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Items: 1 to 20 of 145

1.

Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects.

Al-Jenoobi FI, Al-Thukair AA, Alam MA, Abbas FA, Al-Mohizea AM, Alkharfy KM, Al-Suwayeh SA.

Eur J Drug Metab Pharmacokinet. 2015 Mar;40(1):61-6. doi: 10.1007/s13318-014-0180-2. Epub 2014 Feb 9.

PMID:
24510399
2.

Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.

Al-Jenoobi FI, Al-Thukair AA, Abbas FA, Ansari MJ, Alkharfy KM, Al-Mohizea AM, Al-Suwayeh SA, Jamil S.

Drug Metab Lett. 2010 Jan;4(1):51-5.

PMID:
20201775
3.

Effect of Trigonella foenum-graecum L. on Metabolic Activity of CYP2D6 and CYP3A4.

Al-Jenoobi FI, Al-Thukair AA, Alam MA, Abbas FA, Al-Mohizea AM, Alkharfy KM, Al-Suwayeh SA.

Forsch Komplementmed. 2015;22(3):180-4. doi: 10.1159/000432412. Epub 2015 Jun 22.

PMID:
26335391
4.

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.

von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI.

J Pharm Pharmacol. 1998 Sep;50(9):997-1004.

PMID:
9811160
5.

Effect of Garden Cress Seeds Powder and Its Alcoholic Extract on the Metabolic Activity of CYP2D6 and CYP3A4.

Al-Jenoobi FI, Al-Thukair AA, Alam MA, Abbas FA, Al-Mohizea AM, Alkharfy KM, Al-Suwayeh SA.

Evid Based Complement Alternat Med. 2014;2014:634592. doi: 10.1155/2014/634592. Epub 2014 Mar 10.

6.

Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans.

Yubero-Lahoz S, Pardo R, Farré M, O'Mahony B, Torrens M, Mustata C, Pérez-Mañá C, Carbó ML, de la Torre R.

Clin Pharmacokinet. 2011 May;50(5):319-29. doi: 10.2165/11584550-000000000-00000.

PMID:
21456632
7.

Investigation of CYP3A4 and CYP2D6 Interactions of Withania somnifera and Centella asiatica in Human Liver Microsomes.

Savai J, Varghese A, Pandita N, Chintamaneni M.

Phytother Res. 2015 May;29(5):785-90. doi: 10.1002/ptr.5308. Epub 2015 Feb 13.

PMID:
25684704
8.

In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.

Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE.

J Ethnopharmacol. 2010 Jul 20;130(2):275-83. doi: 10.1016/j.jep.2010.05.002. Epub 2010 May 8.

PMID:
20457244
9.

Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin.

Al-Jenoobi FI, Al-Thukair AA, Alam MA, Abbas FA, Al-Mohizea AM, Alkharfy KM, Al-Suwayeh SA.

Saudi Pharm J. 2014 Dec;22(6):564-9. doi: 10.1016/j.jsps.2014.03.004. Epub 2014 Apr 3.

10.

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

Schmider J, Greenblatt DJ, Fogelman SM, von Moltke LL, Shader RI.

Biopharm Drug Dispos. 1997 Apr;18(3):227-40.

PMID:
9113345
12.

Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.

Jones DR, Gorski JC, Haehner BD, O'Mara EM Jr, Hall SD.

Clin Pharmacol Ther. 1996 Oct;60(4):374-84.

PMID:
8873685
13.

The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.

Bedada W, de Andrés F, Engidawork E, Pohanka A, Beck O, Bertilsson L, Llerena A, Aklillu E.

J Clin Psychopharmacol. 2015 Dec;35(6):694-9. doi: 10.1097/JCP.0000000000000413.

PMID:
26444948
14.

Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity.

Ye LH, Kong LT, Yan MZ, Cao FR, Wang LS, Liao YH, Pan RL, Chang Q.

J Ethnopharmacol. 2016 Dec 24;194:913-917. doi: 10.1016/j.jep.2016.10.055. Epub 2016 Oct 19.

PMID:
27771456
16.

Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes.

Han SY, Zhao HY, Zhou N, Zhou F, Li PP.

J Ethnopharmacol. 2014;151(1):210-7. doi: 10.1016/j.jep.2013.10.021. Epub 2013 Oct 21.

PMID:
24157377
17.

Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.

Van LM, Sarda S, Hargreaves JA, Rostami-Hodjegan A.

J Pharm Sci. 2009 Feb;98(2):763-71. doi: 10.1002/jps.21455.

PMID:
18543297
18.

Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice.

Jurica J, Bartecek R, Zourkova A, Pindurova E, Sulcova A, Kasparek T, Zendulka O.

J Clin Pharm Ther. 2012 Aug;37(4):486-90. doi: 10.1111/j.1365-2710.2012.01333.x. Epub 2012 May 1.

PMID:
22548589
19.
20.

In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.

Weiss J, Sawa E, Riedel KD, Haefeli WE, Mikus G.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Sep;378(3):275-82. doi: 10.1007/s00210-008-0294-7. Epub 2008 May 31.

PMID:
18516595

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