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Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions.

Huang W, Tang S, Qiao X, Ma W, Ji S, Wang K, Ye M, Yu S.

Fitoterapia. 2014 Apr;94:36-47. doi: 10.1016/j.fitote.2014.01.016. Epub 2014 Jan 30.


Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway.

Seon MR, Lim SS, Choi HJ, Park SY, Cho HJ, Kim JK, Kim J, Kwon DY, Park JH.

Mol Nutr Food Res. 2010 Sep;54(9):1329-39. doi: 10.1002/mnfr.200900260.


Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB.

Moghadamtousi SZ, Kadir HA, Paydar M, Rouhollahi E, Karimian H.

BMC Complement Altern Med. 2014 Aug 15;14:299. doi: 10.1186/1472-6882-14-299.


Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway.

Won SH, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Jung DB, Shin JM, Kwon TR, Yun SM, Lee MH, Choi SH, Lü J, Kim SH.

Biol Pharm Bull. 2010;33(11):1828-34.


A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway.

Cao W, Li XQ, Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB.

Phytomedicine. 2010 Jul;17(8-9):598-605. doi: 10.1016/j.phymed.2009.12.014. Epub 2010 Jan 25.


Molecular mechanism of apoptosis induction in skin cancer cells by the centipedegrass extract.

Badaboina S, Bai HW, Park CH, Jang DM, Choi BY, Chung BY.

BMC Complement Altern Med. 2013 Dec 11;13:350. doi: 10.1186/1472-6882-13-350.


Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells.

Hirchaud F, Hermetet F, Ablise M, Fauconnet S, Vuitton DA, Prétet JL, Mougin C.

Planta Med. 2013 Nov;79(17):1628-35. doi: 10.1055/s-0033-1350956. Epub 2013 Nov 8.


Aqueous fraction of Nephelium ramboutan-ake rind induces mitochondrial-mediated apoptosis in HT-29 human colorectal adenocarcinoma cells.

Chan CK, Goh BH, Kamarudin MN, Kadir HA.

Molecules. 2012 May 31;17(6):6633-57. doi: 10.3390/molecules17066633.


A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.

Khan S, Kaur R, Shah BA, Malik F, Kumar A, Bhushan S, Jain SK, Taneja SC, Singh J.

Mol Carcinog. 2012 Sep;51(9):679-95. doi: 10.1002/mc.20821. Epub 2011 Jul 12.


Chamaejasmine induces apoptosis in human lung adenocarcinoma A549 cells through a Ros-mediated mitochondrial pathway.

Yu H, Zhang T, Cai L, Qu Y, Hu S, Dong G, Guan R, Xu X, Xing L.

Molecules. 2011 Sep 27;16(10):8165-80. doi: 10.3390/molecules16108165.


Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways.

Rasul A, Khan M, Yu B, Ali M, Bo YJ, Yang H, Ma T.

Arch Pharm Res. 2013 Oct;36(10):1262-9. doi: 10.1007/s12272-013-0217-0. Epub 2013 Jul 24.


Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways.

Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, Arya A, Wong WF, Mustafa MR.

BMC Complement Altern Med. 2013 Jul 10;13:166. doi: 10.1186/1472-6882-13-166.


TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells.

Jin HJ, Xie XL, Ye JM, Li CG.

PLoS One. 2013;8(1):e51720. doi: 10.1371/journal.pone.0051720. Epub 2013 Jan 14.


Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells.

Seon MR, Park SY, Kwon SJ, Lim SS, Choi HJ, Park H, Lim DY, Kim JS, Lee CH, Kim J, Park JH.

J Nutr Biochem. 2012 Jan;23(1):85-92. doi: 10.1016/j.jnutbio.2010.11.010. Epub 2011 Mar 22.


Longan flower extract inhibits the growth of colorectal carcinoma.

Hsu CP, Lin YH, Zhou SP, Chung YC, Lin CC, Wang SC.

Nutr Cancer. 2010;62(2):229-36. doi: 10.1080/01635580903305367.


Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells.

Kuo HM, Tsai HC, Lin YL, Yang JS, Huang AC, Yang MD, Hsu SC, Chung MC, Gibson Wood W, Chung JG.

Int J Oncol. 2009 Oct;35(4):717-24.


Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells.

Ju HK, Lee HW, Chung KS, Choi JH, Cho JG, Baek NI, Chung HG, Lee KT.

J Ethnopharmacol. 2012 May 7;141(1):460-8. doi: 10.1016/j.jep.2012.03.011. Epub 2012 Mar 18.


Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.

Huang WW, Ko SW, Tsai HY, Chung JG, Chiang JH, Chen KT, Chen YC, Chen HY, Chen YF, Yang JS.

Int J Oncol. 2011 Apr;38(4):1067-73. doi: 10.3892/ijo.2011.922. Epub 2011 Jan 24.


A novel synthetic 2-(3-methoxyphenyl)-6,7-methylenedioxoquinolin-4-one arrests the G2/M phase arrest via Cdc25c and induces apoptosis through caspase- and mitochondria-dependent pathways in TSGH8301 human bladder cancer cells.

Hsu SC, Yu CC, Yang JS, Lai KC, Wu SH, Lin JJ, Kuo JH, Yang ST, Huang CC, Kuo SC, Chung JG.

Int J Oncol. 2012 Mar;40(3):731-8. doi: 10.3892/ijo.2011.1241. Epub 2011 Oct 21.

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