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TIRC7 and HLA-DR axis contributes to inflammation in multiple sclerosis.

Frischer JM, Reindl M, Künz B, Berger T, Schmidt S, Milford EL, Knosp E, Lassmann H, Utku N.

Mult Scler. 2014 Aug;20(9):1171-81. doi: 10.1177/1352458514521516. Epub 2014 Feb 13.


HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.

Bulwin GC, Wälter S, Schlawinsky M, Heinemann T, Schulze A, Höhne W, Krause G, Kalka-Moll W, Fraser P, Volk HD, Löhler J, Milford EL, Utku N.

PLoS One. 2008 Feb 13;3(2):e1576. doi: 10.1371/journal.pone.0001576.


TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response.

Utku N, Boerner A, Tomschegg A, Bennai-Sanfourche F, Bulwin GC, Heinemann T, Loehler J, Blumberg RS, Volk HD.

J Immunol. 2004 Aug 15;173(4):2342-52.


Monoclonal antibody specific for TIRC7 induces donor-specific anergy and prevents rejection of cardiac allografts in mice.

Kumamoto Y, Tomschegg A, Bennai-Sanfourche F, Boerner A, Kaser A, Schmidt-Knosalla I, Heinemann T, Schlawinsky M, Blumberg RS, Volk HD, Utku N.

Am J Transplant. 2004 Apr;4(4):505-14.


T-cell immune response cDNA 7 in allograft rejection and inflammation.

Utku N, Heinemann T, Milford EL.

Curr Opin Investig Drugs. 2007 May;8(5):401-10. Review.


TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats.

Kumamoto Y, Tamura A, Volk HD, Reinke P, Löhler J, Tullius SG, Utku N.

Transpl Immunol. 2006 Nov;16(3-4):238-44. Epub 2006 Oct 11.


TIRC7 pathway as a target for preventing allograft rejection.

Tamura A, Milford EL, Utku N.

Drug News Perspect. 2005 Mar;18(2):103-8. Review.


TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.

Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.

J Immunol. 2006 Nov 15;177(10):6833-41.


T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta.

Durelli L, Conti L, Clerico M, Boselli D, Contessa G, Ripellino P, Ferrero B, Eid P, Novelli F.

Ann Neurol. 2009 May;65(5):499-509. doi: 10.1002/ana.21652.


Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice.

Utku N, Heinemann T, Winter M, Bulwin CG, Schlawinsky M, Fraser P, Nieuwenhuis EE, Volk HD, Blumberg RS.

Clin Exp Immunol. 2006 Apr;144(1):142-51.


Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.

Utku N, Heinemann T, Tullius SG, Bulwin GC, Beinke S, Blumberg RS, Beato F, Randall J, Kojima R, Busconi L, Robertson ES, Schülein R, Volk HD, Milford EL, Gullans SR.

Immunity. 1998 Oct;9(4):509-18.


High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes.

Leussink VI, Jung S, Merschdorf U, Toyka KV, Gold R.

Arch Neurol. 2001 Jan;58(1):91-7.


Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease.

Zhu F, Qiao J, Chen W, Pan B, Wu QY, Cao J, Sang W, Yan ZL, Zeng LY, Li ZY, Xu KL.

Ann Hematol. 2015 Jun;94(6):1025-32. doi: 10.1007/s00277-015-2300-8. Epub 2015 Jan 28.


Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression.

Romme Christensen J, Börnsen L, Ratzer R, Piehl F, Khademi M, Olsson T, Sørensen PS, Sellebjerg F.

PLoS One. 2013;8(3):e57820. doi: 10.1371/journal.pone.0057820. Epub 2013 Mar 1.


Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.

Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J.

J Allergy Clin Immunol. 2017 Sep;140(3):797-808. doi: 10.1016/j.jaci.2016.11.045. Epub 2017 Feb 22.


Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.

Rostami A, Ciric B.

J Neurol Sci. 2013 Oct 15;333(1-2):76-87. doi: 10.1016/j.jns.2013.03.002. Epub 2013 Apr 8. Review.


Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation.

Heinemann T, Bulwin GC, Randall J, Schnieders B, Sandhoff K, Volk HD, Milford E, Gullans SR, Utku N.

Genomics. 1999 May 1;57(3):398-406.


Characterization of IL-10-secreting T cells derived from regulatory CD4+CD25+ cells by the TIRC7 surface marker.

Wakkach A, Augier S, Breittmayer JP, Blin-Wakkach C, Carle GF.

J Immunol. 2008 May 1;180(9):6054-63.


Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

Bar-Or A, Fawaz L, Fan B, Darlington PJ, Rieger A, Ghorayeb C, Calabresi PA, Waubant E, Hauser SL, Zhang J, Smith CH.

Ann Neurol. 2010 Apr;67(4):452-61. doi: 10.1002/ana.21939.


Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

Huang YH, Zozulya AL, Weidenfeller C, Metz I, Buck D, Toyka KV, Brück W, Wiendl H.

Ann Neurol. 2009 Aug;66(2):171-83. doi: 10.1002/ana.21705.


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