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Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy.

Guo XL, Hu F, Zhang SS, Zhao QD, Zong C, Ye F, Guo SW, Zhang JW, Li R, Wu MC, Wei LX.

Cancer Lett. 2014 May 1;346(2):278-84. doi: 10.1016/j.canlet.2014.01.011. Epub 2014 Jan 22.


5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.

Seo K, Ki SH, Park EY, Shin SM.

Arch Pharm Res. 2017 Feb;40(2):231-239. doi: 10.1007/s12272-016-0878-6. Epub 2016 Dec 27.


Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.

Li X, Yu J, Brock MV, Tao Q, Herman JG, Liang P, Guo M.

Oncotarget. 2015 May 10;6(13):11547-60.


Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma.

Guo XL, Li D, Sun K, Wang J, Liu Y, Song JR, Zhao QD, Zhang SS, Deng WJ, Zhao X, Wu MC, Wei LX.

J Mol Med (Berl). 2013 Apr;91(4):473-83. doi: 10.1007/s00109-012-0966-0. Epub 2012 Oct 10.


Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound.

Hu Z, Lv G, Li Y, Li E, Li H, Zhou Q, Yang B, Cao W.

J Exp Clin Cancer Res. 2016 Apr 22;35:71. doi: 10.1186/s13046-016-0349-4.


Inhibition of Orai1-mediated Ca2+ entry enhances chemosensitivity of HepG2 hepatocarcinoma cells to 5-fluorouracil.

Tang BD, Xia X, Lv XF, Yu BX, Yuan JN, Mai XY, Shang JY, Zhou JG, Liang SJ, Pang RP.

J Cell Mol Med. 2017 May;21(5):904-915. doi: 10.1111/jcmm.13029. Epub 2016 Nov 23.


Oxymatrine synergistically enhances the inhibitory effect of 5-fluorouracil on hepatocellular carcinoma in vitro and in vivo.

Liu Y, Bi T, Dai W, Wang G, Qian L, Gao Q, Shen G.

Tumour Biol. 2016 Jun;37(6):7589-97. doi: 10.1007/s13277-015-4642-1. Epub 2015 Dec 18.


Prospective impact of 5-FU in the induction of endoplasmic reticulum stress, modulation of GRP78 expression and autophagy in Sk-Hep1 cells.

Yadunandam AK, Yoon JS, Seong YA, Oh CW, Kim GD.

Int J Oncol. 2012 Sep;41(3):1036-42. doi: 10.3892/ijo.2012.1506. Epub 2012 Jun 6.


Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway.

Jiao J, Hong S, Zhang J, Ma L, Sun Y, Zhang D, Shen B, Zhu C.

Cancer Lett. 2012 Jul 1;320(1):96-103. doi: 10.1016/j.canlet.2012.01.035. Epub 2012 Feb 4.


Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.

Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, Wu MC, Wei LX.

Cancer Lett. 2012 Jul 28;320(2):171-9. doi: 10.1016/j.canlet.2012.03.002. Epub 2012 Mar 8.


Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy.

Hu F, Guo XL, Zhang SS, Zhao QD, Li R, Xu Q, Wei LX.

Oncol Lett. 2017 Aug;14(2):1959-1966. doi: 10.3892/ol.2017.6449. Epub 2017 Jun 21.


Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells.

Yang L, Wu D, Luo K, Wu S, Wu P.

Cancer Lett. 2009 Apr 18;276(2):180-8. doi: 10.1016/j.canlet.2008.11.015. Epub 2008 Dec 20.


5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma.

Hu XY, Liang JY, Guo XJ, Liu L, Guo YB.

Clin Exp Pharmacol Physiol. 2015 Feb;42(2):146-53. doi: 10.1111/1440-1681.12333.


JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy.

Sui X, Kong N, Wang X, Fang Y, Hu X, Xu Y, Chen W, Wang K, Li D, Jin W, Lou F, Zheng Y, Hu H, Gong L, Zhou X, Pan H, Han W.

Sci Rep. 2014 Apr 15;4:4694. doi: 10.1038/srep04694.


Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway.

Zou X, Liang J, Sun J, Hu X, Lei L, Wu D, Liu L.

J Pharmacol Sci. 2016 Aug;131(4):233-40. doi: 10.1016/j.jphs.2016.04.017. Epub 2016 Apr 22.


Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma.

Lim SC, Choi JE, Kang HS, Han SI.

Int J Cancer. 2010 Apr 1;126(7):1582-95. doi: 10.1002/ijc.24853. Erratum in: Int J Cancer. 2010 Jul 15;127(2). doi: 10.1002/ijc.25347. Si, Han [corrected to Han, Song Iy].


Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.

Wang X, Bai H, Zhang X, Liu J, Cao P, Liao N, Zhang W, Wang Z, Hai C.

Carcinogenesis. 2013 Jun;34(6):1323-30. doi: 10.1093/carcin/bgt058. Epub 2013 Feb 12.


5-Fluorouracil nanoparticles inhibit hepatocellular carcinoma via activation of the p53 pathway in the orthotopic transplant mouse model.

Cheng M, He B, Wan T, Zhu W, Han J, Zha B, Chen H, Yang F, Li Q, Wang W, Xu H, Ye T.

PLoS One. 2012;7(10):e47115. doi: 10.1371/journal.pone.0047115. Epub 2012 Oct 15.


Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

Carlisi D, Vassallo B, Lauricella M, Emanuele S, D'Anneo A, Di Leonardo E, Di Fazio P, Vento R, Tesoriere G.

Int J Oncol. 2008 Jan;32(1):177-84.


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