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Items: 1 to 20 of 115


Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells.

Hensley PJ, Desiniotis A, Wang C, Stromberg A, Chen CS, Kyprianou N.

PLoS One. 2014 Jan 31;9(1):e86238. doi: 10.1371/journal.pone.0086238. eCollection 2014.


Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and β1 integrin activation.

Lee HA, Park I, Byun HJ, Jeoung D, Kim YM, Lee H.

Cell Physiol Biochem. 2011;27(5):575-86. doi: 10.1159/000329979. Epub 2011 Jun 15.


Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma.

Sakamoto S, Schwarze S, Kyprianou N.

Eur Urol. 2011 May;59(5):734-44. doi: 10.1016/j.eururo.2010.12.038. Epub 2011 Jan 12.


Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines.

Kacsinta AD, Rubenstein CS, Sroka IC, Pawar S, Gard JM, Nagle RB, Cress AE.

Biochem Biophys Res Commun. 2014 Nov 14;454(2):335-40. doi: 10.1016/j.bbrc.2014.10.073. Epub 2014 Oct 22.


Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance.

Sakamoto S, McCann RO, Dhir R, Kyprianou N.

Cancer Res. 2010 Mar 1;70(5):1885-95. doi: 10.1158/0008-5472.CAN-09-2833. Epub 2010 Feb 16.


Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity.

Garrison JB, Shaw YJ, Chen CS, Kyprianou N.

Cancer Res. 2007 Dec 1;67(23):11344-52.


Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.

Jin JK, Tien PC, Cheng CJ, Song JH, Huang C, Lin SH, Gallick GE.

Oncogene. 2015 Apr 2;34(14):1811-21. doi: 10.1038/onc.2014.116. Epub 2014 May 5.


Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.

Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1170-8. doi: 10.1016/j.bbamcr.2016.02.015. Epub 2016 Feb 24.


Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis.

Tahmatzopoulos A, Sheng S, Kyprianou N.

Oncogene. 2005 Aug 11;24(34):5375-83.


Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

Wangpu X, Lu J, Xi R, Yue F, Sahni S, Park KC, Menezes S, Huang ML, Zheng M, Kovacevic Z, Richardson DR.

Mol Pharmacol. 2016 May;89(5):521-40. doi: 10.1124/mol.115.103044. Epub 2016 Feb 19.


ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.

Schlienger S, Ramirez RA, Claing A.

Cell Signal. 2015 Mar;27(3):403-15. doi: 10.1016/j.cellsig.2014.11.032. Epub 2014 Dec 19.


Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin.

Zhang H, Chen Y, Wadham C, McCaughan GW, Keane FM, Gorrell MD.

Biochim Biophys Acta. 2015 Feb;1853(2):470-80. doi: 10.1016/j.bbamcr.2014.11.029. Epub 2014 Dec 5.


HGF and the regulation of tight junctions in human prostate cancer cells.

Martin TA, Mason MD, Jiang WG.

Oncol Rep. 2014 Jul;32(1):213-24. doi: 10.3892/or.2014.3219. Epub 2014 May 26.


Targeting anoikis resistance in prostate cancer metastasis.

Sakamoto S, Kyprianou N.

Mol Aspects Med. 2010 Apr;31(2):205-14. doi: 10.1016/j.mam.2010.02.001. Epub 2010 Feb 11. Review.


Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation.

Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR, López-Barahona M.

Int J Oncol. 2005 Dec;27(6):1617-23.


Significance of talin in cancer progression and metastasis.

Desiniotis A, Kyprianou N.

Int Rev Cell Mol Biol. 2011;289:117-47. doi: 10.1016/B978-0-12-386039-2.00004-3. Review.

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