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Items: 1 to 20 of 146

1.

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU.

Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009.

2.

Autophagy side of MB21D1/cGAS DNA sensor.

Liang Q, Seo GJ, Choi YJ, Ge J, Rodgers MA, Shi M, Jung JU.

Autophagy. 2014 Jun;10(6):1146-7. doi: 10.4161/auto.28769.

3.

The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.

Shu C, Li X, Li P.

Cytokine Growth Factor Rev. 2014 Dec;25(6):641-8. doi: 10.1016/j.cytogfr.2014.06.006. Epub 2014 Jun 22. Review.

4.

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.

Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.

PLoS One. 2013 Oct 7;8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013 Oct 7.

5.

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.

6.

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V.

Nature. 2013 Nov 28;503(7477):530-4. doi: 10.1038/nature12640. Epub 2013 Sep 29.

7.

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ.

Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20.

8.

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE.

Cell Rep. 2013 May 30;3(5):1355-61. doi: 10.1016/j.celrep.2013.05.009. Epub 2013 May 23.

9.

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.

Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU.

Cell Host Microbe. 2015 Jun 10;17(6):820-8. doi: 10.1016/j.chom.2015.05.005. Epub 2015 Jun 2.

10.

Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P.

Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019.

11.

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V.

EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25.

12.

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.

Cai X, Chiu YH, Chen ZJ.

Mol Cell. 2014 Apr 24;54(2):289-96. doi: 10.1016/j.molcel.2014.03.040. Review.

13.

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.

Li T, Cheng H, Yuan H, Xu Q, Shu C, Zhang Y, Xu P, Tan J, Rui Y, Li P, Tan X.

Sci Rep. 2016 Jan 12;6:19049. doi: 10.1038/srep19049.

14.

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Sun L, Wu J, Du F, Chen X, Chen ZJ.

Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20.

15.

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.

Ma F, Li B, Liu SY, Iyer SS, Yu Y, Wu A, Cheng G.

J Immunol. 2015 Feb 15;194(4):1545-54. doi: 10.4049/jimmunol.1402066. Epub 2015 Jan 21.

16.

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.

Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y, Fan Z.

Nat Immunol. 2016 Apr;17(4):369-78. doi: 10.1038/ni.3356. Epub 2016 Feb 1. Erratum in: Nat Immunol. 2016 Apr;17(4):469.

PMID:
26829768
17.

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR.

Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6.

18.

The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.

Zhang Y, Yeruva L, Marinov A, Prantner D, Wyrick PB, Lupashin V, Nagarajan UM.

J Immunol. 2014 Sep 1;193(5):2394-404. doi: 10.4049/jimmunol.1302718. Epub 2014 Jul 28.

19.

Regulation of dsDNA-induced innate immune responses by membrane trafficking.

Saitoh T, Fujita N, Yoshimori T, Akira S.

Autophagy. 2010 Apr;6(3):430-2. Epub 2010 Apr 25.

PMID:
20215874
20.

DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.

Motani K, Ito S, Nagata S.

J Immunol. 2015 May 15;194(10):4914-23. doi: 10.4049/jimmunol.1402705. Epub 2015 Apr 8.

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