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Items: 1 to 20 of 99

1.

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.

Kuno S, Sakurai F, Shimizu K, Matsumura N, Kim S, Watanabe H, Tashiro K, Tachibana M, Yokoi T, Mizuguchi H.

Drug Metab Pharmacokinet. 2014;29(4):296-304. Epub 2014 Feb 4.

2.

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2008 Dec;36(12):2506-12. doi: 10.1124/dmd.108.022723. Epub 2008 Sep 17.

3.

Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.

Granvil CP, Yu AM, Elizondo G, Akiyama TE, Cheung C, Feigenbaum L, Krausz KW, Gonzalez FJ.

Drug Metab Dispos. 2003 May;31(5):548-58.

4.

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.

Koizumi N, Mizuguchi H, Sakurai F, Yamaguchi T, Watanabe Y, Hayakawa T.

J Virol. 2003 Dec;77(24):13062-72.

5.

Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer.

Lu H, Chen CS, Waxman DJ.

Cancer Gene Ther. 2009 May;16(5):393-404. doi: 10.1038/cgt.2008.93. Epub 2008 Nov 14.

6.

A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.

Mitsui T, Nemoto T, Miyake T, Nagao S, Ogawa K, Kato M, Ishigai M, Yamada H.

Drug Metab Dispos. 2014 Sep;42(9):1540-7. doi: 10.1124/dmd.114.057935. Epub 2014 Jul 8.

7.

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver.

Emoto C, Yamato Y, Sato Y, Ohshita H, Katoh M, Tateno C, Yokoi T, Yoshizato K, Iwasaki K.

Xenobiotica. 2008 Mar;38(3):239-48. doi: 10.1080/00498250701760159 .

PMID:
18274954
8.

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.

van Waterschoot RA, Rooswinkel RW, Sparidans RW, van Herwaarden AE, Beijnen JH, Schinkel AH.

Drug Metab Dispos. 2009 Dec;37(12):2305-13. doi: 10.1124/dmd.109.029397. Epub 2009 Sep 14.

9.

Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.

Hasegawa M, Tahara H, Inoue R, Kakuni M, Tateno C, Ushiki J.

Drug Metab Dispos. 2012 Mar;40(3):474-80. doi: 10.1124/dmd.111.042754. Epub 2011 Nov 29.

10.

Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.

Mei Q, Tang C, Assang C, Lin Y, Slaughter D, Rodrigues AD, Baillie TA, Rushmore TH, Shou M.

J Pharmacol Exp Ther. 1999 Nov;291(2):749-59.

11.
12.

An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells.

Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY.

Exp Mol Med. 2008 Apr 30;40(2):254-60.

13.

In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism.

Kim SB, Yoon IS, Kim KS, Cho SJ, Kim YS, Cho HJ, Chung SJ, Chong S, Kim DD.

Planta Med. 2014 May;80(7):561-7. doi: 10.1055/s-0034-1368350. Epub 2014 Apr 7.

PMID:
24710899
14.

Up-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-AD.

Chen F, Rao XH, Yang JL, Pan MX, Gao Y, Li ZL, Li Y, Zhu YF, Wang Y.

PLoS One. 2014 May 1;9(5):e95752. doi: 10.1371/journal.pone.0095752. eCollection 2014.

15.

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.

Barter ZE, Perrett HF, Yeo KR, Allorge D, Lennard MS, Rostami-Hodjegan A.

Biopharm Drug Dispos. 2010 Nov;31(8-9):516-32. doi: 10.1002/bdd.732.

PMID:
21104927
16.

CYP3A4 is a human microsomal vitamin D 25-hydroxylase.

Gupta RP, Hollis BW, Patel SB, Patrick KS, Bell NH.

J Bone Miner Res. 2004 Apr;19(4):680-8. Epub 2003 Dec 22.

17.

Cytochrome P450 3A-mediated microsomal biotransformation of 1α,25-dihydroxyvitamin D3 in mouse and human liver: drug-related induction and inhibition of catabolism.

Deb S, Pandey M, Adomat H, Guns ES.

Drug Metab Dispos. 2012 May;40(5):907-18. doi: 10.1124/dmd.111.041681. Epub 2012 Feb 2.

18.

Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.

Klees TM, Sheffels P, Thummel KE, Kharasch ED.

Anesthesiology. 2005 Mar;102(3):550-6.

PMID:
15731592
19.

The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.

Gallagher EP, Kunze KL, Stapleton PL, Eaton DL.

Toxicol Appl Pharmacol. 1996 Dec;141(2):595-606.

PMID:
8975785
20.

Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.

Gorziglia MI, Lapcevich C, Roy S, Kang Q, Kadan M, Wu V, Pechan P, Kaleko M.

J Virol. 1999 Jul;73(7):6048-55.

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