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Items: 1 to 20 of 166

1.

The role of Cys179-Cys214 disulfide bond in the stability and folding of prion protein: insights from molecular dynamics simulations.

Ning L, Guo J, Jin N, Liu H, Yao X.

J Mol Model. 2014 Feb;20(2):2106. doi: 10.1007/s00894-014-2106-y. Epub 2014 Feb 11.

PMID:
24515720
2.
3.

Structural determinants in prion protein folding and stability.

Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G.

J Mol Biol. 2014 Nov 11;426(22):3796-810. doi: 10.1016/j.jmb.2014.09.017. Epub 2014 Oct 2.

PMID:
25280897
4.

NMR structure of a variant human prion protein with two disulfide bridges.

Zahn R, Güntert P, von Schroetter C, Wüthrich K.

J Mol Biol. 2003 Feb 7;326(1):225-34.

PMID:
12547204
5.

Influence of pH on the human prion protein: insights into the early steps of misfolding.

van der Kamp MW, Daggett V.

Biophys J. 2010 Oct 6;99(7):2289-98. doi: 10.1016/j.bpj.2010.07.063.

6.

The role of disulfide bridge in the folding and stability of the recombinant human prion protein.

Maiti NR, Surewicz WK.

J Biol Chem. 2001 Jan 26;276(4):2427-31. Epub 2000 Nov 7.

7.

Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.

Biljan I, Ilc G, Giachin G, Raspadori A, Zhukov I, Plavec J, Legname G.

J Mol Biol. 2011 Sep 30;412(4):660-73. doi: 10.1016/j.jmb.2011.07.067. Epub 2011 Aug 4.

PMID:
21839748
8.

Influence of the pathogenic mutations T188K/R/A on the structural stability and misfolding of human prion protein: insight from molecular dynamics simulations.

Guo J, Ning L, Ren H, Liu H, Yao X.

Biochim Biophys Acta. 2012 Feb;1820(2):116-23. doi: 10.1016/j.bbagen.2011.11.013. Epub 2011 Nov 29.

PMID:
22155634
9.

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations.

van der Kamp MW, Daggett V.

Top Curr Chem. 2011;305:169-97. doi: 10.1007/128_2011_158. Review.

PMID:
21526434
10.

A role for intermolecular disulfide bonds in prion diseases?

Welker E, Wedemeyer WJ, Scheraga HA.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4334-6. Epub 2001 Mar 27.

11.

Disulfide bond as a structural determinant of prion protein membrane insertion.

Shin JY, Shin JI, Kim JS, Yang YS, Shin YK, Kim KK, Lee S, Kweon DH.

Mol Cells. 2009 Jun 30;27(6):673-80. doi: 10.1007/s10059-009-0089-9. Epub 2009 Jun 12.

12.

Enhanced stability of human prion proteins with two disulfide bridges.

Knowles TP, Zahn R.

Biophys J. 2006 Aug 15;91(4):1494-500. Epub 2006 Jun 2.

13.

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.

Abskharon RN, Giachin G, Wohlkonig A, Soror SH, Pardon E, Legname G, Steyaert J.

J Am Chem Soc. 2014 Jan 22;136(3):937-44. doi: 10.1021/ja407527p. Epub 2014 Jan 8.

PMID:
24400836
14.

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding.

van der Kamp MW, Daggett V.

J Mol Biol. 2010 Dec 10;404(4):732-48. doi: 10.1016/j.jmb.2010.09.060. Epub 2010 Oct 7.

15.

Reversibility of prion misfolding: insights from constant-pH molecular dynamics simulations.

Vila-Viçosa D, Campos SR, Baptista AM, Machuqueiro M.

J Phys Chem B. 2012 Aug 2;116(30):8812-21. doi: 10.1021/jp3034837. Epub 2012 Jul 17.

PMID:
22803931
16.
17.

Diverse effects on the native β-sheet of the human prion protein due to disease-associated mutations.

Chen W, van der Kamp MW, Daggett V.

Biochemistry. 2010 Nov 16;49(45):9874-81. doi: 10.1021/bi101449f. Epub 2010 Oct 22.

18.
19.

Crystal structure of the human prion protein reveals a mechanism for oligomerization.

Knaus KJ, Morillas M, Swietnicki W, Malone M, Surewicz WK, Yee VC.

Nat Struct Biol. 2001 Sep;8(9):770-4.

PMID:
11524679
20.

Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion.

Elmallah MI, Borgmeyer U, Betzel C, Redecke L.

Prion. 2013 Sep-Oct;7(5):404-11. doi: 10.4161/pri.26745. Epub 2013 Oct 9.

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