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24461294,26549806,20651361,26787261,17376296,18281123,30689998,27539140,21877710,21446835,12883037,20349925,19703066,26134000,22729748,22740515,24297449,22687635,25753585,11839682,15389886,14965369,22261315,17159504,24051085,12591734,20799280,30475650,17341418,15893420,19277950,23456625,25947085,12124345,12796401,19699753,24161344,19673930,25573651,27193734,24812029,15489891,10918610,17934787,26585176,14688022,10485490,17506939,18023967,24300974,10537362,26781309,12631620,16225761,14709334,12851688,25776512,27726288,25864648,23454208,24691828,24395529,28004121,30064123,27444344,21611769,17699800,25355727,27748805,28495516,28597042,24612785,16715131,29524123,21864799,22362357,27489231,26362062,19700217,17371872,27444971,29734851,32286950,17475222,28933787,25345917,35456022,17057737,25083589,24865236,24361520,19468799,25027936,27106025,25351837,15642733,28444871,31226654,29607921,29599332,24399733,27806706,23045963,25880284,23092269,22791147,24727941,34709688,21601631,28777435,23649764,23325562,23811287,24695790,29036189,22189907,16572896,30871060,25345853,29133046,12740906,29723165,26768552,15880572,25403108,25363687,15917298,26716515,12818371,27793925,18338172,27843533,27748898,12149148,27145925,29602129,27748797,26033480,23965728,28494726,25225290,24547973,28838831,25841200,22174819,24647918,18466679,31226632,28425856,27231235,27561984,31648127,16024641,29426985,24411197,22425182,26592500,25144895,26300055,31376566,24162829,29468481,29486954,35341826,26314270,28126518,28144994,34902296,26342773,22043989,20854805,22617428,28574470,17209006,32241917,28506909,10644891,28734581,24282290,27138740,18973184,26096576,25390210,24492855,25847862,25312819,19523467,15777800,31554189,25978938,22037315,33118390,27671299,23675978,29453076,26310849,27035096,25815777,25599995,19414586,30293083,19058178,32115531,17409959,18414057,27233606,17410645,16307741,23065571,9149846,31286781,29921888,31827170,25687876,31597403,31830590,17591444,19168796,30013990,29061136,29101813,16079477,18162471,33985397,28395152,27043582,30791593,17237278,26065701,26251569,25173462,27164073,37057216,22003962,19561399,25467291,28131714,28901260,24692707,26434319,33603672,32683166,30196062,18254244,31165800,19147759,31416117,16953122,27268718,32835419,29150078,32580819,35408988,30973113,21328513,24447339,34299042,27431486,29381295,24904961,21762107,26861280,24836554,20196957,30622010,11269744,24639390,10953309,26221874,29271659,25301738,29305298,18078828,25506265,32456600,30470491,20211752,32673843,25338756,28427199,30914025,27484517,25964547,26238775,34907714,28651979,25442375,32429154,15865490,11930011,21760551,8822090,31422225,17600140,31994958,9600337,26758798,31833479,29382424,20478545,23745985,29259993,25600535,27536893,31902913,29571156,33381866,25776505,28104581,29558289,19047146,20071291,25752336,18355692,31147570,34199423,26898345,33622229,34712051,17548205,30508737,15244525,26504023,34728247,32476531,29098529,16322690,28532227,28534969,32616192,24942548,26244039,28408844,28595067,28006662,18451518,31353710,28728840,23627273,20673479,33496142,30848214,19710177,29254203,24800887,31807521,21880714,27273342,8806101,27901471,32935429,26751081,24973521,20031166,36432003,32139200,32616191,15122068,26900660,26986492,27358039,35156777,22381066,25986882,8688674,30731401,35477254,23981532,32890994,26332341,25780420,18673131,1818438,19795097,25128424,21868241,16989490,33212515,22870141,26593678,33172112,23481641,29069735,26552366,34187946,34761594,34775357,26937173,9559782,26546528,12175697,34923092,33829017,30012506,29298657,26548762,33723318,36558080,34292737,19958823,24268542,35628312,29498756,32290461,22274867,36337251,28501784,24180274,34823804,29268974,35604429,34294017,23011016,32679249,23697951,29200721,24332487,32893968,35328482,27150153,26398575,22846508,9038721,29531821,35932565,30620026,27759573,26279158,36260776,32785022,24847381,32372662,36157229,29371968,8138560,18359628,21812421,26814091,26059305,24734098,17253132,24828377,28789420,33447049,7780111,26722245,21376163,33305655,12817616,32079825,35605555,20953389,6533282,29435082,36410114,16156517,27017112,20118561,24759000,11471039,25780691,26177809,26911897,25364659,32433008,25520882,31941829,27023745,26446298,26411032,23589723,19663788,36102619,2823818,31223451,22456543,23404433,34546667,30652053,29695699,22993540,23397442,23533526,30863176,24660105,22807953,31894688,32942772,36672551,22328962,35047442,21643465,11107443,25635254,21031151,24753815,23170112,26047291,34795858,29177791,33260653,21660118,21572583,21103068,30250255,27681797,23543830,29536249,29567377,29731187,14662029,33706401,35585417,30035977[uid]

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Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells.

