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Items: 1 to 20 of 130

1.

Competing aggregation pathways for monoclonal antibodies.

Wu H, Kroe-Barrett R, Singh S, Robinson AS, Roberts CJ.

FEBS Lett. 2014 Mar 18;588(6):936-41. doi: 10.1016/j.febslet.2014.01.051. Epub 2014 Feb 12.

2.

Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.

Kim N, Remmele RL Jr, Liu D, Razinkov VI, Fernandez EJ, Roberts CJ.

Biophys Chem. 2013 Feb;172:26-36. doi: 10.1016/j.bpc.2012.12.004. Epub 2012 Dec 26.

PMID:
23334430
3.

Folding of the Fab fragment within the intact antibody.

Lilie H.

FEBS Lett. 1997 Nov 10;417(2):239-42.

4.

Effect of posttranslational modifications on the thermal stability of a recombinant monoclonal antibody.

Liu H, Bulseco GG, Sun J.

Immunol Lett. 2006 Aug 15;106(2):144-53. Epub 2006 Jun 27.

PMID:
16831470
5.

The unfolding/denaturation of immunogammaglobulin of isotype 2b and its F(ab) and F(c) fragments.

Vermeer AW, Norde W, van Amerongen A.

Biophys J. 2000 Oct;79(4):2150-4.

6.

Perturbation of thermal unfolding and aggregation of human IgG1 Fc fragment by Hofmeister anions.

Zhang-van Enk J, Mason BD, Yu L, Zhang L, Hamouda W, Huang G, Liu D, Remmele RL Jr, Zhang J.

Mol Pharm. 2013 Feb 4;10(2):619-30. doi: 10.1021/mp300378y. Epub 2013 Jan 17.

PMID:
23256580
7.

Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments.

Welfle K, Misselwitz R, Hausdorf G, Höhne W, Welfle H.

Biochim Biophys Acta. 1999 Apr 12;1431(1):120-31.

PMID:
10209285
8.

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition.

Nishi H, Miyajima M, Wakiyama N, Kubota K, Hasegawa J, Uchiyama S, Fukui K.

J Biosci Bioeng. 2011 Oct;112(4):326-32. doi: 10.1016/j.jbiosc.2011.06.017. Epub 2011 Jul 23.

PMID:
21783411
9.

Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations.

Wang X, Kumar S, Buck PM, Singh SK.

Proteins. 2013 Mar;81(3):443-60. doi: 10.1002/prot.24202. Epub 2012 Nov 12.

PMID:
23065923
10.

Quantitative glycan profiling of normal human plasma derived immunoglobulin and its fragments Fab and Fc.

Anumula KR.

J Immunol Methods. 2012 Aug 31;382(1-2):167-76. doi: 10.1016/j.jim.2012.05.022. Epub 2012 Jun 6.

PMID:
22683540
11.

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD.

MAbs. 2015;7(1):84-95. doi: 10.4161/19420862.2014.985494.

12.

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity.

Arora J, Hu Y, Esfandiary R, Sathish HA, Bishop SM, Joshi SB, Middaugh CR, Volkin DB, Weis DD.

MAbs. 2016 Nov/Dec;8(8):1561-1574. Epub 2016 Aug 25.

13.

Hybrid IgG4/IgG4 Fc antibodies form upon 'Fab-arm' exchange as demonstrated by SDS-PAGE or size-exclusion chromatography.

Rispens T, den Bleker TH, Aalberse RC.

Mol Immunol. 2010 Apr;47(7-8):1592-4. doi: 10.1016/j.molimm.2010.02.021. Epub 2010 Mar 17.

PMID:
20299101
14.
15.

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.

Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB.

MAbs. 2015;7(3):525-39. doi: 10.1080/19420862.2015.1029217.

16.

Mouse IgG2b monoclonal antibody fragmentation. Preparation and purification of Fab, Fc and Fab/c fragments.

Demignot S, Garnett MC, Baldwin RW.

J Immunol Methods. 1989 Jul 26;121(2):209-17.

PMID:
2503561
17.

Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1.

Wu H, Truncali K, Ritchie J, Kroe-Barrett R, Singh S, Robinson AS, Roberts CJ.

MAbs. 2015;7(6):1072-83. doi: 10.1080/19420862.2015.1079678. Epub 2015 Aug 12.

18.

Refined structure of an intact IgG2a monoclonal antibody.

Harris LJ, Larson SB, Hasel KW, McPherson A.

Biochemistry. 1997 Feb 18;36(7):1581-97.

PMID:
9048542
19.

Effects of temperature and osmolytes on competing degradation routes for an IgG1 antibody.

Roberts CJ, Nesta DP, Kim N.

J Pharm Sci. 2013 Oct;102(10):3556-66. doi: 10.1002/jps.23668. Epub 2013 Jul 19.

PMID:
23873602
20.

Cryoprecipitation properties of a high-affinity monoclonal IgM anti-fluorescyl antibody.

Dombrink-Kurtzman MA, Voss EW Jr.

Mol Immunol. 1988 Dec;25(12):1309-20.

PMID:
3237215

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