

Abu Jawdeh BG, Khan S, Deschênes I, Hoshi M, Goel M, Lock JT, Shinlapawittayatorn K, Babcock G, Lakhe-Reddy S, DeCaro G, Yadav SP, Mohan ML, Naga Prasad SV, Schilling WP, Ficker E, Schelling JR.

J Biol Chem. 2011 Dec 9;286(49):42435-45. doi: 10.1074/jbc.M110.212845. Epub 2011 Oct 21.

3.

Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.

Parker MD, Myers EJ, Schelling JR.

Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub 2015 Feb 14. Review.

4.

A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.

Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL.

J Biol Chem. 2016 Nov 11;291(46):24096-24104. Epub 2016 Sep 20.

PMID:
27650500
5.

Regulation of cell survival by Na+/H+ exchanger-1.

Schelling JR, Abu Jawdeh BG.

Am J Physiol Renal Physiol. 2008 Sep;295(3):F625-32. doi: 10.1152/ajprenal.90212.2008. Epub 2008 May 14. Review.

6.

The NHE1 Na+/H+ exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains.

Khan S, Wu KL, Sedor JR, Abu Jawdeh BG, Schelling JR.

Cell Mol Biol (Noisy-le-grand). 2006 Dec 30;52(8):115-21.

PMID:
17535745
7.

Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds.

Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Hirayama N, Wakabayashi S.

Mol Pharmacol. 2014 Jan;85(1):18-28. doi: 10.1124/mol.113.089268. Epub 2013 Oct 17.

8.

Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger.

Wu KL, Khan S, Lakhe-Reddy S, Wang L, Jarad G, Miller RT, Konieczkowski M, Brown AM, Sedor JR, Schelling JR.

Am J Physiol Renal Physiol. 2003 Apr;284(4):F829-39. Epub 2002 Nov 26.

9.

RhoA and MAPK signal transduction pathways regulate NHE1-dependent proximal tubule cell apoptosis after mechanical stretch.

Bocanegra V, Gil Lorenzo AF, Cacciamani V, Benardón ME, Costantino VV, Vallés PG.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F881-9. doi: 10.1152/ajprenal.00232.2014. Epub 2014 Jul 30.

10.

Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

Damkier HH, Prasad V, Hübner CA, Praetorius J.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1291-300. doi: 10.1152/ajpcell.00062.2009. Epub 2009 Apr 15.

11.

Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice.

Gangadharan Komala M, Gross S, Mudaliar H, Huang C, Pegg K, Mather A, Shen S, Pollock CA, Panchapakesan U.

PLoS One. 2014 Nov 4;9(11):e108994. doi: 10.1371/journal.pone.0108994. eCollection 2014.

12.

Activation of the apical Na+/H+ exchanger NHE3 by formate: a basis of enhanced fluid and electrolyte reabsorption by formate in the kidney.

Petrovic S, Barone S, Weinstein AM, Soleimani M.

Am J Physiol Renal Physiol. 2004 Aug;287(2):F336-46. Epub 2004 Apr 13.

13.

PI-PLCbeta is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II.

Rangel LB, Lopes AG, Lara LS, Carvalho TL, Silva IV, Oliveira MM, Einicker-Lamas M, Vieyra A, Nogaroli L, Caruso-Neves C.

Regul Pept. 2005 Apr 15;127(1-3):177-82.

PMID:
15680484
14.
15.

Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy.

Brezniceanu ML, Lau CJ, Godin N, Chénier I, Duclos A, Ethier J, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

J Am Soc Nephrol. 2010 Jun;21(6):943-54. doi: 10.1681/ASN.2009030242. Epub 2010 Mar 18.

16.

Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin.

Li X, Prins D, Michalak M, Fliegel L.

Am J Physiol Cell Physiol. 2013 Dec 1;305(11):C1161-9. doi: 10.1152/ajpcell.00208.2013. Epub 2013 Oct 2.

17.

Oxidative Stress-Activated NHE1 Is Involved in High Glucose-Induced Apoptosis in Renal Tubular Epithelial Cells.

Wu Y, Zhang M, Liu R, Zhao C.

Yonsei Med J. 2016 Sep;57(5):1252-9. doi: 10.3349/ymj.2016.57.5.1252.

18.

Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+.

Köster S, Pavkov-Keller T, Kühlbrandt W, Yildiz Ö.

J Biol Chem. 2011 Nov 25;286(47):40954-61. doi: 10.1074/jbc.M111.286906. Epub 2011 Sep 19.

19.

Acidosis-mediated regulation of the NHE1 isoform of the Na⁺/H⁺ exchanger in renal cells.

Odunewu A, Fliegel L.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F370-81. doi: 10.1152/ajprenal.00598.2012. Epub 2013 May 15.

20.

Phosphorylation and activation of the plasma membrane Na+/H+ exchanger (NHE1) during osmotic cell shrinkage.

Rigor RR, Damoc C, Phinney BS, Cala PM.

PLoS One. 2011;6(12):e29210. doi: 10.1371/journal.pone.0029210. Epub 2011 Dec 28.

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