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AMP-activated protein kinase α2 protects against liver injury from metastasized tumors via reduced glucose deprivation-induced oxidative stress.

Qiu SL, Xiao ZC, Piao CM, Xian YL, Jia LX, Qi YF, Han JH, Zhang YY, Du J.

J Biol Chem. 2014 Mar 28;289(13):9449-59. doi: 10.1074/jbc.M113.543447. Epub 2014 Feb 10.


Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.

Seo K, Ki SH, Shin SM.

Cell Signal. 2015 Jul;27(7):1533-43. doi: 10.1016/j.cellsig.2015.03.003. Epub 2015 Mar 14.


Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.

Lin D, He H, Ji H, Willis J, Willard L, Jiang Y, Medeiros DM, Wark L, Han J, Liu Y, Lu B.

Mol Nutr Food Res. 2014 May;58(5):1005-15. doi: 10.1002/mnfr.201300186. Epub 2014 Jan 22.


Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.

Xie Z, Zhang J, Wu J, Viollet B, Zou MH.

Diabetes. 2008 Dec;57(12):3222-30. doi: 10.2337/db08-0610. Epub 2008 Oct 3.


Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling.

Yang Y, Zhao Z, Liu Y, Kang X, Zhang H, Meng M.

J Gastroenterol Hepatol. 2015 Mar;30(3):609-18. doi: 10.1111/jgh.12723.


Silibinin activates AMP-activated protein kinase to protect neuronal cells from oxygen and glucose deprivation-re-oxygenation.

Xie Z, Ding SQ, Shen YF.

Biochem Biophys Res Commun. 2014 Nov 14;454(2):313-9. doi: 10.1016/j.bbrc.2014.10.080. Epub 2014 Oct 22.


AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.

Jeon SM, Chandel NS, Hay N.

Nature. 2012 May 9;485(7400):661-5. doi: 10.1038/nature11066.


Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells.

Chen MB, Zhang Y, Wei MX, Shen W, Wu XY, Yao C, Lu PH.

Cell Signal. 2013 Oct;25(10):1993-2002. doi: 10.1016/j.cellsig.2013.05.026. Epub 2013 May 25.


Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.

Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Taguchi R, Soga T, Seimiya H.

Am J Pathol. 2013 May;182(5):1800-10. doi: 10.1016/j.ajpath.2013.01.048. Epub 2013 Mar 15.


AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.

Hulo S, Tiesset H, Lancel S, Edmé JL, Viollet B, Sobaszek A, Nevière R.

Respir Res. 2011 May 19;12:64. doi: 10.1186/1465-9921-12-64.


Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes.

Dirkx E, Schwenk RW, Coumans WA, Hoebers N, Angin Y, Viollet B, Bonen A, van Eys GJ, Glatz JF, Luiken JJ.

J Biol Chem. 2012 Feb 17;287(8):5871-81. doi: 10.1074/jbc.M111.281881. Epub 2011 Dec 9.


A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake.

Timmermans AD, Balteau M, Gélinas R, Renguet E, Ginion A, de Meester C, Sakamoto K, Balligand JL, Bontemps F, Vanoverschelde JL, Horman S, Beauloye C, Bertrand L.

Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1619-30. doi: 10.1152/ajpheart.00965.2013. Epub 2014 Apr 18.


Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle.

Wang P, Zhang RY, Song J, Guan YF, Xu TY, Du H, Viollet B, Miao CY.

Diabetes. 2012 May;61(5):1051-61. doi: 10.2337/db11-1180. Epub 2012 Mar 6.


Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.

Murakami R, Murakami H, Kataoka H, Cheng XW, Takahashi R, Numaguchi Y, Murohara T, Okumura K.

Life Sci. 2010 Oct 9;87(15-16):495-500. doi: 10.1016/j.lfs.2010.09.005. Epub 2010 Sep 21.


The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all?

Bonini MG, Gantner BN.

IUBMB Life. 2013 Nov;65(11):889-96. doi: 10.1002/iub.1213. Review.


AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, Mounier R, Andreelli F, Foretz M.

Acta Physiol (Oxf). 2009 May;196(1):81-98. doi: 10.1111/j.1748-1716.2009.01970.x. Epub 2009 Feb 19. Review.


Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.

Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K.

J Biol Chem. 2012 Nov 23;287(48):40441-7. doi: 10.1074/jbc.M112.384545. Epub 2012 Sep 28.

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