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Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.

Salama SA, Mohammad MA, Diaz-Arrastia CR, Kamel MW, Kilic GS, Ndofor BT, Abdel-Baki MS, Theiler SK.

J Clin Endocrinol Metab. 2014 Oct;99(10):3790-9. doi: 10.1210/jc.2013-2639. Epub 2014 Jan 28.


Palmitoylation regulates 17β-estradiol-induced estrogen receptor-α degradation and transcriptional activity.

La Rosa P, Pesiri V, Leclercq G, Marino M, Acconcia F.

Mol Endocrinol. 2012 May;26(5):762-74. doi: 10.1210/me.2011-1208. Epub 2012 Mar 22.


Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.

Bhat-Nakshatri P, Song EK, Collins NR, Uversky VN, Dunker AK, O'Malley BW, Geistlinger TR, Carroll JS, Brown M, Nakshatri H.

BMC Med Genomics. 2013 Jun 11;6:21. doi: 10.1186/1755-8794-6-21.


Estrogen receptor α L429 and A430 regulate 17β-estradiol-induced cell proliferation via CREB1.

Pesiri V, Totta P, Segatto M, Bianchi F, Pallottini V, Marino M, Acconcia F.

Cell Signal. 2015 Dec;27(12):2380-8. doi: 10.1016/j.cellsig.2015.08.021. Epub 2015 Sep 5.


The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S, Maggiolini M.

Mol Endocrinol. 2006 Mar;20(3):631-46. Epub 2005 Oct 20.


Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.

Gao Z, Cooper TA.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13570-5. doi: 10.1073/pnas.1308806110. Epub 2013 Jul 30.


Identification of an estrogen receptor α non covalent ubiquitin-binding surface: role in 17β-estradiol-induced transcriptional activity.

Pesiri V, La Rosa P, Stano P, Acconcia F.

J Cell Sci. 2013 Jun 15;126(Pt 12):2577-82. doi: 10.1242/jcs.123307. Epub 2013 Apr 16.


Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate.

Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi H, Takahashi K, Kurachi H.

Endocrinology. 2010 Jan;151(1):394-405. doi: 10.1210/en.2009-0721. Epub 2009 Nov 24.


Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.

Iqbal MA, Bamezai RN.

PLoS One. 2012;7(5):e36764. doi: 10.1371/journal.pone.0036764. Epub 2012 May 4.


PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop.

Luan W, Wang Y, Chen X, Shi Y, Wang J, Zhang J, Qian J, Li R, Tao T, Wei W, Hu Q, Liu N, You Y.

Oncotarget. 2015 May 30;6(15):13006-18.


The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo.

Abot A, Fontaine C, Raymond-Letron I, Flouriot G, Adlanmerini M, Buscato M, Otto C, Bergès H, Laurell H, Gourdy P, Lenfant F, Arnal JF.

Endocrinology. 2013 Jun;154(6):2222-33. doi: 10.1210/en.2012-2059. Epub 2013 Apr 11.


Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.

Tamada M, Suematsu M, Saya H.

Clin Cancer Res. 2012 Oct 15;18(20):5554-61. doi: 10.1158/1078-0432.CCR-12-0859. Review.


Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P.

Oncotarget. 2015 Sep 15;6(27):24061-74.


Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP.

Cancer Biol Ther. 2011 Dec 15;12(12):1101-13. doi: 10.4161/cbt.12.12.18703. Epub 2011 Dec 15.


Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.

Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15.


Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer.

Feng C, Gao Y, Wang C, Yu X, Zhang W, Guan H, Shan Z, Teng W.

J Clin Endocrinol Metab. 2013 Sep;98(9):E1524-33. doi: 10.1210/jc.2012-4258. Epub 2013 Jul 11.


JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, Wang WC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):279-84. doi: 10.1073/pnas.1311249111. Epub 2013 Dec 16.


HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T, Adjaye J.

Stem Cells. 2014 Feb;32(2):364-76. doi: 10.1002/stem.1552.


Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-α activation in breast cancer cells in an IGF-independent manner.

Hermani A, Shukla A, Medunjanin S, Werner H, Mayer D.

Cell Signal. 2013 Jun;25(6):1395-402. doi: 10.1016/j.cellsig.2013.02.018. Epub 2013 Mar 14.


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