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Items: 1 to 20 of 148

1.

Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.

Carlson TJ, Pellerin A, Djuretic IM, Trivigno C, Koralov SB, Rao A, Sundrud MS.

J Immunol. 2014 Mar 1;192(5):2167-76. doi: 10.4049/jimmunol.1302316. Epub 2014 Jan 31.

2.

Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region.

Guo W, Luo C, Wang C, Wang YH, Wang X, Gao XD, Yao WB.

Int J Biochem Cell Biol. 2014 Oct;55:304-10. doi: 10.1016/j.biocel.2014.09.019. Epub 2014 Sep 26.

PMID:
25263529
3.

Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22.

Raifer H, Mahiny AJ, Bollig N, Petermann F, Hellhund A, Kellner K, Guralnik A, Reinhard K, Bothur E, Huber M, Bauer S, Löhning M, Kiss EA, Ganal SC, Diefenbach A, Korn T, Lohoff M.

Eur J Immunol. 2012 Dec;42(12):3189-201. doi: 10.1002/eji.201142155. Epub 2012 Oct 17.

4.

IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system.

Li H, Nourbakhsh B, Cullimore M, Zhang GX, Rostami A.

Eur J Immunol. 2011 Aug;41(8):2197-206. doi: 10.1002/eji.201041125. Epub 2011 Jul 6.

5.

Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.

Floss DM, Mrotzek S, Klöcker T, Schröder J, Grötzinger J, Rose-John S, Scheller J.

J Biol Chem. 2013 Jul 5;288(27):19386-400. doi: 10.1074/jbc.M112.432153. Epub 2013 May 14.

6.

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity.

Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C.

Cell Rep. 2017 Oct 3;21(1):195-207. doi: 10.1016/j.celrep.2017.09.021.

7.

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells.

Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KP, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR.

Nat Commun. 2015 Oct 29;6:8644. doi: 10.1038/ncomms9644.

8.

Stat3 programs Th17-specific regulatory T cells to control GN.

Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RA, Panzer U, Steinmetz OM.

J Am Soc Nephrol. 2014 Jun;25(6):1291-302. doi: 10.1681/ASN.2013080904. Epub 2014 Feb 7.

9.

IFN-beta inhibits human Th17 cell differentiation.

Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S.

J Immunol. 2009 Oct 15;183(8):5418-27. doi: 10.4049/jimmunol.0803227. Epub 2009 Sep 25.

10.

Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS Jr.

PLoS One. 2012;7(5):e33518. doi: 10.1371/journal.pone.0033518. Epub 2012 May 10.

11.

Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.

Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T.

J Immunol. 2014 Feb 15;192(4):1512-24. doi: 10.4049/jimmunol.1301619. Epub 2014 Jan 10.

12.

A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.

Yu RY, Gallagher G.

J Immunol. 2010 Dec 15;185(12):7302-8. doi: 10.4049/jimmunol.1002410. Epub 2010 Nov 12.

13.

miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3.

Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z.

J Immunol. 2014 Jun 15;192(12):5599-609. doi: 10.4049/jimmunol.1303488. Epub 2014 May 19.

14.

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.

Science. 2009 Jun 5;324(5932):1334-8. doi: 10.1126/science.1172638.

15.

Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.

Ulges A, Witsch EJ, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F, Bopp T.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10145-50. doi: 10.1073/pnas.1523869113. Epub 2016 Aug 23.

16.

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.

Ma J, McCarl CA, Khalil S, Lüthy K, Feske S.

Eur J Immunol. 2010 Nov;40(11):3028-42. doi: 10.1002/eji.201040614. Epub 2010 Oct 27.

17.

Halofuginone ameliorates autoimmune arthritis in mice by regulating the balance between Th17 and Treg cells and inhibiting osteoclastogenesis.

Park MK, Park JS, Park EM, Lim MA, Kim SM, Lee DG, Baek SY, Yang EJ, Woo JW, Lee J, Kwok SK, Kim HY, Cho ML, Park SH.

Arthritis Rheumatol. 2014 May;66(5):1195-207. doi: 10.1002/art.38313.

18.

IL-23 drives differentiation of peripheral γδ17 T cells from adult bone marrow-derived precursors.

Papotto PH, Gonçalves-Sousa N, Schmolka N, Iseppon A, Mensurado S, Stockinger B, Ribot JC, Silva-Santos B.

EMBO Rep. 2017 Nov;18(11):1957-1967. doi: 10.15252/embr.201744200. Epub 2017 Aug 30.

19.

Expression of IL-23/Th17 pathway in a murine model of Coxsackie virus B3-induced viral myocarditis.

Yang F, Wu WF, Yan YL, Pang Y, Kong Q, Huang YL.

Virol J. 2011 Jun 14;8:301. doi: 10.1186/1743-422X-8-301.

20.

CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE.

Simpson-Abelson MR, Hernandez-Mir G, Childs EE, Cruz JA, Poholek AC, Chattopadhyay A, Gaffen SL, McGeachy MJ.

Cytokine. 2017 Apr;92:24-32. doi: 10.1016/j.cyto.2017.01.005. Epub 2017 Jan 12.

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