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Items: 1 to 20 of 103

1.

Decoding the structural events in substrate-gating mechanism of eukaryotic prolyl oligopeptidase using normal mode analysis and molecular dynamics simulations.

Kaushik S, Etchebest C, Sowdhamini R.

Proteins. 2014 Jul;82(7):1428-43. doi: 10.1002/prot.24511. Epub 2014 Feb 6.

PMID:
24500901
2.

Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase.

Kaszuba K, Róg T, Danne R, Canning P, Fülöp V, Juhász T, Szeltner Z, St Pierre JF, García-Horsman A, Männistö PT, Karttunen M, Hokkanen J, Bunker A.

Biochimie. 2012 Jun;94(6):1398-411. doi: 10.1016/j.biochi.2012.03.012. Epub 2012 Mar 30.

PMID:
22484394
3.

Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.

Kaushik S, Sowdhamini R.

PLoS One. 2011;6(11):e26251. doi: 10.1371/journal.pone.0026251. Epub 2011 Nov 23.

4.

Prolyl oligopeptidase structure and dynamics.

Rea D, Fülöp V.

CNS Neurol Disord Drug Targets. 2011 May;10(3):306-10. Review.

PMID:
21222626
5.

Computational Analysis of the Domain Architecture and Substrate-Gating Mechanism of Prolyl Oligopeptidases from Shewanella woodyi and Identification of Probable Lead Molecules.

Patil P, Skariyachan S, Mutt E, Kaushik S.

Interdiscip Sci. 2016 Sep;8(3):284-93. doi: 10.1007/s12539-015-0282-9. Epub 2015 Aug 23.

PMID:
26298583
6.

Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.

Bastos IM, Grellier P, Martins NF, Cadavid-Restrepo G, de Souza-Ault MR, Augustyns K, Teixeira AR, Schrével J, Maigret B, da Silveira JF, Santana JM.

Biochem J. 2005 May 15;388(Pt 1):29-38.

7.

Structure, function and biological relevance of prolyl oligopeptidase.

Szeltner Z, Polgár L.

Curr Protein Pept Sci. 2008 Feb;9(1):96-107. Review.

PMID:
18336325
8.

The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity.

Szeltner Z, Juhász T, Szamosi I, Rea D, Fülöp V, Módos K, Juliano L, Polgár L.

Biochim Biophys Acta. 2013 Jan;1834(1):98-111. doi: 10.1016/j.bbapap.2012.08.012. Epub 2012 Aug 19.

PMID:
22940581
9.

Evolutionary relationships of the prolyl oligopeptidase family enzymes.

Venäläinen JI, Juvonen RO, Männistö PT.

Eur J Biochem. 2004 Jul;271(13):2705-15.

10.

Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways.

Fuxreiter M, Magyar C, Juhász T, Szeltner Z, Polgár L, Simon I.

Proteins. 2005 Aug 15;60(3):504-12.

PMID:
15971204
11.

Kinetic and mechanistic studies of prolyl oligopeptidase from the hyperthermophile Pyrococcus furiosus.

Harris MN, Madura JD, Ming LJ, Harwood VJ.

J Biol Chem. 2001 Jun 1;276(22):19310-7. Epub 2001 Feb 20.

12.

Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics.

López A, Herranz-Trillo F, Kotev M, Gairí M, Guallar V, Bernadó P, Millet O, Tarragó T, Giralt E.

Chembiochem. 2016 May 17;17(10):913-7. doi: 10.1002/cbic.201600102. Epub 2016 Mar 30.

PMID:
26918396
13.

Induced-fit mechanism for prolyl endopeptidase.

Li M, Chen C, Davies DR, Chiu TK.

J Biol Chem. 2010 Jul 9;285(28):21487-95. doi: 10.1074/jbc.M109.092692. Epub 2010 May 5.

14.

Mechanisms of intramolecular communication in a hyperthermophilic acylaminoacyl peptidase: a molecular dynamics investigation.

Papaleo E, Renzetti G, Tiberti M.

PLoS One. 2012;7(4):e35686. doi: 10.1371/journal.pone.0035686. Epub 2012 Apr 27.

15.

Structure and function relationship in prolyl oligopeptidase.

Van Elzen R, Lambeir AM.

CNS Neurol Disord Drug Targets. 2011 May;10(3):297-305. Review.

PMID:
21222621
16.

Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding.

Szeltner Z, Rea D, Juhász T, Renner V, Fülöp V, Polgár L.

J Mol Biol. 2004 Jul 9;340(3):627-37.

PMID:
15210359
17.

Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2.

Chaganti LK, Kuppili RR, Bose K.

FASEB J. 2013 Aug;27(8):3054-66. doi: 10.1096/fj.13-227256. Epub 2013 Apr 22.

18.

A new side opening on prolyl oligopeptidase revealed by electron microscopy.

Tarragó T, Martín-Benito J, Sabidó E, Claasen B, Madurga S, Gairí M, Valpuesta JM, Giralt E.

FEBS Lett. 2009 Oct 20;583(20):3344-8. doi: 10.1016/j.febslet.2009.09.036. Epub 2009 Sep 25.

19.

The prolyl oligopeptidase family.

Polgár L.

Cell Mol Life Sci. 2002 Feb;59(2):349-62. Review.

PMID:
11915948
20.

Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity.

Shan L, Mathews II, Khosla C.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3599-604. Epub 2005 Feb 28.

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