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Items: 1 to 20 of 114

1.

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.

Zhang M, Wang S, Mao L, Leak RK, Shi Y, Zhang W, Hu X, Sun B, Cao G, Gao Y, Xu Y, Chen J, Zhang F.

J Neurosci. 2014 Jan 29;34(5):1903-15. doi: 10.1523/JNEUROSCI.4043-13.2014.

2.

4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.

Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H.

PLoS One. 2013 Jul 23;8(7):e69415. doi: 10.1371/journal.pone.0069415.

3.

4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs.

Nakagawa F, Morino K, Ugi S, Ishikado A, Kondo K, Sato D, Konno S, Nemoto K, Kusunoki C, Sekine O, Sunagawa A, Kawamura M, Inoue N, Nishio Y, Maegawa H.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):991-6. doi: 10.1016/j.bbrc.2013.12.085.

PMID:
24361890
4.

Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells.

Ishikado A, Nishio Y, Morino K, Ugi S, Kondo H, Makino T, Kashiwagi A, Maegawa H.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):99-104. doi: 10.1016/j.bbrc.2010.09.124.

PMID:
20920477
5.

Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury.

Zhang F, Wang S, Zhang M, Weng Z, Li P, Gan Y, Zhang L, Cao G, Gao Y, Leak RK, Sporn MB, Chen J.

Stroke. 2012 May;43(5):1390-7. doi: 10.1161/STROKEAHA.111.647420.

6.

S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo.

Shi H, Jing X, Wei X, Perez RG, Ren M, Zhang X, Lou H.

J Neurochem. 2015 Apr;133(2):298-308. doi: 10.1111/jnc.12986.

7.

Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway.

Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, Zhu Y, Guo C, Jia Y, Li Y, Wen A.

Sci Rep. 2014 Nov 11;4:7002. doi: 10.1038/srep07002.

8.

n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling.

Zhang W, Liu J, Hu X, Li P, Leak RK, Gao Y, Chen J.

Stroke. 2015 Oct;46(10):2943-50. doi: 10.1161/STROKEAHA.115.010815.

9.

Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.

Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR.

Transl Res. 2016 Apr;170:57-72. doi: 10.1016/j.trsl.2015.12.002.

PMID:
26746802
10.

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke.

Wang J, Shi Y, Zhang L, Zhang F, Hu X, Zhang W, Leak RK, Gao Y, Chen L, Chen J.

Neurobiol Dis. 2014 Aug;68:91-103. doi: 10.1016/j.nbd.2014.04.014.

11.
12.

Protection against Oxygen-Glucose Deprivation/Reperfusion Injury in Cortical Neurons by Combining Omega-3 Polyunsaturated Acid with Lyciumbarbarum Polysaccharide.

Shi Z, Wu D, Yao JP, Yao X, Huang Z, Li P, Wan JB, He C, Su H.

Nutrients. 2016 Jan 13;8(1). pii: E41. doi: 10.3390/nu8010041.

13.

Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway.

Saw CL, Yang AY, Guo Y, Kong AN.

Food Chem Toxicol. 2013 Dec;62:869-75. doi: 10.1016/j.fct.2013.10.023.

PMID:
24157545
14.

Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes.

Kusunoki C, Yang L, Yoshizaki T, Nakagawa F, Ishikado A, Kondo M, Morino K, Sekine O, Ugi S, Nishio Y, Kashiwagi A, Maegawa H.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):225-30. doi: 10.1016/j.bbrc.2012.10.115.

PMID:
23131562
15.

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia.

Yang C, Zhang X, Fan H, Liu Y.

Brain Res. 2009 Jul 28;1282:133-41. doi: 10.1016/j.brainres.2009.05.009.

PMID:
19445907
16.

Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways.

Yang YC, Lii CK, Wei YL, Li CC, Lu CY, Liu KL, Chen HW.

J Nutr Biochem. 2013 Jan;24(1):204-12. doi: 10.1016/j.jnutbio.2012.05.003.

PMID:
22901690
17.

Resveratrol pretreatment attenuates cerebral ischemic injury by upregulating expression of transcription factor Nrf2 and HO-1 in rats.

Ren J, Fan C, Chen N, Huang J, Yang Q.

Neurochem Res. 2011 Dec;36(12):2352-62. doi: 10.1007/s11064-011-0561-8.

PMID:
21850487
18.

Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells.

Stulnig G, Frisch MT, Crnkovic S, Stiegler P, Sereinigg M, Stacher E, Olschewski H, Olschewski A, Frank S.

Atherosclerosis. 2013 Oct;230(2):406-13. doi: 10.1016/j.atherosclerosis.2013.08.002.

PMID:
24075775
19.

Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction.

Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, Huang Z, Li P, Li J, Zhang L, Saavedra JM, Liao H, Pang T.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):142-54. doi: 10.1016/j.taap.2015.10.001.

PMID:
26440581
20.

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice.

Li L, Zhang X, Cui L, Wang L, Liu H, Ji H, Du Y.

Brain Res. 2013 Feb 25;1497:32-9. doi: 10.1016/j.brainres.2012.12.032.

PMID:
23276496
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