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Items: 1 to 20 of 248

1.

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU.

Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009.

2.

Autophagy side of MB21D1/cGAS DNA sensor.

Liang Q, Seo GJ, Choi YJ, Ge J, Rodgers MA, Shi M, Jung JU.

Autophagy. 2014 Jun;10(6):1146-7. doi: 10.4161/auto.28769.

3.

Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity.

Huang J, You H, Su C, Li Y, Chen S, Zheng C.

J Virol. 2018 Jul 17;92(15). pii: e00841-18. doi: 10.1128/JVI.00841-18. Print 2018 Aug 1.

PMID:
29793952
4.

The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

Shu C, Li X, Li P.

Cytokine Growth Factor Rev. 2014 Dec;25(6):641-8. doi: 10.1016/j.cytogfr.2014.06.006. Epub 2014 Jun 22. Review.

5.

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41.

Su C, Zheng C.

J Virol. 2017 Feb 28;91(6). pii: e02414-16. doi: 10.1128/JVI.02414-16. Print 2017 Mar 15.

6.

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.

Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J.

Mol Cell. 2016 Oct 6;64(1):105-119. doi: 10.1016/j.molcel.2016.08.025. Epub 2016 Sep 22.

7.

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.

Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.

PLoS One. 2013 Oct 7;8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013.

8.

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.

Chen Q, Sun L, Chen ZJ.

Nat Immunol. 2016 Sep 20;17(10):1142-9. doi: 10.1038/ni.3558. Review.

PMID:
27648547
9.

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.

10.

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE.

Cell Rep. 2013 May 30;3(5):1355-61. doi: 10.1016/j.celrep.2013.05.009. Epub 2013 May 23.

11.

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure.

Gram AM, Sun C, Landman SL, Oosenbrug T, Koppejan HJ, Kwakkenbos MJ, Hoeben RC, Paludan SR, Ressing ME.

Mol Immunol. 2017 Nov;91:225-237. doi: 10.1016/j.molimm.2017.08.025. Epub 2017 Sep 30.

12.

Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway.

Bode C, Fox M, Tewary P, Steinhagen A, Ellerkmann RK, Klinman D, Baumgarten G, Hornung V, Steinhagen F.

Eur J Immunol. 2016 Jul;46(7):1615-21. doi: 10.1002/eji.201546113. Epub 2016 May 27.

13.

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

Kato K, Omura H, Ishitani R, Nureki O.

Annu Rev Biochem. 2017 Jun 20;86:541-566. doi: 10.1146/annurev-biochem-061516-044813. Epub 2017 Apr 7. Review.

PMID:
28399655
14.

Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children.

Wang ZS, Liu YL, Mi N, Duan DY.

Mol Immunol. 2017 Jul;87:76-85. doi: 10.1016/j.molimm.2017.04.007. Epub 2017 Apr 13.

PMID:
28412547
15.

Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P.

Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019.

16.

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ.

Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20.

17.

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.

Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29.

18.

cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling.

Tao J, Zhou X, Jiang Z.

IUBMB Life. 2016 Nov;68(11):858-870. doi: 10.1002/iub.1566. Epub 2016 Oct 5. Review.

19.

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.

Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU.

Cell Host Microbe. 2015 Jun 10;17(6):820-8. doi: 10.1016/j.chom.2015.05.005. Epub 2015 Jun 2.

20.

Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING.

Biolatti M, Dell'Oste V, Pautasso S, Gugliesi F, von Einem J, Krapp C, Jakobsen MR, Borgogna C, Gariglio M, De Andrea M, Landolfo S.

J Virol. 2018 Feb 26;92(6). pii: e01774-17. doi: 10.1128/JVI.01774-17. Print 2018 Mar 15.

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