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Items: 1 to 20 of 171

1.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP.

PLoS One. 2014 Jan 21;9(1):e85883. doi: 10.1371/journal.pone.0085883. eCollection 2014.

2.

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.

McCormack MP, Shields BJ, Jackson JT, Nasa C, Shi W, Slater NJ, Tremblay CS, Rabbitts TH, Curtis DJ.

Blood. 2013 Sep 19;122(12):2093-103. doi: 10.1182/blood-2012-09-458570. Epub 2013 Aug 7.

3.

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

Shields BJ, Alserihi R, Nasa C, Bogue C, Alexander WS, McCormack MP.

Leukemia. 2015 Apr;29(4):927-38. doi: 10.1038/leu.2014.292. Epub 2014 Oct 6.

PMID:
25283843
4.

The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.

McCormack MP, Young LF, Vasudevan S, de Graaf CA, Codrington R, Rabbitts TH, Jane SM, Curtis DJ.

Science. 2010 Feb 12;327(5967):879-83. doi: 10.1126/science.1182378. Epub 2010 Jan 21.

5.

Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.

Goodings C, Tripathi R, Cleveland SM, Elliott N, Guo Y, Shyr Y, Davé UP.

Leuk Res. 2015 Jan;39(1):100-9. doi: 10.1016/j.leukres.2014.11.016. Epub 2014 Nov 29.

6.

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.

Oram SH, Thoms JA, Pridans C, Janes ME, Kinston SJ, Anand S, Landry JR, Lock RB, Jayaraman PS, Huntly BJ, Pimanda JE, Göttgens B.

Oncogene. 2010 Oct 28;29(43):5796-808. doi: 10.1038/onc.2010.320. Epub 2010 Aug 2.

PMID:
20676125
7.

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE.

Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2.

8.

Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells.

Deleuze V, El-Hajj R, Chalhoub E, Dohet C, Pinet V, Couttet P, Mathieu D.

PLoS One. 2012;7(7):e40484. doi: 10.1371/journal.pone.0040484. Epub 2012 Jul 6.

9.

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.

Draheim KM, Hermance N, Yang Y, Arous E, Calvo J, Kelliher MA.

Oncogene. 2011 Mar 10;30(10):1252-60. doi: 10.1038/onc.2010.495. Epub 2010 Nov 8.

10.

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T.

PLoS Genet. 2014 Dec 18;10(12):e1004768. doi: 10.1371/journal.pgen.1004768. eCollection 2014 Dec.

11.

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.

Layer JH, Alford CE, McDonald WH, Davé UP.

Mol Cell Biol. 2015 Nov 23;36(3):488-506. doi: 10.1128/MCB.00901-15.

12.

Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements.

Homminga I, Vuerhard MJ, Langerak AW, Buijs-Gladdines J, Pieters R, Meijerink JP.

Haematologica. 2012 Feb;97(2):258-61. doi: 10.3324/haematol.2011.051722. Epub 2011 Nov 4.

13.

Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia.

Sun W, Yang S, Shen W, Li H, Gao Y, Zhu TH.

Eur J Haematol. 2010 Dec;85(6):508-19. doi: 10.1111/j.1600-0609.2010.01519.x.

PMID:
20731704
14.

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster JC, Kelliher MA.

Blood. 2011 Aug 11;118(6):1579-90. doi: 10.1182/blood-2010-08-300343. Epub 2011 Jun 13.

15.

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.

Cleveland SM, Smith S, Tripathi R, Mathias EM, Goodings C, Elliott N, Peng D, El-Rifai W, Yi D, Chen X, Li L, Mullighan C, Downing JR, Love P, Davé UP.

Stem Cells. 2013 May;31(5):882-94. doi: 10.1002/stem.1345.

16.

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.

Calero-Nieto FJ, Joshi A, Bonadies N, Kinston S, Chan WI, Gudgin E, Pridans C, Landry JR, Kikuchi J, Huntly BJ, Gottgens B.

Oncogene. 2013 Nov 28;32(48):5471-80. doi: 10.1038/onc.2013.175. Epub 2013 May 27.

17.

Transcriptional deregulation of oncogenic myocyte enhancer factor 2C in T-cell acute lymphoblastic leukemia.

Nagel S, Venturini L, Meyer C, Kaufmann M, Scherr M, Drexler HG, Macleod RA.

Leuk Lymphoma. 2011 Feb;52(2):290-7. doi: 10.3109/10428194.2010.537003. Epub 2011 Jan 24.

PMID:
21261500
18.
19.

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).

Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K.

Blood. 2010 Aug 12;116(6):962-70. doi: 10.1182/blood-2009-09-244673. Epub 2010 Jun 2.

20.

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.

El Omari K, Hoosdally SJ, Tuladhar K, Karia D, Vyas P, Patient R, Porcher C, Mancini EJ.

Blood. 2011 Feb 17;117(7):2146-56. doi: 10.1182/blood-2010-07-293357. Epub 2010 Nov 12.

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