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Items: 1 to 20 of 228

1.

SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.

Shin SY, Kim TH, Wu H, Choi YH, Kim SG.

Eur J Pharmacol. 2014 Mar 15;727:115-24. doi: 10.1016/j.ejphar.2014.01.035. Epub 2014 Jan 30.

PMID:
24486702
2.

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.

Kim TH, Eom JS, Lee CG, Yang YM, Lee YS, Kim SG.

Br J Pharmacol. 2013 Apr;168(7):1647-61. doi: 10.1111/bph.12057.

3.

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase.

Chen WL, Kang CH, Wang SG, Lee HM.

Diabetologia. 2012 Jun;55(6):1824-35. doi: 10.1007/s00125-012-2530-4. Epub 2012 Mar 30.

PMID:
22456698
4.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.

5.

Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway.

Yu JW, Sun LJ, Liu W, Zhao YH, Kang P, Yan BZ.

Int J Infect Dis. 2013 Jul;17(7):e539-45. doi: 10.1016/j.ijid.2013.01.027. Epub 2013 Mar 16.

6.
7.

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.

Jin SH, Yang JH, Shin BY, Seo K, Shin SM, Cho IJ, Ki SH.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):95-105. doi: 10.1016/j.taap.2013.04.023. Epub 2013 May 5.

PMID:
23651738
8.

Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Han CY, Ki SH, Kim YW, Noh K, Lee DY, Kang B, Ryu JH, Jeon R, Kim EH, Hwang SJ, Kim SG.

Antioxid Redox Signal. 2011 Jan 15;14(2):187-202. doi: 10.1089/ars.2010.3190. Epub 2010 Sep 6.

PMID:
20560786
9.

Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.

Lee J, Hong SW, Chae SW, Kim DH, Choi JH, Bae JC, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY.

PLoS One. 2012;7(2):e31394. doi: 10.1371/journal.pone.0031394. Epub 2012 Feb 17.

10.

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.

Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J.

FASEB J. 2014 Jul;28(7):3225-37. doi: 10.1096/fj.13-245241. Epub 2014 Mar 31.

11.

Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells.

Hwang YP, Choi JH, Kim HG, Lee HS, Chung YC, Jeong HG.

Food Chem. 2013 Sep 1;140(1-2):115-23. doi: 10.1016/j.foodchem.2013.02.041. Epub 2013 Feb 21.

PMID:
23578622
12.

3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway.

Pil Hwang Y, Gyun Kim H, Choi JH, Truong Do M, Tran TP, Chun HK, Chung YC, Jeong TC, Jeong HG.

Mol Nutr Food Res. 2013 Mar;57(3):471-82. doi: 10.1002/mnfr.201200529. Epub 2013 Jan 24.

PMID:
23349077
13.

Involvement of mammalian sirtuin 1 in the action of ethanol in the liver.

You M, Liang X, Ajmo JM, Ness GC.

Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G892-8. doi: 10.1152/ajpgi.00575.2007. Epub 2008 Jan 31.

14.

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.

Li H, Xu M, Lee J, He C, Xie Z.

Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1234-44. doi: 10.1152/ajpendo.00198.2012. Epub 2012 Sep 11.

15.

Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.

Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM.

Food Chem Toxicol. 2014 Feb;64:94-103. doi: 10.1016/j.fct.2013.11.015. Epub 2013 Nov 22.

PMID:
24275089
16.

Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice.

Shen Z, Liang X, Rogers CQ, Rideout D, You M.

Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G364-74. doi: 10.1152/ajpgi.00456.2009. Epub 2009 Dec 10.

17.

Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.

Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B.

Biochem Pharmacol. 2014 Sep 1;91(1):74-86. doi: 10.1016/j.bcp.2014.07.002. Epub 2014 Jul 12.

PMID:
25026599
18.

Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation.

Castaño D, Larequi E, Belza I, Astudillo AM, Martínez-Ansó E, Balsinde J, Argemi J, Aragon T, Moreno-Aliaga MJ, Muntane J, Prieto J, Bustos M.

J Hepatol. 2014 May;60(5):1017-25. doi: 10.1016/j.jhep.2013.12.012. Epub 2013 Dec 19.

PMID:
24362075
19.

Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in streptozotocin-diabetic rat.

Barazzoni R, Zanetti M, Sturnega M, Stebel M, Semolic A, Pirulli A, Vinci P, Zentilin L, Giacca M, Cattin L, Guarnieri G.

Clin Nutr. 2011 Jun;30(3):384-90. doi: 10.1016/j.clnu.2010.11.001. Epub 2010 Nov 24.

PMID:
21106280
20.

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.

Yang SJ, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.

J Nutr Biochem. 2014 Jan;25(1):66-72. doi: 10.1016/j.jnutbio.2013.09.004. Epub 2013 Oct 10.

PMID:
24314867

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