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Items: 1 to 20 of 68

1.

Iron: the hard player in diabetes pathophysiology.

Hansen JB, Moen IW, Mandrup-Poulsen T.

Acta Physiol (Oxf). 2014 Apr;210(4):717-32. doi: 10.1111/apha.12256. Review.

PMID:
24521359
2.

Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells.

Lortz S, Schröter S, Stückemann V, Mehmeti I, Lenzen S.

J Mol Endocrinol. 2014 Jun;52(3):301-10. doi: 10.1530/JME-13-0261.

3.

Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.

Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T.

Cell Metab. 2012 Oct 3;16(4):449-61. doi: 10.1016/j.cmet.2012.09.001.

4.

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA.

Mol Cell Endocrinol. 2012 Jul 6;358(1):88-95. doi: 10.1016/j.mce.2012.03.004.

PMID:
22502743
5.

Oxidative stress: the vulnerable beta-cell.

Lenzen S.

Biochem Soc Trans. 2008 Jun;36(Pt 3):343-7. doi: 10.1042/BST0360343. Review.

PMID:
18481954
6.

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.

Koskenkorva-Frank TS, Weiss G, Koppenol WH, Burckhardt S.

Free Radic Biol Med. 2013 Dec;65:1174-94. doi: 10.1016/j.freeradbiomed.2013.09.001. Review.

PMID:
24036104
7.

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

Li N, Frigerio F, Maechler P.

Biochem Soc Trans. 2008 Oct;36(Pt 5):930-4. doi: 10.1042/BST0360930. Review.

PMID:
18793163
8.

Glycaemic variability and pancreatic β-cell dysfunction.

Kohnert KD, Freyse EJ, Salzsieder E.

Curr Diabetes Rev. 2012 Sep;8(5):345-54. Review.

PMID:
22698079
9.

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction.

Gurzov EN, Eizirik DL.

Trends Cell Biol. 2011 Jul;21(7):424-31. doi: 10.1016/j.tcb.2011.03.001. Review.

PMID:
21481590
10.

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

Rolo AP, Palmeira CM.

Toxicol Appl Pharmacol. 2006 Apr 15;212(2):167-78. Review.

PMID:
16490224
11.

Folate deficiency triggers an oxidative-nitrosative stress-mediated apoptotic cell death and impedes insulin biosynthesis in RINm5F pancreatic islet β-cells: relevant to the pathogenesis of diabetes.

Hsu HC, Chiou JF, Wang YH, Chen CH, Mau SY, Ho CT, Chang PJ, Liu TZ, Chen CH.

PLoS One. 2013 Nov 4;8(11):e77931. doi: 10.1371/journal.pone.0077931.

12.

Epigallocatechin-3-gallate protects pro-inflammatory cytokine induced injuries in insulin-producing cells through the mitochondrial pathway.

Zhang Z, Ding Y, Dai X, Wang J, Li Y.

Eur J Pharmacol. 2011 Nov 16;670(1):311-6. doi: 10.1016/j.ejphar.2011.08.033.

PMID:
21925162
13.

Oxidative stress and beta-cell dysfunction.

Drews G, Krippeit-Drews P, Düfer M.

Pflugers Arch. 2010 Sep;460(4):703-18. doi: 10.1007/s00424-010-0862-9. Review.

PMID:
20652307
14.

Of the renin-angiotensin system and reactive oxygen species Type 2 diabetes and angiotensin II inhibition.

Leiter LA, Lewanczuk RZ.

Am J Hypertens. 2005 Jan;18(1):121-8. Review.

PMID:
15691626
15.

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.

Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL, Cardozo AK.

Cell Death Differ. 2012 Nov;19(11):1836-46. doi: 10.1038/cdd.2012.67.

16.

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell.

Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R, Carpinelli A.

Diabetologia. 2009 Dec;52(12):2489-98. doi: 10.1007/s00125-009-1536-z. Review.

PMID:
19809798
17.

Iron and diabetes risk.

Simcox JA, McClain DA.

Cell Metab. 2013 Mar 5;17(3):329-41. doi: 10.1016/j.cmet.2013.02.007. Review.

18.

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.

19.

Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications.

Liu Q, Sun L, Tan Y, Wang G, Lin X, Cai L.

Curr Med Chem. 2009;16(1):113-29. Review.

PMID:
19149565
20.

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

Igoillo-Esteve M, Marselli L, Cunha DA, Ladrière L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M.

Diabetologia. 2010 Jul;53(7):1395-405. doi: 10.1007/s00125-010-1707-y. Erratum in: Diabetologia. 2012 Mar;55(3):863.

PMID:
20369226
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