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Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome.

Taltavull N, Muñoz-Cortés M, Lluís L, Jové M, Fortuño A, Molinar-Toribio E, Torres JL, Pazos M, Medina I, Nogués MR.

Lipids Health Dis. 2014 Feb 11;13:31. doi: 10.1186/1476-511X-13-31.


Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome.

Molinar-Toribio E, Pérez-Jiménez J, Ramos-Romero S, Romeu M, Giralt M, Taltavull N, Muñoz-Cortes M, Jáuregui O, Méndez L, Medina I, Torres JL.

Br J Nutr. 2015 Mar 28;113(6):878-87. doi: 10.1017/S0007114514004437. Epub 2015 Feb 27.


Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: Lipidomic biomarkers of oxidative stress and inflammation.

Dasilva G, Pazos M, García-Egido E, Gallardo JM, Rodríguez I, Cela R, Medina I.

J Nutr Biochem. 2015 Nov;26(11):1385-92. doi: 10.1016/j.jnutbio.2015.07.007. Epub 2015 Jul 26.


Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.

Poudyal H, Panchal SK, Ward LC, Brown L.

J Nutr Biochem. 2013 Jun;24(6):1041-52. doi: 10.1016/j.jnutbio.2012.07.014. Epub 2012 Sep 29.


Effect of dietary n-3 fatty acids supplementation on fatty acid metabolism in atorvastatin-administered SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model.

Al Mamun A, Hashimoto M, Katakura M, Tanabe Y, Tsuchikura S, Hossain S, Shido O.

Biomed Pharmacother. 2017 Jan;85:372-379. doi: 10.1016/j.biopha.2016.11.038. Epub 2016 Dec 8.


Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes.

Peterson LD, Thies F, Sanderson P, Newsholme EA, Calder PC.

Life Sci. 1998;62(24):2209-17.


Effects of maternal dietary EPA and DHA supplementation and breeder age on embryonic and post-hatch performance of broiler offspring: age and n-3 pufa affect embryonic and post-hatch performance.

Koppenol A, Delezie E, Wang Y, Franssens L, Willems E, Ampe B, Buyse J, Everaert N.

J Anim Physiol Anim Nutr (Berl). 2015 Apr;99 Suppl S1:36-47. doi: 10.1111/jpn.12308.


Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages.

Koppenol A, Delezie E, Aerts J, Willems E, Wang Y, Franssens L, Everaert N, Buyse J.

Poult Sci. 2014 Mar;93(3):564-73. doi: 10.3382/ps.2013-03320.


Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium.

Khairallah RJ, O'Shea KM, Brown BH, Khanna N, Des Rosiers C, Stanley WC.

J Pharmacol Exp Ther. 2010 Oct;335(1):155-62. doi: 10.1124/jpet.110.170605. Epub 2010 Jul 12.


Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats.

Lluís L, Taltavull N, Muñoz-Cortés M, Sánchez-Martos V, Romeu M, Giralt M, Molinar-Toribio E, Torres JL, Pérez-Jiménez J, Pazos M, Méndez L, Gallardo JM, Medina I, Nogués MR.

Lipids Health Dis. 2013 Oct 1;12:140. doi: 10.1186/1476-511X-12-140.


Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats.

Engström K, Saldeen AS, Yang B, Mehta JL, Saldeen T.

Ups J Med Sci. 2009;114(4):206-13. doi: 10.3109/03009730903268958.


Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition.

Khairallah RJ, Sparagna GC, Khanna N, O'Shea KM, Hecker PA, Kristian T, Fiskum G, Des Rosiers C, Polster BM, Stanley WC.

Biochim Biophys Acta. 2010 Aug;1797(8):1555-62. doi: 10.1016/j.bbabio.2010.05.007. Epub 2010 May 21.


Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice.

Shang T, Liu L, Zhou J, Zhang M, Hu Q, Fang M, Wu Y, Yao P, Gong Z.

Lipids Health Dis. 2017 Mar 29;16(1):65. doi: 10.1186/s12944-017-0461-2.


Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs.

Méndez L, Pazos M, Gallardo JM, Torres JL, Pérez-Jiménez J, Nogués R, Romeu M, Medina I.

Free Radic Biol Med. 2013 Feb;55:8-20. doi: 10.1016/j.freeradbiomed.2012.11.004. Epub 2012 Nov 16.


Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats.

Casey JM, Banz WJ, Krul ES, Butteiger DN, Goldstein DA, Davis JE.

Lipids Health Dis. 2013 Oct 19;12:147. doi: 10.1186/1476-511X-12-147.


Circulating CD36+ microparticles are not altered by docosahexaenoic or eicosapentaenoic acid supplementation.

Phang M, Thorne RF, Alkhatatbeh MJ, Garg ML, Lincz LF.

Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):254-60. doi: 10.1016/j.numecd.2015.12.003. Epub 2015 Dec 18.


The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling.

Shah KB, Duda MK, O'Shea KM, Sparagna GC, Chess DJ, Khairallah RJ, Robillard-Frayne I, Xu W, Murphy RC, Des Rosiers C, Stanley WC.

Hypertension. 2009 Sep;54(3):605-11. doi: 10.1161/HYPERTENSIONAHA.109.135806. Epub 2009 Jul 13.

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