Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 105


Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR.

J Clin Invest. 2014 Mar;124(3):1057-68. doi: 10.1172/JCI71863. Epub 2014 Feb 17.


Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.

Abu Jawdeh BG, Khan S, Deschênes I, Hoshi M, Goel M, Lock JT, Shinlapawittayatorn K, Babcock G, Lakhe-Reddy S, DeCaro G, Yadav SP, Mohan ML, Naga Prasad SV, Schilling WP, Ficker E, Schelling JR.

J Biol Chem. 2011 Dec 9;286(49):42435-45. doi: 10.1074/jbc.M110.212845. Epub 2011 Oct 21.


Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.

Parker MD, Myers EJ, Schelling JR.

Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub 2015 Feb 14. Review.


A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.

Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL.

J Biol Chem. 2016 Nov 11;291(46):24096-24104. Epub 2016 Sep 20.


Regulation of cell survival by Na+/H+ exchanger-1.

Schelling JR, Abu Jawdeh BG.

Am J Physiol Renal Physiol. 2008 Sep;295(3):F625-32. doi: 10.1152/ajprenal.90212.2008. Epub 2008 May 14. Review.


The NHE1 Na+/H+ exchanger regulates cell survival by activating and targeting ezrin to specific plasma membrane domains.

Khan S, Wu KL, Sedor JR, Abu Jawdeh BG, Schelling JR.

Cell Mol Biol (Noisy-le-grand). 2006 Dec 30;52(8):115-21.


Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds.

Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Hirayama N, Wakabayashi S.

Mol Pharmacol. 2014 Jan;85(1):18-28. doi: 10.1124/mol.113.089268. Epub 2013 Oct 17.


Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger.

Wu KL, Khan S, Lakhe-Reddy S, Wang L, Jarad G, Miller RT, Konieczkowski M, Brown AM, Sedor JR, Schelling JR.

Am J Physiol Renal Physiol. 2003 Apr;284(4):F829-39. Epub 2002 Nov 26.


RhoA and MAPK signal transduction pathways regulate NHE1-dependent proximal tubule cell apoptosis after mechanical stretch.

Bocanegra V, Gil Lorenzo AF, Cacciamani V, Benardón ME, Costantino VV, Vallés PG.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F881-9. doi: 10.1152/ajprenal.00232.2014. Epub 2014 Jul 30.


Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

Damkier HH, Prasad V, Hübner CA, Praetorius J.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1291-300. doi: 10.1152/ajpcell.00062.2009. Epub 2009 Apr 15.


Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice.

Gangadharan Komala M, Gross S, Mudaliar H, Huang C, Pegg K, Mather A, Shen S, Pollock CA, Panchapakesan U.

PLoS One. 2014 Nov 4;9(11):e108994. doi: 10.1371/journal.pone.0108994. eCollection 2014.


Activation of the apical Na+/H+ exchanger NHE3 by formate: a basis of enhanced fluid and electrolyte reabsorption by formate in the kidney.

Petrovic S, Barone S, Weinstein AM, Soleimani M.

Am J Physiol Renal Physiol. 2004 Aug;287(2):F336-46. Epub 2004 Apr 13.


PI-PLCbeta is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II.

Rangel LB, Lopes AG, Lara LS, Carvalho TL, Silva IV, Oliveira MM, Einicker-Lamas M, Vieyra A, Nogaroli L, Caruso-Neves C.

Regul Pept. 2005 Apr 15;127(1-3):177-82.


Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy.

Brezniceanu ML, Lau CJ, Godin N, Chénier I, Duclos A, Ethier J, Filep JG, Ingelfinger JR, Zhang SL, Chan JS.

J Am Soc Nephrol. 2010 Jun;21(6):943-54. doi: 10.1681/ASN.2009030242. Epub 2010 Mar 18.


Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin.

Li X, Prins D, Michalak M, Fliegel L.

Am J Physiol Cell Physiol. 2013 Dec 1;305(11):C1161-9. doi: 10.1152/ajpcell.00208.2013. Epub 2013 Oct 2.


Oxidative Stress-Activated NHE1 Is Involved in High Glucose-Induced Apoptosis in Renal Tubular Epithelial Cells.

Wu Y, Zhang M, Liu R, Zhao C.

Yonsei Med J. 2016 Sep;57(5):1252-9. doi: 10.3349/ymj.2016.57.5.1252.


Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+.

Köster S, Pavkov-Keller T, Kühlbrandt W, Yildiz Ö.

J Biol Chem. 2011 Nov 25;286(47):40954-61. doi: 10.1074/jbc.M111.286906. Epub 2011 Sep 19.


Acidosis-mediated regulation of the NHE1 isoform of the Na⁺/H⁺ exchanger in renal cells.

Odunewu A, Fliegel L.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F370-81. doi: 10.1152/ajprenal.00598.2012. Epub 2013 May 15.


Phosphorylation and activation of the plasma membrane Na+/H+ exchanger (NHE1) during osmotic cell shrinkage.

Rigor RR, Damoc C, Phinney BS, Cala PM.

PLoS One. 2011;6(12):e29210. doi: 10.1371/journal.pone.0029210. Epub 2011 Dec 28.

Supplemental Content

Support Center