Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 130

1.

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Dang HT, Chorell E, Uvell H, Pinkner JS, Hultgren SJ, Almqvist F.

Org Biomol Chem. 2014 Mar 28;12(12):1942-56. doi: 10.1039/c3ob42478b.

2.

Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: structure-based optimization of a virtual screening hit.

Sahner JH, Groh M, Negri M, Haupenthal J, Hartmann RW.

Eur J Med Chem. 2013 Jul;65:223-31. doi: 10.1016/j.ejmech.2013.04.060.

PMID:
23711833
3.

Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.

Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F.

J Med Chem. 2010 Aug 12;53(15):5690-5. doi: 10.1021/jm100470t.

4.

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.

Eur J Med Chem. 2014 Feb 12;73:83-96. doi: 10.1016/j.ejmech.2013.11.031.

PMID:
24384549
5.

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013.

PMID:
23786712
6.

Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.

Bozorov K, Ma HR, Zhao JY, Zhao HQ, Chen H, Bobakulov K, Xin XL, Elmuradov B, Shakhidoyatov K, Aisa HA.

Eur J Med Chem. 2014 Sep 12;84:739-45. doi: 10.1016/j.ejmech.2014.07.065.

PMID:
25064350
7.

Synthesis and antibacterial activity of some new thiazole and thiophene derivatives.

Khalil AM, Berghot MA, Gouda MA.

Eur J Med Chem. 2009 Nov;44(11):4434-40. doi: 10.1016/j.ejmech.2009.06.002.

PMID:
19581025
8.
9.

Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.

Aberg V, Fällman E, Axner O, Uhlin BE, Hultgren SJ, Almqvist F.

Mol Biosyst. 2007 Mar;3(3):214-8.

PMID:
17308668
10.

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.

Berg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3536-40. doi: 10.1016/j.bmcl.2008.05.020.

11.

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.

Chorell E, Pinkner JS, Bengtsson C, Banchelin TS, Edvinsson S, Linusson A, Hultgren SJ, Almqvist F.

Bioorg Med Chem. 2012 May 1;20(9):3128-42. doi: 10.1016/j.bmc.2012.01.048.

12.

Antibacterial activity of thioetherhydroxyethylsulfonamide derivatives.

Vellasco WT Jr, Guedes GP, Facchinetti V, Vasconcelos TR, Vaz MG, Cunico W, de Souza MV, de Paula GR, Fleming ME, Gomes CR.

Med Chem. 2014 May;10(3):271-6.

PMID:
24533504
13.

From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription initiation complex formation.

Thach O, Mielczarek M, Ma C, Kutty SK, Yang X, Black DS, Griffith R, Lewis PJ, Kumar N.

Bioorg Med Chem. 2016 Mar 15;24(6):1171-82. doi: 10.1016/j.bmc.2016.01.040.

PMID:
26860928
14.

Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory.

Zhang F, Wen Q, Wang SF, Shahla Karim B, Yang YS, Liu JJ, Zhang WM, Zhu HL.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):90-5. doi: 10.1016/j.bmcl.2013.11.079.

PMID:
24332628
15.
16.

Design, synthesis and evaluation of N-aryl-glyoxamide derivatives as structurally novel bacterial quorum sensing inhibitors.

Nizalapur S, Kimyon Ö, Biswas NN, Gardner CR, Griffith R, Rice SA, Manefield M, Willcox M, Black DS, Kumar N.

Org Biomol Chem. 2016 Jan 14;14(2):680-93. doi: 10.1039/c5ob01973g.

PMID:
26552577
17.

Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms.

Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LB, Hultgren SJ, Almqvist F.

Chemistry. 2012 Apr 10;18(15):4522-32. doi: 10.1002/chem.201103936.

18.

Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric Acid.

Cattò C, Dell'Orto S, Villa F, Villa S, Gelain A, Vitali A, Marzano V, Baroni S, Forlani F, Cappitelli F.

PLoS One. 2015 Jul 1;10(7):e0131519. doi: 10.1371/journal.pone.0131519. Erratum in: PLoS One. 2015;10(8):e0136124.

19.

Pilicides-small molecules targeting bacterial virulence.

Aberg V, Almqvist F.

Org Biomol Chem. 2007 Jun 21;5(12):1827-34.

PMID:
17551629
20.

Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents.

Zhang L, Chai X, Wang B, Yu S, Hu H, Zou Y, Zhao Q, Meng Q, Wu Q.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5057-60. doi: 10.1016/j.bmcl.2013.07.042.

PMID:
23937982
Items per page

Supplemental Content

Support Center