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Items: 1 to 20 of 99

1.

Stimulators of translation identified during a small molecule screening campaign.

Shin U, Williams DE, Kozakov D, Hall DR, Beglov D, Vajda S, Andersen RJ, Pelletier J.

Anal Biochem. 2014 Feb 15;447:6-14.

2.

Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.

Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE.

Cell. 2005 Sep 23;122(6):901-13.

3.

Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus.

Zhu R, Zhang YB, Zhang QY, Gui JF.

J Virol. 2008 Jul;82(14):6889-901. doi: 10.1128/JVI.02385-07. Epub 2008 Apr 30.

4.

Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.

He Y, Tan SL, Tareen SU, Vijaysri S, Langland JO, Jacobs BL, Katze MG.

J Virol. 2001 Jun;75(11):5090-8.

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Molecular mechanism by which palmitate inhibits PKR autophosphorylation.

Cho H, Mukherjee S, Palasuberniam P, Pillow L, Bilgin B, Nezich C, Walton SP, Feig M, Chan C.

Biochemistry. 2011 Feb 15;50(6):1110-9. doi: 10.1021/bi101923r. Epub 2011 Jan 24.

8.

Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR.

Amici C, La Frazia S, Brunelli C, Balsamo M, Angelini M, Santoro MG.

Cell Microbiol. 2015 Sep;17(9):1391-404. doi: 10.1111/cmi.12446. Epub 2015 May 13.

PMID:
25856684
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11.

Translational insensitivity to potent activation of PKR by HCV IRES RNA.

Shimoike T, McKenna SA, Lindhout DA, Puglisi JD.

Antiviral Res. 2009 Sep;83(3):228-37. doi: 10.1016/j.antiviral.2009.05.004. Epub 2009 May 23.

PMID:
19467267
12.

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.

Romano PR, Garcia-Barrio MT, Zhang X, Wang Q, Taylor DR, Zhang F, Herring C, Mathews MB, Qin J, Hinnebusch AG.

Mol Cell Biol. 1998 Apr;18(4):2282-97.

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Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.

Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16894-9. doi: 10.1073/pnas.0805524105. Epub 2008 Oct 29.

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PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking.

Taylor SS, Haste NM, Ghosh G.

Cell. 2005 Sep 23;122(6):823-5. Review.

19.

Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity.

Suganuma T, Swanson SK, Florens L, Washburn MP, Workman JL.

J Mol Cell Biol. 2016 Feb;8(1):44-50. doi: 10.1093/jmcb/mjv070. Epub 2015 Dec 23.

PMID:
26705305
20.

Regulation of de novo translation of host cells by manipulation of PERK/PKR and GADD34-PP1 activity during Newcastle disease virus infection.

Liao Y, Gu F, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C.

J Gen Virol. 2016 Apr;97(4):867-79. doi: 10.1099/jgv.0.000426. Epub 2016 Feb 11.

PMID:
26869028

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