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Neutralizing antibodies can initiate genome release from human enterovirus 71.

Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2134-9. doi: 10.1073/pnas.1320624111.


Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody.

Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, Jiang W, Zhang L, Huang Z, Cong Y.

PLoS Pathog. 2016 Mar 3;12(3):e1005454. doi: 10.1371/journal.ppat.1005454.


The enterovirus 71 procapsid binds neutralizing antibodies and rescues virus infection in vitro.

Shingler KL, Cifuente JO, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

J Virol. 2015 Feb;89(3):1900-8. doi: 10.1128/JVI.03098-14.


Cryo-electron microscopy study of insect cell-expressed enterovirus 71 and coxsackievirus a16 virus-like particles provides a structural basis for vaccine development.

Gong M, Zhu H, Zhou J, Yang C, Feng J, Huang X, Ji G, Xu H, Zhu P.

J Virol. 2014 Jun;88(11):6444-52. doi: 10.1128/JVI.00200-14.


A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody.

Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S.

J Virol. 2013 Nov;87(21):11363-70. doi: 10.1128/JVI.01926-13.


Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps.

Ku Z, Ye X, Huang X, Cai Y, Liu Q, Li Y, Su Z, Huang Z.

PLoS One. 2013;8(2):e57601. doi: 10.1371/journal.pone.0057601.


The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoEM study of picornavirus uncoating.

Shingler KL, Yoder JL, Carnegie MS, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

PLoS Pathog. 2013 Mar;9(3):e1003240. doi: 10.1371/journal.ppat.1003240. Erratum in: PLoS Pathog. 2013 Sep;9(9). doi: 10.1371/annotation/e92d19e0-996a-4bfa-afdd-20dce770ed75.


Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.

Chen Y, Li C, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen PJ, Zhang J, Xia N.

Vaccine. 2013 Jan 2;31(2):425-30. doi: 10.1016/j.vaccine.2012.10.032.


Generation and characterization of a protective mouse monoclonal antibody against human enterovirus 71.

Deng YQ, Ma J, Xu LJ, Li YX, Zhao H, Han JF, Tao J, Li XF, Zhu SY, Qin ED, Qin CF.

Appl Microbiol Biotechnol. 2015 Sep;99(18):7663-71. doi: 10.1007/s00253-015-6652-8.


High-yield production of recombinant virus-like particles of enterovirus 71 in Pichia pastoris and their protective efficacy against oral viral challenge in mice.

Zhang C, Ku Z, Liu Q, Wang X, Chen T, Ye X, Li D, Jin X, Huang Z.

Vaccine. 2015 May 11;33(20):2335-41. doi: 10.1016/j.vaccine.2015.03.034.


Monoclonal neutralizing antibodies against EV71 screened from mice immunized with yeast-produced virus-like particles.

Lin T, Xianyu L, Lyu S.

Virol Sin. 2015 Jun;30(3):208-13. doi: 10.1007/s12250-015-3573-8.


Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.

Tsou YL, Lin YW, Shao HY, Yu SL, Wu SR, Lin HY, Liu CC, Huang C, Chong P, Chow YH.

PLoS Negl Trop Dis. 2015 Apr 9;9(4):e0003692. doi: 10.1371/journal.pntd.0003692.


A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein.

Kiener TK, Jia Q, Meng T, Chow VT, Kwang J.

PLoS Negl Trop Dis. 2014 May 29;8(5):e2895. doi: 10.1371/journal.pntd.0002895.


Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge.

Chung YC, Ho MS, Wu JC, Chen WJ, Huang JH, Chou ST, Hu YC.

Vaccine. 2008 Mar 28;26(15):1855-62. doi: 10.1016/j.vaccine.2008.01.058.


Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice.

Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C.

Hum Vaccin Immunother. 2014;10(10):2885-95. doi: 10.4161/hv.29823.


Protection against enterovirus 71 with neutralizing epitope incorporation within adenovirus type 3 hexon.

Tian X, Su X, Li X, Li H, Li T, Zhou Z, Zhong T, Zhou R.

PLoS One. 2012;7(7):e41381. doi: 10.1371/journal.pone.0041381. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/2da932d4-8654-45c8-bf83-7b3b09dbc146.


Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in mice.

Zhao D, Sun B, Jiang H, Sun S, Kong FT, Ma Y, Jiang L, Bai L, Chen X, Yang P, Liu C, Xu Y, Su W, Kong W, Xu F, Jiang C.

J Appl Microbiol. 2015 Oct;119(4):1196-205. doi: 10.1111/jam.12922.


Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles.

Lin YL, Yu CI, Hu YC, Tsai TJ, Kuo YC, Chi WK, Lin AN, Chiang BL.

Vaccine. 2012 Feb 8;30(7):1305-12. doi: 10.1016/j.vaccine.2011.12.081.


Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop.

Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T, Xia N.

Theranostics. 2014 Feb 18;4(5):498-513. doi: 10.7150/thno.7457.

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