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Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis.

Tampe B, Tampe D, Müller CA, Sugimoto H, LeBleu V, Xu X, Müller GA, Zeisberg EM, Kalluri R, Zeisberg M.

J Am Soc Nephrol. 2014 May;25(5):905-12. doi: 10.1681/ASN.2013070723. Epub 2014 Jan 30.


Hypermethylation of RASAL1: A Key for Renal Fibrosis.

Mao Y.

EBioMedicine. 2014 Oct 28;2(1):7-8. doi: 10.1016/j.ebiom.2014.10.016. eCollection 2014 Oct 28. No abstract available.


Genetics: epigenetic reversal attenuates renal fibrosis.

Holmes D.

Nat Rev Nephrol. 2014 Apr;10(4):184. doi: 10.1038/nrneph.2014.21. Epub 2014 Feb 18. No abstract available.


Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.

Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM.

Cardiovasc Res. 2015 Mar 1;105(3):279-91. doi: 10.1093/cvr/cvv015. Epub 2015 Jan 23.


Epigenetic unsilencing reverses renal fibrosis.

Higgins DF, Murphy M.

J Am Soc Nephrol. 2014 May;25(5):865-6. doi: 10.1681/ASN.2014010006. Epub 2014 Jan 30. No abstract available.


The role of promoter hypermethylation in fibroblast activation and fibrogenesis.

Zeisberg EM, Zeisberg M.

J Pathol. 2013 Jan;229(2):264-73. doi: 10.1002/path.4120. Review.


Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.

Pan Z, Zhang M, Ma T, Xue ZY, Li GF, Hao LY, Zhu LJ, Li YQ, Ding HL, Cao JL.

J Neurosci. 2016 Mar 2;36(9):2769-81. doi: 10.1523/JNEUROSCI.3474-15.2016.


Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.

Chen H, Kazemier HG, de Groote ML, Ruiters MH, Xu GL, Rots MG.

Nucleic Acids Res. 2014 Feb;42(3):1563-74. doi: 10.1093/nar/gkt1019. Epub 2013 Nov 4.


Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts.

Sanders YY, Tollefsbol TO, Varisco BM, Hagood JS.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):16-23. doi: 10.1165/rcmb.2010-0154OC. Epub 2010 Aug 19.


The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis.

Dees C, Schlottmann I, Funke R, Distler A, Palumbo-Zerr K, Zerr P, Lin NY, Beyer C, Distler O, Schett G, Distler JH.

Ann Rheum Dis. 2014 Jun;73(6):1232-9. doi: 10.1136/annrheumdis-2012-203194. Epub 2013 May 22.


Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium.

Zhang C, Liang Y, Lei L, Zhu G, Chen X, Jin T, Wu Q.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):78-85. doi: 10.1016/j.taap.2013.04.025. Epub 2013 May 9.


Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M, Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC Jr, Yu Y.

Cancer Res. 2003 Jul 15;63(14):4174-80.


A global profile of gene promoter methylation in treatment-naïve urothelial cancer.

Ibragimova I, Dulaimi E, Slifker MJ, Chen DY, Uzzo RG, Cairns P.

Epigenetics. 2014 May;9(5):760-73. doi: 10.4161/epi.28078. Epub 2014 Feb 12.


Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer.

Liu WB, Han F, Du XH, Jiang X, Li YH, Liu Y, Chen HQ, Ao L, Cui ZH, Cao J, Liu JY.

Int J Cancer. 2014 Mar 15;134(6):1311-22. doi: 10.1002/ijc.28472. Epub 2013 Nov 11.


Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression.

Tampe B, Steinle U, Tampe D, Carstens JL, Korsten P, Zeisberg EM, Müller GA, Kalluri R, Zeisberg M.

Kidney Int. 2017 Jan;91(1):157-176. doi: 10.1016/j.kint.2016.07.042. Epub 2016 Sep 28.


Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.

Lin X, Asgari K, Putzi MJ, Gage WR, Yu X, Cornblatt BS, Kumar A, Piantadosi S, DeWeese TL, De Marzo AM, Nelson WG.

Cancer Res. 2001 Dec 15;61(24):8611-6.


Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.

Kron K, Pethe V, Briollais L, Sadikovic B, Ozcelik H, Sunderji A, Venkateswaran V, Pinthus J, Fleshner N, van der Kwast T, Bapat B.

PLoS One. 2009;4(3):e4830. doi: 10.1371/journal.pone.0004830. Epub 2009 Mar 13.


Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker.

Teodoridis JM, Strathdee G, Brown R.

Drug Resist Updat. 2004 Aug-Oct;7(4-5):267-78. Review.


Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting duct.

Yu Z, Kong Q, Kone BC.

Am J Physiol Renal Physiol. 2013 Oct 1;305(7):F1006-13. doi: 10.1152/ajprenal.00407.2013. Epub 2013 Aug 7.


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