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Items: 1 to 20 of 104

1.

Safety, tolerability, pharmacokinetics, and effects on human experimental pain of the selective ionotropic glutamate receptor 5 (iGluR5) antagonist LY545694 in healthy volunteers.

Petersen KL, Iyengar S, Chappell AS, Lobo ED, Reda H, Prucka WR, Verfaille SJ.

Pain. 2014 May;155(5):929-36. doi: 10.1016/j.pain.2014.01.019.

PMID:
24486883
2.

Results from clinical trials of a selective ionotropic glutamate receptor 5 (iGluR5) antagonist, LY5454694 tosylate, in 2 chronic pain conditions.

Chappell AS, Iyengar S, Lobo ED, Prucka WR.

Pain. 2014 Jun;155(6):1140-9. doi: 10.1016/j.pain.2014.02.023.

PMID:
24631589
3.

NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.

Wallace MS, Lam V, Schettler J.

Pain Med. 2012 Dec;13(12):1601-10. doi: 10.1111/j.1526-4637.2012.01509.x.

4.
5.

Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: a randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers.

Lal R, Sukbuntherng J, Luo W, Chen D, Vu A, Tovera J, Cundy KC.

Clin Ther. 2009 Aug;31(8):1776-86. doi: 10.1016/j.clinthera.2009.07.026.

PMID:
19808136
6.

Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor, HM30181, in healthy Korean male volunteers: single- and multiple-dose randomized, placebo-controlled studies.

Kim TE, Gu N, Yoon SH, Cho JY, Park KM, Shin SG, Jang IJ, Yu KS.

Clin Ther. 2012 Feb;34(2):482-94. doi: 10.1016/j.clinthera.2012.01.003.

PMID:
22284902
7.

The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.

Gustorff B, Hoechtl K, Sycha T, Felouzis E, Lehr S, Kress HG.

Anesth Analg. 2004 Feb;98(2):401-7, table of contents.

PMID:
14742378
9.

Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study.

Bone M, Critchley P, Buggy DJ.

Reg Anesth Pain Med. 2002 Sep-Oct;27(5):481-6.

PMID:
12373695
11.

Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect.

Duedahl TH, Dirks J, Petersen KB, Romsing J, Larsen NE, Dahl JB.

Pain. 2005 Feb;113(3):360-8.

PMID:
15661445
12.

The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study.

Gormsen L, Finnerup NB, Almqvist PM, Jensen TS.

Anesth Analg. 2009 Apr;108(4):1311-9. doi: 10.1213/ane.0b013e318198317b.

PMID:
19299805
13.

The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.

Lee HJ, Pogatzki-Zahn EM, Brennan TJ.

J Pain. 2006 Oct;7(10):768-77.

PMID:
17018337
14.
15.

Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers.

Vaughan D, Speed J, Medve R, Andrews JS.

Clin Ther. 2010 Jan;32(1):146-60. doi: 10.1016/j.clinthera.2010.01.006.

PMID:
20171420
16.

Pharmacokinetic comparison of sustained- and immediate-release oral formulations of cilostazol in healthy Korean subjects: a randomized, open-label, 3-part, sequential, 2-period, crossover, single-dose, food-effect, and multiple-dose study.

Lee D, Lim LA, Jang SB, Lee YJ, Chung JY, Choi JR, Kim K, Park JW, Yoon H, Lee J, Park MS, Park K.

Clin Ther. 2011 Dec;33(12):2038-53. doi: 10.1016/j.clinthera.2011.10.024.

PMID:
22129569
17.

AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.

Sang CN, Hostetter MP, Gracely RH, Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max MB.

Anesthesiology. 1998 Nov;89(5):1060-7.

PMID:
9821993
19.
20.

Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects.

Chi YH, Lee H, Paik SH, Lee JH, Yoo BW, Kim JH, Tan HK, Kim SL.

Am J Cardiovasc Drugs. 2011 Oct 1;11(5):335-46. doi: 10.2165/11593840-000000000-00000.

PMID:
21910510
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