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Items: 1 to 20 of 59

1.

Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development.

Balmer NV, Leist M.

Basic Clin Pharmacol Toxicol. 2014 Jul;115(1):59-68. doi: 10.1111/bcpt.12203. Epub 2014 Mar 3. Review.

2.

In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints.

Bal-Price AK, Hogberg HT, Buzanska L, Lenas P, van Vliet E, Hartung T.

Neurotoxicology. 2010 Sep;31(5):545-54. doi: 10.1016/j.neuro.2009.11.006. Epub 2009 Dec 5.

PMID:
19969020
3.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach.

Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause KH, Hengstler JG, Rahnenführer J, Leist M, Sachinidis A.

Arch Toxicol. 2013 Jan;87(1):123-43. doi: 10.1007/s00204-012-0967-3. Epub 2012 Nov 21.

4.

miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing.

Pallocca G, Fabbri M, Sacco MG, Gribaldo L, Pamies D, Laurenza I, Bal-Price A.

Cell Biol Toxicol. 2013 Aug;29(4):239-57. doi: 10.1007/s10565-013-9250-5. Epub 2013 Aug 1.

PMID:
23903816
5.

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.

Kuegler PB, Zimmer B, Waldmann T, Baudis B, Ilmjärv S, Hescheler J, Gaughwin P, Brundin P, Mundy W, Bal-Price AK, Schrattenholz A, Krause KH, van Thriel C, Rao MS, Kadereit S, Leist M.

ALTEX. 2010;27(1):17-42. Review.

6.

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ.

ALTEX. 2017;34(1):49-74. doi: 10.14573/altex.1604201. Epub 2016 Jul 25.

7.

The DNT-EST: a predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro.

Hayess K, Riebeling C, Pirow R, Steinfath M, Sittner D, Slawik B, Luch A, Seiler AE.

Toxicology. 2013 Dec 6;314(1):135-47. doi: 10.1016/j.tox.2013.09.012. Epub 2013 Oct 2.

PMID:
24096155
8.

An Overview on Human Umbilical Cord Blood Stem Cell-Based Alternative In Vitro Models for Developmental Neurotoxicity Assessment.

Singh AK, Kashyap MP.

Mol Neurobiol. 2016 Jul;53(5):3216-3226. doi: 10.1007/s12035-015-9202-6. Epub 2015 Jun 4. Review.

PMID:
26041658
9.

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach.

Hogberg HT, Kinsner-Ovaskainen A, Coecke S, Hartung T, Bal-Price AK.

Toxicol Sci. 2010 Jan;113(1):95-115. doi: 10.1093/toxsci/kfp175. Epub 2009 Aug 3.

PMID:
19651682
10.

Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology.

Csoka AB, Szyf M.

Med Hypotheses. 2009 Nov;73(5):770-80. doi: 10.1016/j.mehy.2008.10.039. Epub 2009 Jun 5.

PMID:
19501473
11.

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.

Zimmer B, Kuegler PB, Baudis B, Genewsky A, Tanavde V, Koh W, Tan B, Waldmann T, Kadereit S, Leist M.

Cell Death Differ. 2011 Mar;18(3):383-95. doi: 10.1038/cdd.2010.109. Epub 2010 Sep 24.

12.

Epigenetics of memory and plasticity.

Woldemichael BT, Bohacek J, Gapp K, Mansuy IM.

Prog Mol Biol Transl Sci. 2014;122:305-40. doi: 10.1016/B978-0-12-420170-5.00011-8. Review.

PMID:
24484706
13.

Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells.

Theunissen PT, Pennings JL, Robinson JF, Claessen SM, Kleinjans JC, Piersma AH.

Toxicol Sci. 2011 Aug;122(2):437-47. doi: 10.1093/toxsci/kfr134. Epub 2011 May 25.

PMID:
21613230
14.

Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation.

Veazey KJ, Carnahan MN, Muller D, Miranda RC, Golding MC.

Alcohol Clin Exp Res. 2013 Jul;37(7):1111-22. doi: 10.1111/acer.12080. Epub 2013 Mar 12.

15.

Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment.

Trosko JE, Chang CC.

Toxicology. 2010 Mar 30;270(1):18-34. doi: 10.1016/j.tox.2009.11.019. Epub 2009 Dec 3. Review.

PMID:
19948204
16.

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K.

Toxicology. 2015 Sep 1;335:11-9. doi: 10.1016/j.tox.2015.06.009. Epub 2015 Jun 29.

17.

Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.

Niles KM, Yeh JR, Chan D, Landry M, Nagano MC, Trasler JM.

Hum Reprod. 2013 Feb;28(2):519-30. doi: 10.1093/humrep/des395. Epub 2012 Nov 15.

18.

Epigenetic control.

Delcuve GP, Rastegar M, Davie JR.

J Cell Physiol. 2009 May;219(2):243-50. doi: 10.1002/jcp.21678. Review.

PMID:
19127539
19.

The next innovation cycle in toxicogenomics: environmental epigenetics.

Reamon-Buettner SM, Mutschler V, Borlak J.

Mutat Res. 2008 Jul-Aug;659(1-2):158-65. doi: 10.1016/j.mrrev.2008.01.003. Epub 2008 Jan 19. Review.

PMID:
18342568
20.

Epigenetics, stem cells and epithelial cell fate.

Vincent A, Van Seuningen I.

Differentiation. 2009 Sep-Oct;78(2-3):99-107. doi: 10.1016/j.diff.2009.07.002. Epub 2009 Jul 24. Review.

PMID:
19632029

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