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Items: 1 to 20 of 105

1.

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S.

Neuron. 2014 Mar 5;81(5):1001-8. doi: 10.1016/j.neuron.2014.01.011. Epub 2014 Feb 6.

2.

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.

3.

Motor neuron death in ALS: programmed by astrocytes?

Pirooznia SK, Dawson VL, Dawson TM.

Neuron. 2014 Mar 5;81(5):961-3. doi: 10.1016/j.neuron.2014.02.024.

4.

Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death.

Ranno E, D'Antoni S, Spatuzza M, Berretta A, Laureanti F, Bonaccorso CM, Pellitteri R, Longone P, Spalloni A, Iyer AM, Aronica E, Catania MV.

Neurobiol Dis. 2014 May;65:160-71. doi: 10.1016/j.nbd.2014.01.002. Epub 2014 Jan 11.

PMID:
24423643
5.

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.

Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK.

Neuron. 2014 Mar 5;81(5):1009-23. doi: 10.1016/j.neuron.2014.01.013.

6.

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.

7.

Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.

Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.

Stem Cells Transl Med. 2012 May;1(5):396-402. doi: 10.5966/sctm.2011-0061. Epub 2012 May 8.

8.

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T.

Ann Neurol. 2010 Jun;67(6):739-48. doi: 10.1002/ana.22051.

9.

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.

Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J, Shaw PJ.

Brain. 2011 Sep;134(Pt 9):2627-41. doi: 10.1093/brain/awr193.

10.

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22. Epub 2007 Apr 15.

11.

Altered astrocytic expression of TDP-43 does not influence motor neuron survival.

Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ.

Exp Neurol. 2013 Dec;250:250-9. doi: 10.1016/j.expneurol.2013.10.004. Epub 2013 Oct 9.

PMID:
24120466
12.

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.

Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):829-32. doi: 10.1073/pnas.1314085111. Epub 2013 Dec 30.

13.

Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.

Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN.

J Neurosci. 2014 Nov 19;34(47):15587-600. doi: 10.1523/JNEUROSCI.2037-14.2014.

14.

Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models.

Kato S, Kato M, Abe Y, Matsumura T, Nishino T, Aoki M, Itoyama Y, Asayama K, Awaya A, Hirano A, Ohama E.

Acta Neuropathol. 2005 Aug;110(2):101-12. Epub 2005 Jun 28.

PMID:
15983830
15.

S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients.

Hoyaux D, Boom A, Van den Bosch L, Belot N, Martin JJ, Heizmann CW, Kiss R, Pochet R.

J Neuropathol Exp Neurol. 2002 Aug;61(8):736-44.

16.

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis.

Gandelman M, Peluffo H, Beckman JS, Cassina P, Barbeito L.

J Neuroinflammation. 2010 Jun 9;7:33. doi: 10.1186/1742-2094-7-33.

17.

Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1(G93A) mouse model.

Lilo E, Wald-Altman S, Solmesky LJ, Ben Yaakov K, Gershoni-Emek N, Bulvik S, Kassis I, Karussis D, Perlson E, Weil M.

Hum Mol Genet. 2013 Dec 1;22(23):4720-5. doi: 10.1093/hmg/ddt325. Epub 2013 Jul 7.

18.

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Song S, Miranda CJ, Braun L, Meyer K, Frakes AE, Ferraiuolo L, Likhite S, Bevan AK, Foust KD, McConnell MJ, Walker CM, Kaspar BK.

Nat Med. 2016 Apr;22(4):397-403. doi: 10.1038/nm.4052. Epub 2016 Feb 29.

19.

Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS.

Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P.

Integr Biol (Camb). 2013 Jul 24;5(7):964-75. doi: 10.1039/c3ib40022k. Epub 2013 May 22.

PMID:
23695230
20.

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN.

PLoS One. 2007 Aug 1;2(8):e689.

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