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The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats.

Zhang HH, Zhang XQ, Xue QS, Yan-Luo, Huang JL, Zhang S, Shao HJ, Lu H, Wang WY, Yu BW.

PLoS One. 2014 Jan 21;9(1):e85536. doi: 10.1371/journal.pone.0085536. eCollection 2014.


Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats.

Zhang HH, Zhang XQ, Wang WY, Xue QS, Lu H, Huang JL, Gui T, Yu BW.

PLoS One. 2012;7(10):e46666. doi: 10.1371/journal.pone.0046666. Epub 2012 Oct 2.


Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia.

Fang-Hu, Zhang HH, Yang BX, Huang JL, Shun JL, Kong FJ, Peng-Xu, Chen ZG, Lu JM.

Brain Res. 2015 Sep 4;1619:166-75. doi: 10.1016/j.brainres.2015.01.056. Epub 2015 Mar 26.


Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.

Lin YT, Ro LS, Wang HL, Chen JC.

J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.


ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity.

Zhang X, Zhang H, Shao H, Xue Q, Yu B.

PLoS One. 2014 Jan 31;9(1):e87788. doi: 10.1371/journal.pone.0087788. eCollection 2014.


Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation.

Geng SJ, Liao FF, Dang WH, Ding X, Liu XD, Cai J, Han JS, Wan Y, Xing GG.

Exp Neurol. 2010 Apr;222(2):256-66. doi: 10.1016/j.expneurol.2010.01.003. Epub 2010 Jan 14.


Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats.

Zhang W, Liu LY, Xu TL.

Neuroscience. 2008 Mar 18;152(2):502-10. doi: 10.1016/j.neuroscience.2007.12.037. Epub 2008 Jan 8.


Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.

Yang YR, He Y, Zhang Y, Li Y, Li Y, Han Y, Zhu H, Wang Y.

Pain. 2007 Jan;127(1-2):109-20. Epub 2006 Sep 25.


Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat.

Matayoshi S, Jiang N, Katafuchi T, Koga K, Furue H, Yasaka T, Nakatsuka T, Zhou XF, Kawasaki Y, Tanaka N, Yoshimura M.

J Physiol. 2005 Dec 1;569(Pt 2):685-95. Epub 2005 Oct 6.


BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.

Jiang JM, Zhou CF, Gao SL, Tian Y, Wang CY, Wang L, Gu HF, Tang XQ.

PLoS One. 2015 Mar 6;10(3):e0119478. doi: 10.1371/journal.pone.0119478. eCollection 2015.


Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning.

Rattiner LM, Davis M, French CT, Ressler KJ.

J Neurosci. 2004 May 19;24(20):4796-806.


Transcutaneous electrical nerve stimulation attenuates CFA-induced hyperalgesia and inhibits spinal ERK1/2-COX-2 pathway activation in rats.

Fang JF, Liang Y, Du JY, Fang JQ.

BMC Complement Altern Med. 2013 Jun 15;13:134. doi: 10.1186/1472-6882-13-134.


Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation.

Huie JR, Garraway SM, Baumbauer KM, Hoy KC Jr, Beas BS, Montgomery KS, Bizon JL, Grau JW.

Neuroscience. 2012 Jan 3;200:74-90. doi: 10.1016/j.neuroscience.2011.10.028. Epub 2011 Oct 25.


4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and TrkB-related signaling in anterior cingulate cortex in chronic pain with depression-like behavior.

Ishikawa K, Yasuda S, Fukuhara K, Iwanaga Y, Ida Y, Ishikawa J, Yamagata H, Ono M, Kakeda T, Ishikawa T.

Neuroreport. 2014 Mar 5;25(4):226-32. doi: 10.1097/WNR.0000000000000072.


Epigenetic upregulation of Cdk5 in the dorsal horn contributes to neuropathic pain in rats.

Li K, Zhao GQ, Li LY, Wu GZ, Cui SS.

Neuroreport. 2014 Oct 1;25(14):1116-21. doi: 10.1097/WNR.0000000000000237.

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