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Sos1 regulates sustained TCR-mediated Erk activation.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.

Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.


Deconstructing Ras signaling in the thymus.

Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.

Mol Cell Biol. 2012 Jul;32(14):2748-59. doi: 10.1128/MCB.00317-12. Epub 2012 May 14.


TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.

Warnecke N, Poltorak M, Kowtharapu BS, Arndt B, Stone JC, Schraven B, Simeoni L.

EMBO Rep. 2012 Apr;13(4):386-91. doi: 10.1038/embor.2012.17.


Targeted Sos1 deletion reveals its critical role in early T-cell development.

Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12. doi: 10.1073/pnas.1104295108. Epub 2011 Jul 11.


Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.

Mol Cell Biol. 2007 Apr;27(7):2732-45. Epub 2007 Feb 5.


Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL.

J Biol Chem. 2004 Apr 30;279(18):18239-46. Epub 2004 Feb 5.


Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.

Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW.

J Immunol. 2013 Mar 1;190(5):1927-35. doi: 10.4049/jimmunol.1200653. Epub 2013 Jan 28.


Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice.

Chen X, Priatel JJ, Chow MT, Teh HS.

J Immunol. 2008 May 1;180(9):5973-82.


Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.

Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.


Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.

Eur J Immunol. 2015 Aug;45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5.


Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.

Kortum RL, Rouquette-Jazdanian AK, Samelson LE.

Trends Immunol. 2013 Jun;34(6):259-68. doi: 10.1016/ Epub 2013 Mar 15. Review.


A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.

Mol Cell Biol. 2005 Jun;25(11):4426-41.


IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens.

Deshpande P, Cavanagh MM, Le Saux S, Singh K, Weyand CM, Goronzy JJ.

J Immunol. 2013 Feb 15;190(4):1416-23. doi: 10.4049/jimmunol.1201620. Epub 2013 Jan 16.


Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.

Kwan DH, Yung LY, Ye RD, Wong YH.

J Cell Biochem. 2012 Nov;113(11):3486-97. doi: 10.1002/jcb.24225.


The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.


RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

Priatel JJ, Chen X, Dhanji S, Abraham N, Teh HS.

J Immunol. 2006 Aug 1;177(3):1470-80.


The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.

Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E.

EMBO J. 2000 Feb 15;19(4):642-54.


Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.

Schneider H, Wang H, Raab M, Valk E, Smith X, Lovatt M, Wu Z, Maqueira-Iglesias B, Strebhardt K, Rudd CE.

PLoS One. 2008 Mar 5;3(3):e1718. doi: 10.1371/journal.pone.0001718.


Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.

Mol Cell Biol. 2013 Nov;33(22):4562-78. doi: 10.1128/MCB.01026-13. Epub 2013 Sep 16.

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