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Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

Demetriades C, Doumpas N, Teleman AA.

Cell. 2014 Feb 13;156(4):786-99. doi: 10.1016/j.cell.2014.01.024.


Novel tRNA function in amino acid sensing of yeast Tor complex1.

Kamada Y.

Genes Cells. 2017 Feb;22(2):135-147. doi: 10.1111/gtc.12462. Epub 2017 Jan 13.


Rheb and Rags come together at the lysosome to activate mTORC1.

Groenewoud MJ, Zwartkruis FJ.

Biochem Soc Trans. 2013 Aug;41(4):951-5. doi: 10.1042/BST20130037. Review.


Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Ögmundsdóttir MH, Heublein S, Kazi S, Reynolds B, Visvalingam SM, Shaw MK, Goberdhan DC.

PLoS One. 2012;7(5):e36616. doi: 10.1371/journal.pone.0036616. Epub 2012 May 4.


Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.

Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049.


mTORC1: turning off is just as important as turning on.

Benjamin D, Hall MN.

Cell. 2014 Feb 13;156(4):627-8. doi: 10.1016/j.cell.2014.01.057.


p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Agarwal S, Bell CM, Taylor SM, Moran RG.

Mol Cancer Res. 2016 Jan;14(1):66-77. doi: 10.1158/1541-7786.MCR-15-0159. Epub 2015 Sep 18.


Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.

Jung J, Genau HM, Behrends C.

Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11.


Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Oshiro N, Rapley J, Avruch J.

J Biol Chem. 2014 Jan 31;289(5):2658-74. doi: 10.1074/jbc.M113.528505. Epub 2013 Dec 11.


Lysosomal recruitment of TSC2 is a universal response to cellular stress.

Demetriades C, Plescher M, Teleman AA.

Nat Commun. 2016 Feb 12;7:10662. doi: 10.1038/ncomms10662.


Rag GTPase in amino acid signaling.

Kim J, Kim E.

Amino Acids. 2016 Apr;48(4):915-28. doi: 10.1007/s00726-016-2171-x. Epub 2016 Jan 18. Review.


Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids.

Averous J, Lambert-Langlais S, Carraro V, Gourbeyre O, Parry L, B'Chir W, Muranishi Y, Jousse C, Bruhat A, Maurin AC, Proud CG, Fafournoux P.

Cell Signal. 2014 Sep;26(9):1918-27. doi: 10.1016/j.cellsig.2014.04.019. Epub 2014 May 2.


Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.

J Biol Chem. 2008 Nov 7;283(45):30482-92. doi: 10.1074/jbc.M803348200. Epub 2008 Aug 1.


Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.

J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22.


Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Review.


Control of cell growth: Rag GTPases in activation of TORC1.

Yang H, Gong R, Xu Y.

Cell Mol Life Sci. 2013 Aug;70(16):2873-85. doi: 10.1007/s00018-012-1195-y. Epub 2012 Dec 16. Review. Erratum in: Cell Mol Life Sci. 2013 Aug;70(16):3041-3.


Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.


Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.


Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.

Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058.


Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.

Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y.

Genes Dev. 2011 Aug 15;25(16):1668-73. doi: 10.1101/gad.16968011. Epub 2011 Aug 4.

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