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Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival.

Funes JM, Henderson S, Kaufman R, Flanagan JM, Robson M, Pedley B, Moncada S, Boshoff C.

Mol Cancer. 2014 Feb 3;13:20. doi: 10.1186/1476-4598-13-20.


BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.


NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity.

Manandhar S, Choi BH, Jung KA, Ryoo IG, Song M, Kang SJ, Choi HG, Kim JA, Park PH, Kwak MK.

Free Radic Biol Med. 2012 May 1;52(9):1773-85. doi: 10.1016/j.freeradbiomed.2012.02.031. Epub 2012 Mar 3.


Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.

Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S.

Cancer Res. 2010 Nov 15;70(22):9095-105. doi: 10.1158/0008-5472.CAN-10-0384. Epub 2010 Nov 9.


Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation.

Yang Y, Cai X, Yang J, Sun X, Hu C, Yan Z, Xu X, Lu W, Wang X, Cao P.

Mol Cancer. 2014 Mar 6;13:48. doi: 10.1186/1476-4598-13-48.


The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis.

Frohlich DA, McCabe MT, Arnold RS, Day ML.

Oncogene. 2008 Jul 17;27(31):4353-62. doi: 10.1038/onc.2008.79. Epub 2008 Mar 31.


Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.

Cheung KL, Lee JH, Khor TO, Wu TY, Li GX, Chan J, Yang CS, Kong AN.

Mol Carcinog. 2014 Jan;53(1):77-84. doi: 10.1002/mc.21950. Epub 2012 Aug 21.


Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer.

Singh B, Chatterjee A, Ronghe AM, Bhat NK, Bhat HK.

BMC Cancer. 2013 May 22;13:253. doi: 10.1186/1471-2407-13-253.


Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells.

Son YO, Pratheeshkumar P, Divya SP, Zhang Z, Shi X.

J Biol Chem. 2017 May 19;292(20):8315-8330. doi: 10.1074/jbc.M116.773986. Epub 2017 Mar 22.


Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.

Wu TY, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.

AAPS J. 2011 Mar;13(1):1-13. doi: 10.1208/s12248-010-9239-4. Epub 2010 Oct 22.


Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system.

Ye S, Chen M, Jiang Y, Chen M, Zhou T, Wang Y, Hou Z, Ren L.

Int J Nanomedicine. 2014 Apr 29;9:2073-87. doi: 10.2147/IJN.S56973. eCollection 2014.


A 3D rotary renal and mesenchymal stem cell culture model unveils cell death mechanisms induced by matrix deficiency and low shear stress.

Shimony N, Avrahami I, Gorodetsky R, Elkin G, Tzukert K, Zangi L, Levdansky L, Krasny L, Haviv YS.

Nephrol Dial Transplant. 2008 Jun;23(6):2071-80. doi: 10.1093/ndt/gfn062. Epub 2008 Mar 14.


Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model.

Ji XJ, Chen SH, Zhu L, Pan H, Zhou Y, Li W, You WC, Gao CC, Zhu JH, Jiang K, Wang HD.

Oncol Rep. 2013 Jul;30(1):157-64. doi: 10.3892/or.2013.2476. Epub 2013 May 15.


The Roles of 4β-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.

Peng CY, You BJ, Lee CL, Wu YC, Lin WH, Lu TL, Chang FC, Lee HZ.

Am J Chin Med. 2016;44(3):617-36. doi: 10.1142/S0192415X16500348. Epub 2016 Apr 24.


Semaphorin-plexin signalling genes associated with human breast tumourigenesis.

Gabrovska PN, Smith RA, Tiang T, Weinstein SR, Haupt LM, Griffiths LR.

Gene. 2011 Dec 10;489(2):63-9. doi: 10.1016/j.gene.2011.08.024. Epub 2011 Sep 2.


Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer.

Ma X, Zhang J, Liu S, Huang Y, Chen B, Wang D.

Cancer Chemother Pharmacol. 2012 Feb;69(2):485-94. doi: 10.1007/s00280-011-1722-9. Epub 2011 Aug 13.


Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene.

Vasseur S, Malicet C, Calvo EL, Labrie C, Berthezene P, Dagorn JC, Iovanna JL.

Mol Cancer. 2003 Mar 19;2:19.


Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1α signaling in human epithelial ovarian cancer.

Zhang Z, Wang Q, Ma J, Yi X, Zhu Y, Xi X, Feng Y, Jin Z.

Oncol Rep. 2013 Apr;29(4):1429-34. doi: 10.3892/or.2013.2278. Epub 2013 Feb 6.


Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications.

Saidu NE, Noé G, Cerles O, Cabel L, Kavian-Tessler N, Chouzenoux S, Bahuaud M, Chéreau C, Nicco C, Leroy K, Borghese B, Goldwasser F, Batteux F, Alexandre J.

Mol Cancer Ther. 2017 Mar;16(3):529-539. doi: 10.1158/1535-7163.MCT-16-0405. Epub 2017 Jan 9.

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