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TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.

Frescas D, de Lange T.

Mol Cell Biol. 2014 Apr;34(7):1349-62. doi: 10.1128/MCB.01052-13. Epub 2014 Jan 27.


Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.

Frescas D, de Lange T.

J Biol Chem. 2014 Aug 29;289(35):24180-7. doi: 10.1074/jbc.M114.592592. Epub 2014 Jul 23.


Telomere protection by TPP1/POT1 requires tethering to TIN2.

Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T.

Mol Cell. 2011 Nov 18;44(4):647-59. doi: 10.1016/j.molcel.2011.08.043.


In vivo stoichiometry of shelterin components.

Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T.

J Biol Chem. 2010 Jan 8;285(2):1457-67. doi: 10.1074/jbc.M109.038026. Epub 2009 Oct 28.


Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas.

Butler KS, Hines WC, Heaphy CM, Griffith JK.

Cancer Med. 2012 Oct;1(2):165-75. doi: 10.1002/cam4.14. Epub 2012 Jul 24.


TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T.

J Biol Chem. 2004 Nov 5;279(45):47264-71. Epub 2004 Aug 16.


A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.

O'Connor MS, Safari A, Xin H, Liu D, Songyang Z.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11874-9. Epub 2006 Jul 31.


Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.

Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J.

J Cell Biol. 2008 May 5;181(3):447-60. doi: 10.1083/jcb.200710028. Epub 2008 Apr 28.


Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD.

Nat Struct Mol Biol. 2007 Aug;14(8):754-61. Epub 2007 Jul 15. Erratum in: Nat Struct Mol Biol. 2009 May;16(5):572.


Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing "stemness"-related markers.

Kim H, Yoo JE, Cho JY, Oh BK, Yoon YS, Han HS, Lee HS, Jang JJ, Jeong SH, Kim JW, Park YN.

J Hepatol. 2013 Oct;59(4):746-52. doi: 10.1016/j.jhep.2013.05.011. Epub 2013 May 14.


TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

Zimmermann M, Kibe T, Kabir S, de Lange T.

Genes Dev. 2014 Nov 15;28(22):2477-91. doi: 10.1101/gad.251611.114. Epub 2014 Oct 24.


TIN2 mediates functions of TRF2 at human telomeres.

Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J.

J Biol Chem. 2004 Oct 15;279(42):43799-804. Epub 2004 Aug 3.


Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.

Hu C, Rai R, Huang C, Broton C, Long J, Xu Y, Xue J, Lei M, Chang S, Chen Y.

Cell Res. 2017 Dec;27(12):1485-1502. doi: 10.1038/cr.2017.144. Epub 2017 Nov 21.


Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides.

Kalathiya U, Padariya M, Baginski M.

Eur Biophys J. 2017 Mar;46(2):171-187. doi: 10.1007/s00249-016-1157-7. Epub 2016 Jul 22.


Telomere maintenance through spatial control of telomeric proteins.

Chen LY, Liu D, Songyang Z.

Mol Cell Biol. 2007 Aug;27(16):5898-909. Epub 2007 Jun 11.


A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.

Houghtaling BR, Cuttonaro L, Chang W, Smith S.

Curr Biol. 2004 Sep 21;14(18):1621-31.


TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.

Xin H, Liu D, Wan M, Safari A, Kim H, Sun W, O'Connor MS, Songyang Z.

Nature. 2007 Feb 1;445(7127):559-62. Epub 2007 Jan 21.


Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

Liu D, O'Connor MS, Qin J, Songyang Z.

J Biol Chem. 2004 Dec 3;279(49):51338-42. Epub 2004 Sep 20.


Changes in the expression of telomere maintenance genes might play a role in the pathogenesis of systemic lupus erythematosus.

Zhou JG, Qing YF, Yang QB, Xie WG, Zhao MC.

Lupus. 2011 Jul;20(8):820-8. doi: 10.1177/0961203310397964.


Characterization of the DNA binding specificity of Shelterin complexes.

Choi KH, Farrell AS, Lakamp AS, Ouellette MM.

Nucleic Acids Res. 2011 Nov;39(21):9206-23. doi: 10.1093/nar/gkr665. Epub 2011 Aug 18.

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