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Items: 1 to 20 of 159

1.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors.

Wang NY, Zuo WQ, Xu Y, Gao C, Zeng XX, Zhang LD, You XY, Peng CT, Shen Y, Yang SY, Wei YQ, Yu LT.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1581-8. doi: 10.1016/j.bmcl.2014.01.075. Epub 2014 Feb 3.

PMID:
24529869
2.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Zhang X, Zhang N, Chen G, Turpoff A, Ren H, Takasugi J, Morrill C, Zhu J, Li C, Lennox W, Paget S, Liu Y, Almstead N, Njoroge FG, Gu Z, Komatsu T, Clausen V, Espiritu C, Graci J, Colacino J, Lahser F, Risher N, Weetall M, Nomeir A, Karp GM.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3947-53. doi: 10.1016/j.bmcl.2013.04.049. Epub 2013 Apr 30.

PMID:
23683597
3.

Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.

Jin G, Lee S, Choi M, Son S, Kim GW, Oh JW, Lee C, Lee K.

Eur J Med Chem. 2014 Mar 21;75:413-25. doi: 10.1016/j.ejmech.2014.01.062. Epub 2014 Jan 31.

PMID:
24561671
4.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24.

PMID:
14684311
5.

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.

Chen G, Ren H, Zhang N, Lennox W, Turpoff A, Paget S, Li C, Almstead N, Njoroge FG, Gu Z, Graci J, Jung SP, Colacino J, Lahser F, Zhao X, Weetall M, Nomeir A, Karp GM.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):781-6. doi: 10.1016/j.bmcl.2014.12.093. Epub 2015 Jan 7.

PMID:
25613678
6.

Synthesis and anti-HCV activity evaluation of anilinoquinoline derivatives.

Peng HK, Lin CK, Yang SY, Tseng CK, Tzeng CC, Lee JC, Yang SC.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1107-10. doi: 10.1016/j.bmcl.2011.11.121. Epub 2011 Dec 4.

PMID:
22204909
7.

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.

Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A.

Eur J Med Chem. 2016 Nov 10;123:31-47. doi: 10.1016/j.ejmech.2016.07.035. Epub 2016 Jul 19.

PMID:
27474921
8.

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J.

J Med Chem. 2007 May 3;50(9):2108-16. Epub 2007 Apr 3. Erratum in: J Med Chem. 2007 Nov 29;50(24):6290.

PMID:
17402724
9.

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors.

Enguehard-Gueiffier C, Musiu S, Henry N, Véron JB, Mavel S, Neyts J, Leyssen P, Paeshuyse J, Gueiffier A.

Eur J Med Chem. 2013 Jun;64:448-63. doi: 10.1016/j.ejmech.2013.03.054. Epub 2013 Apr 19.

PMID:
23665801
10.

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

ACS Comb Sci. 2015 Oct 12;17(10):641-52. doi: 10.1021/acscombsci.5b00101. Epub 2015 Sep 17.

PMID:
26332742
11.

Synthesis and hepatitis C antiviral activity of 1-aminobenzyl-1H-indazole-3-carboxamide analogues.

Shi JJ, Ji FH, He PL, Yang YX, Tang W, Zuo JP, Li YC.

ChemMedChem. 2013 May;8(5):722-5. doi: 10.1002/cmdc.201300083. Epub 2013 Mar 19.

PMID:
23512654
12.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F.

J Med Chem. 2006 Mar 9;49(5):1693-705.

PMID:
16509585
13.

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity.

Puerstinger G, Paeshuyse J, Heinrich S, Mohr J, Schraffl N, De Clercq E, Neyts J.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5111-4. Epub 2007 Jul 13.

PMID:
17656093
14.

Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.

Ding Y, Girardet JL, Smith KL, Larson G, Prigaro B, Wu JZ, Yao N.

Bioorg Chem. 2006 Feb;34(1):26-38. Epub 2005 Dec 19.

PMID:
16360193
15.

Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication.

Najda-Bernatowicz A, Krawczyk M, Stankiewicz-Drogoń A, Bretner M, Boguszewska-Chachulska AM.

Bioorg Med Chem. 2010 Jul 15;18(14):5129-36. doi: 10.1016/j.bmc.2010.05.066. Epub 2010 Jun 2.

PMID:
20579888
16.

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.

Barreca ML, Manfroni G, Leyssen P, Winquist J, Kaushik-Basu N, Paeshuyse J, Krishnan R, Iraci N, Sabatini S, Tabarrini O, Basu A, Danielson UH, Neyts J, Cecchetti V.

J Med Chem. 2013 Mar 28;56(6):2270-82. doi: 10.1021/jm301643a. Epub 2013 Mar 7.

17.

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization.

Yan W, Qing J, Mei H, Mao F, Huang J, Zhu J, Jiang H, Liu L, Zhang L, Li J.

Molecules. 2015 Jun 4;20(6):10342-59. doi: 10.3390/molecules200610342.

18.

Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates.

Neyts J, De Clercq E, Singha R, Chang YH, Das AR, Chakraborty SK, Hong SC, Tsay SC, Hsu MH, Hwu JR.

J Med Chem. 2009 Mar 12;52(5):1486-90. doi: 10.1021/jm801240d.

PMID:
19193060
19.

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity.

Puerstinger G, Paeshuyse J, De Clercq E, Neyts J.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):390-3. Epub 2006 Oct 19.

PMID:
17084081
20.

Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.

Rawal RK, Katti SB, Kaushik-Basu N, Arora P, Pan Z.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6110-4. doi: 10.1016/j.bmcl.2008.10.023. Epub 2008 Oct 8.

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