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Items: 1 to 20 of 309

1.

Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation.

Akiyama N, Akiyama Y, Kato H, Kuroda T, Ono T, Imagawa K, Asakura K, Shinosaki T, Murayama T, Hanasaki K.

J Pharmacol Exp Ther. 2014 Apr;349(1):66-74. doi: 10.1124/jpet.113.210716. Epub 2014 Feb 7.

2.

Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice.

Park SB, Jung WH, Kang NS, Park JS, Bae GH, Kim HY, Rhee SD, Kang SK, Ahn JH, Jeong HG, Kim KY.

Eur J Pharmacol. 2013 Dec 5;721(1-3):70-9. doi: 10.1016/j.ejphar.2013.09.052. Epub 2013 Oct 14.

PMID:
24135201
3.
5.

Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice.

Park JS, Rhee SD, Jung WH, Kang NS, Kim HY, Kang SK, Ahn JH, Kim KY.

Eur J Pharmacol. 2012 Sep 15;691(1-3):19-27. doi: 10.1016/j.ejphar.2012.06.024. Epub 2012 Jul 1.

PMID:
22760069
6.

Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1.

Man TY, Michailidou Z, Gokcel A, Ramage L, Chapman KE, Kenyon CJ, Seckl JR, Morton NM.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1076-84. doi: 10.1152/ajpendo.00531.2010. Epub 2011 Mar 15.

7.

11beta-hydroxysteroid dehydrogenase type 1 and obesity.

Morton NM, Seckl JR.

Front Horm Res. 2008;36:146-64. doi: 10.1159/0000115363. Review.

PMID:
18230901
8.

BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice.

Wang L, Liu J, Zhang A, Cheng P, Zhang X, Lv S, Wu L, Yu J, Di W, Zha J, Kong X, Qi H, Zhong Y, Ding G.

PLoS One. 2012;7(7):e40056. doi: 10.1371/journal.pone.0040056. Epub 2012 Jul 2.

9.

Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice.

Véniant MM, Hale C, Komorowski R, Chen MM, St Jean DJ, Fotsch C, Wang M.

Diabetes Obes Metab. 2009 Feb;11(2):109-17. doi: 10.1111/j.1463-1326.2008.00911.x. Epub 2008 May 12.

PMID:
18479468
10.

HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.

Okazaki S, Takahashi T, Iwamura T, Nakaki J, Sekiya Y, Yagi M, Kumagai H, Sato M, Sakami S, Nitta A, Kawai K, Kainoh M.

J Pharmacol Exp Ther. 2014 Oct;351(1):181-9. doi: 10.1124/jpet.114.216556. Epub 2014 Aug 6.

11.
12.
13.

Cortisone induces insulin resistance in C2C12 myotubes through activation of 11beta-hydroxysteroid dehydrogenase 1 and autocrinal regulation.

Park SY, Bae JH, Cho YS.

Cell Biochem Funct. 2014 Apr;32(3):249-57. doi: 10.1002/cbf.3008. Epub 2013 Oct 7.

PMID:
24122936
14.

Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity.

Liu J, Wang L, Zhang A, Di W, Zhang X, Wu L, Yu J, Zha J, Lv S, Cheng P, Hu M, Li Y, Qi H, Ding G, Zhong Y.

Endocr J. 2011;58(3):199-209. Epub 2011 Feb 17.

15.

11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.

Pereira CD, Azevedo I, Monteiro R, Martins MJ.

Diabetes Obes Metab. 2012 Oct;14(10):869-81. doi: 10.1111/j.1463-1326.2012.01582.x. Epub 2012 Mar 8. Review.

PMID:
22321826
16.

Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats.

Sieber-Ruckstuhl NS, Zini E, Osto M, Franchini M, Boretti FS, Meli ML, Sigrist B, Lutz TA, Reusch CE.

Domest Anim Endocrinol. 2010 Nov;39(4):222-30. doi: 10.1016/j.domaniend.2010.06.003. Epub 2010 Jul 14.

PMID:
20688460
17.

A novel 11β-HSD1 inhibitor improves diabesity and osteoblast differentiation.

Park JS, Bae SJ, Choi SW, Son YH, Park SB, Rhee SD, Kim HY, Jung WH, Kang SK, Ahn JH, Kim SH, Kim KY.

J Mol Endocrinol. 2014 Mar 6;52(2):191-202. doi: 10.1530/JME-13-0177. Print 2014 Apr.

PMID:
24444497
18.

Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.

Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y.

Br J Pharmacol. 2010 Sep;161(1):113-26. doi: 10.1111/j.1476-5381.2010.00826.x.

19.

Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue.

Apostolova G, Schweizer RA, Balazs Z, Kostadinova RM, Odermatt A.

Am J Physiol Endocrinol Metab. 2005 May;288(5):E957-64. Epub 2004 Dec 21.

20.

11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue.

Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y.

Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E84-95. doi: 10.1152/ajpendo.00205.2014. Epub 2014 Nov 11.

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