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Items: 1 to 20 of 130

1.

A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N.

J Biol Chem. 2014 Mar 7;289(10):7109-20. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28.

2.

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.

Actis M, Inoue A, Evison B, Perry S, Punchihewa C, Fujii N.

Bioorg Med Chem. 2013 Apr 1;21(7):1972-7. doi: 10.1016/j.bmc.2013.01.022. Epub 2013 Jan 22.

PMID:
23395113
3.

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.

Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N.

J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.

4.

Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen.

Hishiki A, Hashimoto H, Hanafusa T, Kamei K, Ohashi E, Shimizu T, Ohmori H, Sato M.

J Biol Chem. 2009 Apr 17;284(16):10552-60. doi: 10.1074/jbc.M809745200. Epub 2009 Feb 10.

5.

Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE.

Mol Cell Biol. 2010 Mar;30(5):1217-30. doi: 10.1128/MCB.00993-09. Epub 2009 Dec 22.

6.

REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).

Shen X, Jun S, O'Neal LE, Sonoda E, Bemark M, Sale JE, Li L.

J Biol Chem. 2006 May 19;281(20):13869-72. Epub 2006 Mar 29.

7.

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

Evison BJ, Actis ML, Wu SZ, Shao Y, Heath RJ, Yang L, Fujii N.

Bioorg Med Chem. 2014 Nov 15;22(22):6333-43. doi: 10.1016/j.bmc.2014.09.058. Epub 2014 Oct 8.

8.

Role of budding yeast Rad18 in repair of HO-induced double-strand breaks.

Hirano Y, Reddy J, Sugimoto K.

DNA Repair (Amst). 2009 Jan 1;8(1):51-9. doi: 10.1016/j.dnarep.2008.08.013. Epub 2008 Oct 11.

9.

NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain.

Pustovalova Y, Maciejewski MW, Korzhnev DM.

J Mol Biol. 2013 Sep 9;425(17):3091-105. doi: 10.1016/j.jmb.2013.05.029. Epub 2013 Jun 7.

PMID:
23747975
10.

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.

Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT.

Nat Struct Mol Biol. 2010 Apr;17(4):479-84. doi: 10.1038/nsmb.1776. Epub 2010 Mar 21.

11.

A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.

Albertella MR, Green CM, Lehmann AR, O'Connor MJ.

Cancer Res. 2005 Nov 1;65(21):9799-806.

12.

Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs.

Sanders MA, Haynes B, Nangia-Makker P, Polin LA, Shekhar MP.

J Biol Chem. 2017 Jun 23;292(25):10347-10363. doi: 10.1074/jbc.M117.792192. Epub 2017 May 10.

PMID:
28490629
13.

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.

Bienko M, Green CM, Sabbioneda S, Crosetto N, Matic I, Hibbert RG, Begovic T, Niimi A, Mann M, Lehmann AR, Dikic I.

Mol Cell. 2010 Feb 12;37(3):396-407. doi: 10.1016/j.molcel.2009.12.039.

14.

The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen.

Dong X, Guan J, Zheng C, Zheng X.

J Biol Chem. 2017 May 19;292(20):8472-8483. doi: 10.1074/jbc.M117.778076. Epub 2017 Mar 27.

PMID:
28348081
15.

Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.

16.

Regulatory role of ubiquitin in eukaryotic DNA translesion synthesis.

Yang K, Weinacht CP, Zhuang Z.

Biochemistry. 2013 May 14;52(19):3217-28. doi: 10.1021/bi400194r. Epub 2013 May 1. Review.

PMID:
23634825
17.

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

Ghosal G, Leung JW, Nair BC, Fong KW, Chen J.

J Biol Chem. 2012 Oct 5;287(41):34225-33. doi: 10.1074/jbc.M112.400135. Epub 2012 Aug 17.

18.

Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples.

Spanswick VJ, Lowe HL, Newton C, Bingham JP, Bagnobianchi A, Kiakos K, Craddock C, Ledermann JA, Hochhauser D, Hartley JA.

BMC Cancer. 2012 Sep 28;12:436. doi: 10.1186/1471-2407-12-436.

19.

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.

Terai K, Abbas T, Jazaeri AA, Dutta A.

Mol Cell. 2010 Jan 15;37(1):143-9. doi: 10.1016/j.molcel.2009.12.018.

20.

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.

Geng L, Huntoon CJ, Karnitz LM.

J Cell Biol. 2010 Oct 18;191(2):249-57. doi: 10.1083/jcb.201005101. Epub 2010 Oct 11.

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