Song J, Ko HS, Sohn EJ, Kim B, Kim JH, Kim HJ, Kim C, Kim JE, Kim SH. Song J, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1188-91. doi: 10.1016/j.bmcl.2013.12.111. Epub 2014 Jan 3. Bioorg Med Chem Lett. 2014. PMID: 24461294

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells.

Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ. Tang ZH, et al. Oncotarget. 2015 Dec 22;6(41):43911-26. doi: 10.18632/oncotarget.6084. Oncotarget. 2015. PMID: 26549806 Free PMC article.

Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.

Wu SH, Hang LW, Yang JS, Chen HY, Lin HY, Chiang JH, Lu CC, Yang JL, Lai TY, Ko YC, Chung JG. Wu SH, et al. Anticancer Res. 2010 Jun;30(6):2125-33. Anticancer Res. 2010. PMID: 20651361

c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.

Joo H, Lee HJ, Shin EA, Kim H, Seo KH, Baek NI, Kim B, Kim SH. Joo H, et al. Phytother Res. 2016 Apr;30(4):596-603. doi: 10.1002/ptr.5563. Epub 2016 Jan 20. Phytother Res. 2016. PMID: 26787261

Antitumor activity of a novel bis-aziridinylnaphthoquinone (AZ4) mediating cell cycle arrest and apoptosis in non-small cell lung cancer cell line NCI-H460.

Shyu KG, Huang ST, Kuo HS, Cheng WP, Lin YL. Shyu KG, et al. Acta Pharmacol Sin. 2007 Apr;28(4):559-66. doi: 10.1111/j.1745-7254.2007.00508.x. Acta Pharmacol Sin. 2007. PMID: 17376296

A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.

Jin HO, Seo SK, Woo SH, Lee HC, Kim ES, Yoo DH, Lee SJ, An S, Choe TB, Kim JI, Hong SI, Rhee CH, Park IC. Jin HO, et al. Lung Cancer. 2008 Sep;61(3):317-27. doi: 10.1016/j.lungcan.2008.01.002. Epub 2008 Feb 20. Lung Cancer. 2008. PMID: 18281123

Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5.

Kim YH, Shin EA, Jung JH, Park JE, Koo J, Koo JI, Shim BS, Kim SH. Kim YH, et al. Eur J Pharmacol. 2019 Mar 15;847:91-96. doi: 10.1016/j.ejphar.2019.01.028. Epub 2019 Jan 25. Eur J Pharmacol. 2019. PMID: 30689998

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.

Kao SJ, Lee WJ, Chang JH, Chow JM, Chung CL, Hung WY, Chien MH. Kao SJ, et al. Environ Toxicol. 2017 Apr;32(4):1426-1438. doi: 10.1002/tox.22336. Epub 2016 Aug 19. Environ Toxicol. 2017. PMID: 27539140

A synthetic naringenin derivative, 5-hydroxy-7,4'-diacetyloxyflavanone-N-phenyl hydrazone (N101-43), induces apoptosis through up-regulation of Fas/FasL expression and inhibition of PI3K/Akt signaling pathways in non-small-cell lung cancer cells.

Bak Y, Kim H, Kang JW, Lee DH, Kim MS, Park YS, Kim JH, Jung KY, Lim Y, Hong J, Yoon DY. Bak Y, et al. J Agric Food Chem. 2011 Sep 28;59(18):10286-97. doi: 10.1021/jf2017594. Epub 2011 Sep 6. J Agric Food Chem. 2011. PMID: 21877710

Chan-Yu-Bao-Yuan-Tang induces apoptosis in NSCLC and SCLC cell lines via a mitochondria-mediated pathway.

Zhang Y, Zeng F, Liu X, Li Y, Zhou J, Huang Y, Wang Y, Zhou S, Zhu W, Shu E, Zhou G, Chen G. Zhang Y, et al. Xenobiotica. 2011 Jul;41(7):593-602. doi: 10.3109/00498254.2011.565818. Epub 2011 Mar 29. Xenobiotica. 2011. PMID: 21446835

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