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Items: 1 to 20 of 106

1.

In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.

Hakonen E, Ustinov J, Eizirik DL, Sariola H, Miettinen PJ, Otonkoski T.

Diabetologia. 2014 May;57(5):970-9. doi: 10.1007/s00125-014-3175-2. Epub 2014 Feb 4.

PMID:
24493201
2.

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway.

Li Z, Shangguan Z, Liu Y, Wang J, Li X, Yang S, Liu S.

J Mol Endocrinol. 2014 Aug;53(1):71-9. doi: 10.1530/JME-13-0302. Epub 2014 May 14.

PMID:
24827001
3.

Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis.

González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A.

Endocrinology. 2010 Apr;151(4):1487-98. doi: 10.1210/en.2009-0975. Epub 2010 Feb 22.

4.

Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

Gastroenterology. 2008 Mar;134(3):727-37. doi: 10.1053/j.gastro.2007.12.033. Epub 2008 Feb 1.

5.

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.

Venieratos PD, Drossopoulou GI, Kapodistria KD, Tsilibary EC, Kitsiou PV.

Cell Signal. 2010 May;22(5):791-800. doi: 10.1016/j.cellsig.2010.01.003. Epub 2010 Jan 11.

PMID:
20067833
6.

Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice.

Wang X, Liu Y, Yang Z, Zhang Z, Zhou W, Ye Z, Zhang W, Zhang S, Yang Z, Feng X, Chen F, Hu R.

Diabetologia. 2011 Apr;54(4):852-63. doi: 10.1007/s00125-011-2048-1. Epub 2011 Jan 26.

PMID:
21267538
7.

Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Raufman JP, Shant J, Guo CY, Roy S, Cheng K.

J Cell Physiol. 2008 May;215(2):538-49.

8.

The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.

Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

Diabetes. 2006 Jun;55(6):1614-24.

9.

Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivo.

Bone RN, Icyuz M, Zhang Y, Zhang Y, Cui W, Wang H, Peng JB, Matthews QL, Siegal GP, Wu H.

Islets. 2012 Nov-Dec;4(6):366-78. doi: 10.4161/isl.22721. Epub 2012 Nov 1.

10.

EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells.

Martínez-Palacián A, del Castillo G, Herrera B, Fernández M, Roncero C, Fabregat I, Sánchez A.

Cell Signal. 2012 Feb;24(2):505-13. doi: 10.1016/j.cellsig.2011.09.031. Epub 2011 Oct 7.

PMID:
22001397
11.

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27.

13.
14.

Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling.

Kapodistria K, Tsilibary EP, Politis P, Moustardas P, Charonis A, Kitsiou P.

Mol Cell Endocrinol. 2015 Jan 15;400:112-28. doi: 10.1016/j.mce.2014.11.003. Epub 2014 Nov 28.

15.

Increased perinatal remodelling of the pancreas in somatostatin-deficient mice: potential role of transforming growth factor-beta signalling in regulating beta cell growth in early life.

Richardson CC, To K, Foot VL, Hauge-Evans AC, Carmignac D, Christie MR.

Horm Metab Res. 2015 Jan;47(1):56-63. doi: 10.1055/s-0034-1390427. Epub 2014 Oct 28.

PMID:
25350519
16.

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation.

Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori RL.

Diabetologia. 2008 Feb;51(2):298-308. Epub 2007 Dec 8.

PMID:
18066521
17.

Selective expansion of the beta-cell compartment in the pancreas of keratinocyte growth factor transgenic mice.

Wagner M, Koschnick S, Beilke S, Frey M, Adler G, Schmid RM.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1139-47. doi: 10.1152/ajpgi.00338.2007. Epub 2008 Mar 27.

18.

Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

Ruiz-Martínez A, Vázquez-Juárez E, Ramos-Mandujano G, Pasantes-Morales H.

Biosci Rep. 2011 Dec;31(6):489-97. doi: 10.1042/BSR20110024.

PMID:
21568938
19.

Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM Jr, Cover TL, Washington MK, Wilson KT, Polk DB.

Gastroenterology. 2009 Apr;136(4):1297-1307, e1-3. doi: 10.1053/j.gastro.2008.12.059. Epub 2009 Jan 1.

20.

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. doi: 10.2337/db07-1469. Epub 2008 Feb 14.

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