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Items: 1 to 20 of 142

1.

A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.

Brooks AN, Choi PS, de Waal L, Sharifnia T, Imielinski M, Saksena G, Pedamallu CS, Sivachenko A, Rosenberg M, Chmielecki J, Lawrence MS, DeLuca DS, Getz G, Meyerson M.

PLoS One. 2014 Jan 31;9(1):e87361. doi: 10.1371/journal.pone.0087361. eCollection 2014.

2.

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.

Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J, Ndonwi M, Wadugu B, Duncavage EJ, Okeyo-Owuor T, Liu T, Griffith M, McGrath S, Magrini V, Fulton RS, Fronick C, O'Laughlin M, Graubert TA, Walter MJ.

Cancer Cell. 2015 May 11;27(5):631-43. doi: 10.1016/j.ccell.2015.04.008.

3.

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

Fei DL, Motowski H, Chatrikhi R, Prasad S, Yu J, Gao S, Kielkopf CL, Bradley RK, Varmus H.

PLoS Genet. 2016 Oct 24;12(10):e1006384. doi: 10.1371/journal.pgen.1006384. eCollection 2016 Oct.

4.

U2AF1 mutations alter splice site recognition in hematological malignancies.

Ilagan JO, Ramakrishnan A, Hayes B, Murphy ME, Zebari AS, Bradley P, Bradley RK.

Genome Res. 2015 Jan;25(1):14-26. doi: 10.1101/gr.181016.114. Epub 2014 Sep 29.

5.

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms.

Przychodzen B, Jerez A, Guinta K, Sekeres MA, Padgett R, Maciejewski JP, Makishima H.

Blood. 2013 Aug 8;122(6):999-1006. doi: 10.1182/blood-2013-01-480970. Epub 2013 Jun 17.

6.

Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors.

Je EM, Yoo NJ, Kim YJ, Kim MS, Lee SH.

Int J Cancer. 2013 Jul;133(1):260-5. doi: 10.1002/ijc.28011. Epub 2013 Feb 5.

7.

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.

Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA.

Leukemia. 2015 Apr;29(4):909-17. doi: 10.1038/leu.2014.303. Epub 2014 Oct 14.

8.

Alteration of the SETBP1 gene and splicing pathway genes SF3B1, U2AF1, and SRSF2 in childhood acute myeloid leukemia.

Choi HW, Kim HR, Baek HJ, Kook H, Cho D, Shin JH, Suh SP, Ryang DW, Shin MG.

Ann Lab Med. 2015 Jan;35(1):118-22. doi: 10.3343/alm.2015.35.1.118. Epub 2014 Dec 8.

9.

Splicing Factor Mutations in Cancer.

Bejar R.

Adv Exp Med Biol. 2016;907:215-28. doi: 10.1007/978-3-319-29073-7_9.

PMID:
27256388
10.

Splicing factor mutations and cancer.

Yoshida K, Ogawa S.

Wiley Interdiscip Rev RNA. 2014 Jul-Aug;5(4):445-59. doi: 10.1002/wrna.1222. Epub 2014 Feb 12. Review.

11.

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Grillot M, Baty J, Heath S, Frater JL, Nasim T, Link DC, Tomasson MH, Westervelt P, DiPersio JF, Mardis ER, Ley TJ, Wilson RK, Walter MJ.

Nat Genet. 2011 Dec 11;44(1):53-7. doi: 10.1038/ng.1031.

12.

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis.

Makishima H, Visconte V, Sakaguchi H, Jankowska AM, Abu Kar S, Jerez A, Przychodzen B, Bupathi M, Guinta K, Afable MG, Sekeres MA, Padgett RA, Tiu RV, Maciejewski JP.

Blood. 2012 Apr 5;119(14):3203-10. doi: 10.1182/blood-2011-12-399774. Epub 2012 Feb 9.

13.

U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

Qian J, Yao DM, Lin J, Qian W, Wang CZ, Chai HY, Yang J, Li Y, Deng ZQ, Ma JC, Chen XX.

PLoS One. 2012;7(9):e45760. doi: 10.1371/journal.pone.0045760. Epub 2012 Sep 19.

14.

Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.

Pacheco TR, Gomes AQ, Barbosa-Morais NL, Benes V, Ansorge W, Wollerton M, Smith CW, Valcárcel J, Carmo-Fonseca M.

J Biol Chem. 2004 Jun 25;279(26):27039-49. Epub 2004 Apr 19.

15.

Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.

Hong JY, Seo JY, Kim SH, Jung HA, Park S, Kim K, Jung CW, Kim JS, Park JS, Kim HJ, Jang JH.

Anticancer Res. 2015 May;35(5):3081-9.

PMID:
25964599
16.

Frequent pathway mutations of splicing machinery in myelodysplasia.

Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.

Nature. 2011 Sep 11;478(7367):64-9. doi: 10.1038/nature10496.

PMID:
21909114
17.

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3' splice-site organization and activity of U2AF-related proteins.

Kralovicova J, Knut M, Cross NC, Vorechovsky I.

Nucleic Acids Res. 2015 Apr 20;43(7):3747-63. doi: 10.1093/nar/gkv194. Epub 2015 Mar 16.

18.

Impact of allogeneic hematopoietic cell transplant in patients with myeloid neoplasms carrying spliceosomal mutations.

Hamilton BK, Visconte V, Jia X, Tabarroki A, Makishima H, Hasrouni E, Abounader D, Kalaycio M, Sekeres MA, Sobecks R, Duong Liu H, Bolwell B, Maciejewski JP, Copelan E, Tiu RV.

Am J Hematol. 2016 Jun;91(4):406-9. doi: 10.1002/ajh.24306. Epub 2016 Mar 14.

19.

The prognostic impact of mutations in spliceosomal genes for myelodysplastic syndrome patients without ring sideroblasts.

Kang MG, Kim HR, Seo BY, Lee JH, Choi SY, Kim SH, Shin JH, Suh SP, Ahn JS, Shin MG.

BMC Cancer. 2015 Jun 27;15:484. doi: 10.1186/s12885-015-1493-5.

20.

Allele-specific recognition of the 3' splice site of INS intron 1.

Kralovicova J, Vorechovsky I.

Hum Genet. 2010 Oct;128(4):383-400. doi: 10.1007/s00439-010-0860-1. Epub 2010 Jul 14.

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