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Items: 1 to 20 of 194

1.

Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins.

Chen P, Zeng H, Wang Y, Fan X, Xu C, Deng R, Zhou X, Bi H, Huang M.

Drug Metab Dispos. 2014 May;42(5):844-52. doi: 10.1124/dmd.113.056549. Epub 2014 Feb 7.

2.

Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.

Chen P, Li J, Fan X, Zeng H, Deng R, Li D, Huang M, Bi H.

Eur J Pharmacol. 2015 Oct 15;765:131-9. doi: 10.1016/j.ejphar.2015.08.029. Epub 2015 Aug 20.

PMID:
26297978
3.

Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.

Liu J, Lu YF, Zhang Y, Wu KC, Fan F, Klaassen CD.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):816-24. doi: 10.1016/j.taap.2013.08.003. Epub 2013 Aug 13.

4.

Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.

Zeng H, Li D, Qin X, Chen P, Tan H, Zeng X, Li X, Fan X, Jiang Y, Zhou Y, Chen Y, Wang Y, Huang M, Bi H.

Drug Metab Dispos. 2016 Mar;44(3):337-42. doi: 10.1124/dmd.115.066969. Epub 2015 Dec 10.

5.

Protective Effects of Alisol B 23-Acetate Via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Estrogen-Induced Cholestatic Liver Injury in Mice.

Meng Q, Chen X, Wang C, Liu Q, Sun H, Sun P, Huo X, Liu Z, Yao J, Liu K.

Pharm Res. 2015 Nov;32(11):3688-98. doi: 10.1007/s11095-015-1727-x. Epub 2015 Jun 4.

PMID:
26040663
6.

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD.

Toxicol Sci. 2009 Jul;110(1):47-60. doi: 10.1093/toxsci/kfp094. Epub 2009 Apr 30.

7.

Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.

Meng Q, Chen XL, Wang CY, Liu Q, Sun HJ, Sun PY, Huo XK, Liu ZH, Yao JH, Liu KX.

Toxicol Appl Pharmacol. 2015 Mar 15;283(3):178-86. doi: 10.1016/j.taap.2015.01.020. Epub 2015 Feb 3.

PMID:
25655198
8.

Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.

Teng S, Piquette-Miller M.

Br J Pharmacol. 2007 Jun;151(3):367-76. Epub 2007 Apr 16.

9.

Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.

Kitada H, Miyata M, Nakamura T, Tozawa A, Honma W, Shimada M, Nagata K, Sinal CJ, Guo GL, Gonzalez FJ, Yamazoe Y.

J Biol Chem. 2003 May 16;278(20):17838-44. Epub 2003 Mar 7.

10.

Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis.

Muchova L, Vanova K, Suk J, Micuda S, Dolezelova E, Fuksa L, Cerny D, Farghali H, Zelenkova M, Lenicek M, Wong RJ, Vreman HJ, Vitek L.

J Cell Mol Med. 2015 May;19(5):924-33. doi: 10.1111/jcmm.12401. Epub 2015 Feb 16.

11.

Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL.

Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G925-36. doi: 10.1152/ajpgi.00263.2011. Epub 2012 Feb 16.

12.

Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.

Beilke LD, Besselsen DG, Cheng Q, Kulkarni S, Slitt AL, Cherrington NJ.

Toxicol Sci. 2008 Mar;102(1):196-204. Epub 2007 Nov 20.

PMID:
18032408
13.

Glutamine attenuates obstructive cholestasis in rats via farnesoid X receptor-mediated regulation of Bsep and Mrp2.

Liu B, Li Y, Ji H, Lu H, Li H, Shi Y.

Can J Physiol Pharmacol. 2017 Feb;95(2):215-223. doi: 10.1139/cjpp-2016-0389. Epub 2016 Oct 5.

PMID:
28051334
14.

Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury.

Wang YG, Zhou JM, Ma ZC, Li H, Liang QD, Tan HL, Xiao CR, Zhang BL, Gao Y.

Chem Biol Interact. 2012 Oct 25;200(1):11-20. doi: 10.1016/j.cbi.2012.08.023. Epub 2012 Sep 13.

PMID:
22982774
15.

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G126-35. doi: 10.1152/ajpgi.00522.2010. Epub 2010 Apr 15.

16.

Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD.

Toxicol Sci. 2008 Dec;106(2):319-28. doi: 10.1093/toxsci/kfn177. Epub 2008 Aug 29.

17.

Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.

Chen H, Huang X, Min J, Li W, Zhang R, Zhao W, Liu C, Yi L, Mi S, Wang N, Wang Q, Zhu C.

J Ethnopharmacol. 2016 Feb 17;179:197-207. doi: 10.1016/j.jep.2015.12.033. Epub 2015 Dec 23.

PMID:
26723467
18.

Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARĪ±-, and Nrf2-null mice.

Aleksunes LM, Klaassen CD.

Drug Metab Dispos. 2012 Jul;40(7):1366-79. doi: 10.1124/dmd.112.045112. Epub 2012 Apr 11.

19.

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K, Jaeschke H, Denk H, Trauner M.

Am J Pathol. 2006 Feb;168(2):410-22.

20.

ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.

Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD.

Toxicol Sci. 2009 Apr;108(2):247-57. doi: 10.1093/toxsci/kfp020. Epub 2009 Jan 29.

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